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CHEMOKINE ADJUVANTS FOR BIOTHREAT PATHOGEN VACCINES

Award Number: U19AI056690
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2003
PERIOD OF PERFORMANCE END DATE: 01/31/2008

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CHEMOKINE ADJUVANTS FOR BIOTHREAT PATHOGEN VACCINES - DESCRIPTION (provided by applicant): There is an extreme need to develop safer and more efficacious modes of prophylactic and therapeutic vaccination. This need is particularly acute in the area of non-conventional pathogens, such as anthrax and smallpox, due to the ease of weaponizing these agents, and the inadequacy of current prevention and treatment regimens. The goal of this multi-project program proposal is to develop novel, first-in-class immune activating agents to be used as enhanced adjuvants for nonconventional pathogens. Specifically, we aim to exploit the unique power of the chemokine system (a primary regulator of the trafficking patterns of the body's immune cells) to target both the innate immune response and acquired immunity. This will be done by exploiting chemokine-based modalities recently characterized in our organization. Specifically, the following approaches will be employed: (i) The use of a newly discovered chemokine-derived peptide, designated SHAAGtide (or PDX-S), identified here as a high affinity ligand for the formyl peptide receptor-related molecule FPRL-1, to actively engage innate immune responses; (ii) Using a virally derived chemokine vMCK-2 (or PDX-K), a highly potent attractant of APC and DC in vivo, to enhance acquired immune responses; (iii) The creation of novel medicinal chemical ligands ('chemomimetics') for FPRL-1 and the PDX-K receptor to provide new adjuvant modalities with an expanded range of administration routes; (iv) The creation of in vivo targeting and vaccine delivery vehicles, and finally, (v) Comparative assessment of all such modalities in mouse and non-human primate models to determine which agent (PDX-S, PDX-K, chemomimetic, etc) and form (soluble protein, DNA, medicinal chemical, or viral) shall be advanced through preclinical and into clinical development. Thus we aim to create powerful 'superadjuvants' - with markedly enhanced qualities over currently used adjuvants -for use in protection against Category A-C pathogens.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2007 ( Subtotal = $3,124,002 )
2007	2007	CHEMOCENTRYX INC	1539 INDUSTRIAL ROAD	SAN CARLOS	CA	94070	SAN MATEO	USA	Allergy and Infectious Diseases Research	000	5	2/6/2007	NON-COMPETING CONTINUATION	$3,124,002
														Subtotal = $3,124,002

Issue Date FY: 2006 ( Subtotal = $3,157,823 )
2006	2006	CHEMOCENTRYX INC	1539 INDUSTRIAL ROAD	SAN CARLOS	CA	94070	SAN MATEO	USA	Allergy and Infectious Diseases Research	000	4	6/19/2006	NON-COMPETING CONTINUATION	$3,157,823
														Subtotal = $3,157,823

Issue Date FY: 2004 ( Subtotal = $3,088,117 )
2004	2004	CHEMOCENTRYX INC	1539 INDUSTRIAL ROAD	SAN CARLOS	CA	94070	SAN MATEO	USA	Allergy and Infectious Diseases Research	000	2	9/10/2004	NON-COMPETING CONTINUATION	$3,088,117
														Subtotal = $3,088,117

Issue Date FY: 2003 ( Subtotal = $1,273,008 )
2003	2003	CHEMOCENTRYX INC	1539 INDUSTRIAL ROAD	SAN CARLOS	CA	94070	SAN MATEO	USA	Allergy and Infectious Diseases Research	000	1	9/29/2003	NEW	$1,273,008
														Subtotal = $1,273,008

Grand Total All Awards = $10,642,950

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CHEMOKINE ADJUVANTS FOR BIOTHREAT PATHOGEN VACCINES

Award Number: U19AI056690

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2003

PERIOD OF PERFORMANCE END DATE: 01/31/2008

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