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Longevity Consortium

Award Number: U19AG023122
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ABSTRACT: THE LONGEVITY CONSORTIUM (LC). Multiple studies of model organisms and humans have suggested that genetic variants, proteins, metabolites, as well as other biomolecules and molecular- physiologic processes, could play roles in mediating longevity, healthspan, and age-related disease in humans. Unfortunately, the direct relevance of many of these factors to human longevity, healthspan and age-related disease is uncertain, as is the amenability of these factors to pharmacological modulation. Therefore, well-integrated and sophisticated research strategies are needed to determine the degree to which various factors both influence human longevity and are amenable to pharmacological manipulation. The Longevity Consortium (LC) has a history of precedent-setting studies seeking to identify factors that influence human longevity and healthspan and has recently redefined its goals and research strategies to achieve an appropriate level of integration and sophistication to elucidate additional factors affecting longevity, as well as their interactions and translatability into targets for pharmacotherapeutic manipulation. To enable appropriate integration in human longevity research, the LC will exploit a multiple investigator structure with 5 interlinked research projects and 3 integrative cores. These projects and cores will include: A cross-species project focusing on cellular and organismal phenotypes led by Richard Miller (referred to as the Miller-Mice/Cell project hereafter); a metabolomics project led by Oliver Fiehn (Fiehn-Metabolomics); a Centenarians project co-led by Thomas Perls and Paola Sebastiani (Perls- Centenarian); a proteomics project led by Eric Orwoll (Orwoll-Proteomics) and a disease context project led by Nicholas Schork (Schork-Disease Context). The cores include a Systems Biology core led by Nathan Price (Price-Systems), a Chemoinformatics core led by Thomas Girke (Girke-Chemoinformatics), and an administrative core with an overall administrative component led by Steve Cummings (Cummings-Admin) and a scientific integration component led by Nicholas Schork. Drs. Cummings and Schork, as Multiple PIs, will share responsibility for the overall leadership of the LC effort. The proposed LC will complement, and partner with, an NIA-funded U24 project (U24AG051129) involving many LC investigators to construct a website for data dissemination. 1


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	15	5/12/2023	NON-COMPETING CONTINUATION	$0
2023	2022	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	002	15	7/20/2023	NON-COMPETING CONTINUATION	$0
2023	2022	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	15	3/15/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $6,913,922 )
2022	2022	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	004	15	9/15/2022	NON-COMPETING CONTINUATION	$0
2022	2022	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	15	8/19/2022	NON-COMPETING CONTINUATION	$6,913,922
2022	2021	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	003	14	9/14/2022	NON-COMPETING CONTINUATION	$0
2022	2021	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	14	11/17/2021	NON-COMPETING CONTINUATION	$0
2022	2021	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	002	14	9/12/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $6,913,922

Issue Date FY: 2021 ( Subtotal = $8,845,192 )
2021	2021	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	004	14	7/9/2021	NON-COMPETING CONTINUATION	$8,845,192
2021	2020	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	003	13	10/23/2020	NON-COMPETING CONTINUATION	$0
2021	2015	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	002	10	10/3/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2015	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	10	10/3/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2015	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	10	10/1/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $8,845,192

Issue Date FY: 2020 ( Subtotal = $8,603,133 )
2020	2020	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	005	13	8/19/2020	SUPPLEMENT FOR EXPANSION	$270,410
2020	2020	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	004	13	7/6/2020	NON-COMPETING CONTINUATION	$8,142,428
2020	2020	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	006	13	9/2/2020	SUPPLEMENT FOR EXPANSION	$187,500
2020	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	003	11	2/7/2020	COMPETING CONTINUATION	$3,200
2020	2016	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	002	10	2/7/2020	SUPPLEMENT FOR EXPANSION	-$405
2020	2016	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	10	11/15/2019	SUPPLEMENT FOR EXPANSION	$405
2020	2015	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	10	11/15/2019	SUPPLEMENT FOR EXPANSION	-$405
														Subtotal = $8,603,133

Issue Date FY: 2019 ( Subtotal = $8,306,569 )
2019	2019	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	006	12	8/9/2019	NON-COMPETING CONTINUATION	$7,976,787
2019	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	005	11	8/5/2019	COMPETING CONTINUATION	$329,782
2019	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	003	11	7/11/2019	COMPETING CONTINUATION	-$7,854,905
2019	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	11	4/18/2019	COMPETING CONTINUATION	$0
2019	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	002	11	4/23/2019	COMPETING CONTINUATION	$0
2019	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	004	11	7/17/2019	COMPETING CONTINUATION	$7,854,905
2019	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	11	3/19/2019	COMPETING CONTINUATION	$0
														Subtotal = $8,306,569

Issue Date FY: 2018 ( Subtotal = $7,852,109 )
2018	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	003	11	9/19/2018	COMPETING CONTINUATION	$7,854,905
2018	2016	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	10	5/1/2018	SUPPLEMENT FOR EXPANSION	$2,794
2018	2016	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	002	10	5/2/2018	SUPPLEMENT FOR EXPANSION	-$2,796
2018	2015	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	10	5/1/2018	SUPPLEMENT FOR EXPANSION	-$2,794
														Subtotal = $7,852,109

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	SUTTER BAY HOSPITALS	633 FOLSOM STREET 5TH FLOOR	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	10	9/22/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $51,456 )
2016	2016	CALIFORNIA PACIFIC MEDICAL CENTER	2340 CLAY STREET, 5TH FL	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Aging Research	000	10	8/18/2016	SUPPLEMENT FOR EXPANSION	$51,456
														Subtotal = $51,456

Issue Date FY: 2015 ( Subtotal = $1,815,237 )
2015	2015	CALIFORNIA PACIFIC MEDICAL CENTER	2340 CLAY STREET, 5TH FL	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Aging Research	001	10	9/4/2015	SUPPLEMENT FOR EXPANSION	$70,816
2015	2015	CALIFORNIA PACIFIC MEDICAL CENTER	2340 CLAY STREET, 5TH FL	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Aging Research	000	10	8/5/2015	NON-COMPETING CONTINUATION	$1,744,421
														Subtotal = $1,815,237

Issue Date FY: 2014 ( Subtotal = $1,945,810 )
2014	2014	CALIFORNIA PACIFIC MEDICAL CENTER	2340 CLAY STREET, 5TH FL	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Aging Research	000	9	7/24/2014	NON-COMPETING CONTINUATION	$1,843,588
2014	2014	CALIFORNIA PACIFIC MEDICAL CENTER	2340 CLAY STREET, 5TH FL	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Aging Research	001	9	9/15/2014	SUPPLEMENT FOR EXPANSION	$102,222
														Subtotal = $1,945,810

Issue Date FY: 2013 ( Subtotal = $1,813,765 )
2013	2013	CALIFORNIA PACIFIC MEDICAL CENTER	2340 CLAY STREET, 5TH FL	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Aging Research	000	8	8/21/2013	NON-COMPETING CONTINUATION	$1,813,765
														Subtotal = $1,813,765

Issue Date FY: 2012 ( Subtotal = $1,939,679 ) (Continued on the next page)
Grand Total All Awards = $63,429,107

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Longevity Consortium

Award Number: U19AG023122

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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