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Interactions of SARS-CoV-2 infection and genetic variation on the risk of cognitive decline and Alzheimer’s disease in Ancestral and Admixed Populations

Award Number: U19AG076581
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2023
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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Interactions of SARS-CoV-2 infection and genetic variation on the risk of cognitive decline and Alzheimer’s disease in Ancestral and Admixed Populations - The science proposed in this program takes advantage of the unique scientific opportunity created by the ongoing coronavirus pandemic, to study the interaction between a definable and time-limited risk-inducing environmental event (exposure to the virus) and genomic variation on the occurrence of cognitive decline and Alzheimer’s disease and related dementias (ADRD) in large cohorts of older adults from multi-ancestry cohorts in the USA and ancestral groups in Africa and South America. The investigators leading the program have extensive experience in directing international consortia and longitudinal cohorts, including the creation and follow up of an Amerindian cohort in the Andes region for longer than a decade. We have pilot ascertainment of cognitive impairment end-points in newly recruited older adults of Amerindian ancestry. This U19 will investigate the interactions between whole genome sequence genetic variations and COVID-19 infection and disease on the risk of cognitive decline and risk of ADRD in 4,300 individuals as part of newly recruited cohorts in Texas, New York, Washington State, Ibadan (Nigeria), and Jujuy (Argentina). Participant assessments will include neurological, cognitive, imaging and blood-based biomarker evaluations using harmonized protocols and at 3 time points: within a few months of infection and 18 and 36 months afterwards. We propose to answer this complex research question with 3 highly integrated Projects supported by equally integrated Administrative, Clinical, Neuroimaging and Data Management/Statistics Cores. All projects involve integrated multidisciplinary teams of investigators within a consortium of institutions including University of Texas Health San Antonio, University of Texas Rio Grande Valley, Washington University School of Medicine, Albert Einstein College of Medicine, University of Washington, University of Ibadan, the Ministry of Health of the Province of Jujuy (Argentina) and the FULTRA Foundation (Argentina). Resources and study expertise will be tightly coordinated across multiple sites and Cores, and integrated to the National Institute of Aging Alzheimer’s Disease Sequencing Project and National Alzheimer’s Coordinating Center which will help ensure optimal sharing of the acquire data and knowledge.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $5,797,392 )
2026	2026	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	002	4	9/4/2026	SUPPLEMENT FOR EXPANSION	$1,823,594
2026	2026	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	001	4	8/26/2026	NON-COMPETING CONTINUATION	$3,973,798
2026	2025	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	3	1/27/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $5,797,392

Issue Date FY: 2025 ( Subtotal = $5,770,673 )
2025	2025	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	003	3	9/2/2025	SUPPLEMENT FOR EXPANSION	$806,739
2025	2025	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	001	3	8/26/2025	NON-COMPETING CONTINUATION	$4,853,251
2025	2025	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	002	3	8/29/2025	SUPPLEMENT FOR EXPANSION	$110,683
2025	2024	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	2	2/14/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $5,770,673

Issue Date FY: 2024 ( Subtotal = $8,610,822 )
2024	2024	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	002	2	8/30/2024	NON-COMPETING CONTINUATION	$8,610,822
2024	2023	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	1	1/4/2024	NEW	$0
2024	2023	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	001	1	4/25/2024	NEW	$0
														Subtotal = $8,610,822

Issue Date FY: 2023 ( Subtotal = $8,725,158 )
2023	2023	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	001	1	8/17/2023	NEW	$0
2023	2023	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	1	8/15/2023	NEW	$8,725,158
														Subtotal = $8,725,158

Grand Total All Awards = $28,904,045

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Interactions of SARS-CoV-2 infection and genetic variation on the risk of cognitive decline and Alzheimer’s disease in Ancestral and Admixed Populations

Award Number: U19AG076581

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2023

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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