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Longevity Consortium

Award Number: U19AG023122
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2004
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Longevity Consortium - Overall Summary The processes contributing to human aging, age-related diseases (e.g., Alzheimer’s disease and related dementias; ADRD), and longevity are notoriously complex and multifactorial. This complexity makes it difficult to identify longevity-promoting (i.e. geroprotective) interventions and targets, clinically useful biomarkers, and predictive models that could enhance human health. One strategy to overcome this is to assess the findings of one study in the light of findings from studies with different designs or foci – i.e., integrate or ‘triangulate’ those findings – such as cell models, cross species studies and human association studies. Such integration could lead to further validation of individual findings and put into context any one or group of such findings. The LC will embark on an unprecedented level of integration by capitalizing on its legacy findings and 20+ year history, network of investigators, expanded data sharing capabilities, unique resources, and assay capabilities, and pursue 5 projects (P1-P5) taking different approaches. Each is designed to address a specific overarching objective of the RFA and contribute data and results for use in integrated analyses. In addition, an Integrated Analysis Core (IAC) and an Administrative Core (AC) will be developed to address further objectives in the RFA. The five projects are rooted in research efforts and discoveries in the last LC funding cycle: P1 will study diverse human populations to determine the contexts within which longevity-related factors exhibit associations; P2 will study genomically-mediated evolutionary processes contributing to longevity; P3 will study extreme longevity (EL) and its relationship to ADRD in diverse human populations; P4 will study aging rate indicators in response to candidate geroprotective drugs in mice; and P5 will explore novel cell systems and constructs derived from individuals with EL and other longevity related phenotypes. The IAC will seek to integrate results and data across these projects by developing appropriate infrastructure and analytical methods, as well as engaging in analyses with the research teams pursuing each project. The AC will oversee and track progress of the research as well as monitor financial and related activities. The LC will also work with the NIA-funded Data Management and Coordinating Center (DMCC) and its Exceptional Longevity Translational Resources (ELITE) internet data portal to enable broader access to LC data. Working groups will enhance specific activities, e.g., data sharing and training, and, importantly, a Pharmaceutical and Translational Advisory Panel (PTAP) will be established to enable discussions about the best way to follow up findings in drug development contexts. The LC will identify compelling and verified insights into human longevity based on the proposed studies and its expansive integrated approach and ultimately identify novel vetted candidate pre-clinical drug targets, geroprotective interventions, health biomarkers, and predictive models of longevity-related phenotypes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	TRANSLATIONAL GENOMICS RESEARCH INSTITUTE	445 N 5TH ST	PHOENIX	AZ	85004	MARICOPA	USA	Aging Research	000	16	11/7/2024	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $8,688,414 )
2024	2024	TRANSLATIONAL GENOMICS RESEARCH INSTITUTE	445 N 5TH ST	PHOENIX	AZ	85004	MARICOPA	USA	Aging Research	002	16	9/20/2024	COMPETING CONTINUATION	$8,688,414
2024	2022	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	15	9/20/2024	NON-COMPETING CONTINUATION	$0
2024	2022	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	15	8/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $8,688,414

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	15	5/12/2023	NON-COMPETING CONTINUATION	$0
2023	2022	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	15	3/15/2023	NON-COMPETING CONTINUATION	$0
2023	2022	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	002	15	7/20/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $6,913,922 )
2022	2022	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	004	15	9/15/2022	NON-COMPETING CONTINUATION	$0
2022	2022	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	15	8/19/2022	NON-COMPETING CONTINUATION	$6,913,922
2022	2021	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	002	14	9/12/2022	NON-COMPETING CONTINUATION	$0
2022	2021	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	003	14	9/14/2022	NON-COMPETING CONTINUATION	$0
2022	2021	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	14	11/17/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $6,913,922

Issue Date FY: 2021 ( Subtotal = $8,845,192 )
2021	2021	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	004	14	7/9/2021	NON-COMPETING CONTINUATION	$8,845,192
2021	2020	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	003	13	10/23/2020	NON-COMPETING CONTINUATION	$0
2021	2015	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	002	10	10/3/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2015	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	10	10/3/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2015	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	10	10/1/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $8,845,192

Issue Date FY: 2020 ( Subtotal = $8,603,133 )
2020	2020	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	004	13	7/6/2020	NON-COMPETING CONTINUATION	$8,142,428
2020	2020	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	006	13	9/2/2020	SUPPLEMENT FOR EXPANSION	$187,500
2020	2020	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	005	13	8/19/2020	SUPPLEMENT FOR EXPANSION	$270,410
2020	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	003	11	2/7/2020	COMPETING CONTINUATION	$3,200
2020	2016	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	002	10	2/7/2020	SUPPLEMENT FOR EXPANSION	-$405
2020	2016	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	10	11/15/2019	SUPPLEMENT FOR EXPANSION	$405
2020	2015	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	10	11/15/2019	SUPPLEMENT FOR EXPANSION	-$405
														Subtotal = $8,603,133

Issue Date FY: 2019 ( Subtotal = $8,306,569 )
2019	2019	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	006	12	8/9/2019	NON-COMPETING CONTINUATION	$7,976,787
2019	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	005	11	8/5/2019	COMPETING CONTINUATION	$329,782
2019	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	003	11	7/11/2019	COMPETING CONTINUATION	-$7,854,905
2019	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	002	11	4/23/2019	COMPETING CONTINUATION	$0
2019	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	11	3/19/2019	COMPETING CONTINUATION	$0
2019	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	11	4/18/2019	COMPETING CONTINUATION	$0
2019	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	004	11	7/17/2019	COMPETING CONTINUATION	$7,854,905
														Subtotal = $8,306,569

Issue Date FY: 2018 ( Subtotal = $7,852,109 )
2018	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	003	11	9/19/2018	COMPETING CONTINUATION	$7,854,905
2018	2016	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	10	5/1/2018	SUPPLEMENT FOR EXPANSION	$2,794
2018	2016	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	002	10	5/2/2018	SUPPLEMENT FOR EXPANSION	-$2,796
2018	2015	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	10	5/1/2018	SUPPLEMENT FOR EXPANSION	-$2,794
														Subtotal = $7,852,109

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	SUTTER BAY HOSPITALS	633 FOLSOM STREET 5TH FLOOR	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	10	9/22/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $51,456 )
2016	2016	CALIFORNIA PACIFIC MEDICAL CENTER	2340 CLAY STREET, 5TH FL	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Aging Research	000	10	8/18/2016	SUPPLEMENT FOR EXPANSION	$51,456
														Subtotal = $51,456

Issue Date FY: 2015 ( Subtotal = $1,815,237 )
2015	2015	CALIFORNIA PACIFIC MEDICAL CENTER	2340 CLAY STREET, 5TH FL	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Aging Research	001	10	9/4/2015	SUPPLEMENT FOR EXPANSION	$70,816
2015	2015	CALIFORNIA PACIFIC MEDICAL CENTER	2340 CLAY STREET, 5TH FL	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Aging Research	000	10	8/5/2015	NON-COMPETING CONTINUATION	$1,744,421
														Subtotal = $1,815,237

Grand Total All Awards = $72,117,521

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Longevity Consortium

Award Number: U19AG023122

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2004

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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