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Development of an Integrated Microbiome-Resistome Surveillance Framework for Antimicrobial Resistance and Surgical Site Infection in Veterinary Orthopedic Surgery

Award Number: U18FD008933
ORGANIZATION: FOOD AND DRUG ADMINISTRATION
OPDIV: FDA
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: KDA (KNOWLEDGE/DEVELOPMENT/APPLICATION)
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Development of an Integrated Microbiome-Resistome Surveillance Framework for Antimicrobial Resistance and Surgical Site Infection in Veterinary Orthopedic Surgery - Project Summary Rationale: Surgical site infections (SSIs) and antimicrobial prophylaxis failure/resistance remain critical challenges in veterinary surgery, yet the origins of these pathogens are often unclear. This project investigates the hypothesis that preoperative microbial communities and resistome profiles serve as internal reservoirs for the pathogens and resistance determinants that cause postoperative SSIs and prophylaxis failure in animals. Aim 1: An integrated microbiome-genomic framework will be utilized to determine if bacterial strains identified in clinical SSI cultures are present in the host’s preoperative microbiome. This strain-level comparison will enable the development of standardized antimicrobial resistance (AMR) surveillance workflows and prevention strategies to reduce the rate of SSIs. Aim 2: The project will evaluate the association between the preoperative resistome and the development of prophylaxis-resistant infections. By identifying specific resistance gene reservoirs, we can determine their direct relationship with prophylaxis failure, providing data crucial for antimicrobial stewardship. Aim 3: Comparative genomic analysis will characterize S. pseudintermedius strains isolated from SSI wounds versus apparently healthy surgical wounds. Specific focus will be on antimicrobial resistance genes, virulence factors, and genomic variations (SNPs/indels) to distinguish pathogenic from commensal strains, which will inform new preventive and treatment strategies. Significance: This research aligns with the Center for Veterinary Medicine’s (CVM) goal to enhance the monitoring of animal pathogens and promote antimicrobial stewardship. By shifting the focus toward the patient’s own microbiome as a source of infection, this study provides a new framework for diagnostic laboratories to predict and prevent SSIs. Methodology: Our approach leverages veterinary clinical surgery, bacteriological techniques, next generation sequencing (NGS) and advanced bioinformatics. Outcome: The expected results include a validated genomic workflow for strain tracking and actionable data for clinicians to refine antimicrobial prophylaxis. Ultimately, this will improve patient outcomes and reduce the use of antimicrobials in veterinary medicine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $134,469 )
2026	2026	KANSAS STATE UNIVERSITY	1601 VATTIER STREET	MANHATTAN	KS	66506	RILEY	USA	Food and Drug Administration Research	000	1	9/23/2026	NEW	$134,469
														Subtotal = $134,469

Grand Total All Awards = $134,469

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Development of an Integrated Microbiome-Resistome Surveillance Framework for Antimicrobial Resistance and Surgical Site Infection in Veterinary Orthopedic Surgery

Award Number: U18FD008933

ORGANIZATION: FOOD AND DRUG ADMINISTRATION

OPDIV: FDA

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: KDA (KNOWLEDGE/DEVELOPMENT/APPLICATION)

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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