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Adult Changes in Thought (ACT) Research Program

Award Number: U19AG066567
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2021
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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Adult Changes in Thought (ACT) Research Program - The Adult Changes in Thought (ACT) U19 Program will expand, modernize, and improve ACT's prospective cohort study to achieve advances in scientific understanding of older adults in general and dementia and Alzheimer's disease in particular. ACT is set in a healthcare delivery system. The study team identifies incident cases of dementia and Alzheimer's disease and follows consenting participants to autopsy. The Program will transform the current ACT U01 to a U19, which envisions complex multi-component programs that will have a powerful influence on the field. The Program's overarching goal is to identify risk factors across the life course that provide potential intervention targets for preserving cognition and preventing Alzheimer's disease and related dementias (ADRD). The Overall Specific Aims are: Aim 1. Expand ACT cohort enrollment and modernize and improve follow-up with emphasis on increasing racial/ethnic diversity and deep phenotyping of life course risk factors, cognitive and physical functioning, and outcomes including neuroimaging and neuropathology based ADRD outcomes. The Cores will expand cohort enrollment from 2,000 to 3,000. The study will invest in six Cores: A, Administrative; B, Clinical; C, Life Course; D, Neuropathology; E, Neuroimaging; F, Data and Analysis. These Cores will work together to further enhance the value of ACT's resources, enabling the ACT study to continue to be the foundation for an extraordinary array of science. To date, ACT has achieved a completeness of follow-up index of 94.5% and has observed 56,140 person-years of follow-up. ACT has identified >1,300 incident dementia cases and >1,000 incident Alzheimer's cases. The study has completed >850 autopsies and will surpass 1,100 autopsies this cycle. Additionally, 1,077 ACT participants had one MRI scan, and 540 have had ≥2, with funding in place for hundreds more. Aim 2. Support key Projects studying the spectrum of healthy functioning to ADRD in older adults. The three Projects center around 24-hour cycle physical activity, sedentary behavior, and sleep patterns in old age (Project 1), the implications of cognitively defined Alzheimer's disease subgroups (Project 2), and mechanisms underlying neural protection and toxicity of strong anticholinergic drugs and antihypertensive drugs (Project 3). Aim 3. Expand and improve ACT's dissemination of exceptional resources to the research community guided by NIA's adopted FAIR (Findable, Accessible, Interoperable, and Reproducible) principles. ACT has proven to be an exceptional resource to the research community, providing data and specimens to research colleagues locally, across the country, and around the world, and provides mentorship to junior investigators. We will continue to enhance our data sharing capabilities in this U19 Program.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Aging Research	001	5	3/3/2026	NON-COMPETING CONTINUATION	$0
2026	2025	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Aging Research	000	5	1/28/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $12,403,176 )
2025	2025	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Aging Research	000	4	12/11/2024	SUPPLEMENT FOR EXPANSION	$773,720
2025	2025	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Aging Research	001	5	4/16/2025	NON-COMPETING CONTINUATION	$10,680,112
2025	2025	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Aging Research	002	5	8/21/2025	NON-COMPETING CONTINUATION	$949,344
														Subtotal = $12,403,176

Issue Date FY: 2024 ( Subtotal = $11,040,953 )
2024	2024	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Aging Research	001	4	8/17/2024	NON-COMPETING CONTINUATION	$0
2024	2024	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Aging Research	000	4	6/25/2024	NON-COMPETING CONTINUATION	$11,040,953
														Subtotal = $11,040,953

Issue Date FY: 2023 ( Subtotal = $11,060,502 )
2023	2023	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Aging Research	002	3	9/20/2023	NON-COMPETING CONTINUATION	$0
2023	2023	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Aging Research	001	3	6/27/2023	NON-COMPETING CONTINUATION	$11,060,502
2023	2022	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Aging Research	000	2	3/17/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $11,060,502

Issue Date FY: 2022 ( Subtotal = $10,767,047 )
2022	2022	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Aging Research	000	2	7/27/2022	NON-COMPETING CONTINUATION	$10,767,047
														Subtotal = $10,767,047

Issue Date FY: 2021 ( Subtotal = $11,720,668 )
2021	2021	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Aging Research	001	1	7/16/2021	NEW	$0
2021	2021	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Aging Research	000	1	5/13/2021	NEW	$11,720,668
														Subtotal = $11,720,668

Grand Total All Awards = $56,992,346

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Adult Changes in Thought (ACT) Research Program

Award Number: U19AG066567

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2021

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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