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Development of analytical methods for detecting microcystins in fish tissue

Award Number: U18FD008339
ORGANIZATION: FOOD AND DRUG ADMINISTRATION
OPDIV: FDA
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: KDA (KNOWLEDGE/DEVELOPMENT/APPLICATION)
PERIOD OF PERFORMANCE START DATE: 09/01/2024
PERIOD OF PERFORMANCE END DATE: 04/30/2025

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Development of analytical methods for detecting microcystins in fish tissue - Project Summary/Abstract Harmful algal blooms (HABs) consisting of cyanobacterial species have been increasing in waterways in the United States and elsewhere due to the impacts of pollution and climate change. Cyanobacteria produce a number of cyanotoxins, the most common of which are microcystin-LR and related microcystins, which are potent hepatotoxins. Microcystins are known to bioaccumulate in aquatic organisms, some of which are part of the human food chain. While commercial ELISA kits are available to screen water samples for microcystins and Liquid Chromatography/Mass Spectrometry (LC/MS) methods have been developed to quantitate microcystin in water, there has been limited research on detecting or quantitating microcystins and their metabolites in biological matrices. Some studies have attempted to use commercial ELISA kits developed to screen water samples to screen samples of fish meat, but these methods have not been thoroughly validated. We will develop and validate a robust quantitative LC/MS method to quantitate microcystin in fish, other animal tissues, to be used for veterinary diagnostic investigation and food safety assurance. This method will be used to validate the rapid ELISA-based screening method that has been developed Todd Miller at the University of Wisconsin, Milwaukee.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $46,249 )
2026	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Food and Drug Administration Research	000	2	12/17/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$46,249
2026	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Food and Drug Administration Research	001	2	1/7/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2026	2024	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Food and Drug Administration Research	002	1	1/13/2026	NEW	$0
														Subtotal = $46,249

Issue Date FY: 2025 ( Subtotal = -$46,249 )
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Food and Drug Administration Research	002	2	9/23/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$46,249
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Food and Drug Administration Research	001	2	9/22/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$46,249
2025	2024	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Food and Drug Administration Research	000	1	9/18/2025	NEW	-$46,249
														Subtotal = -$46,249

Issue Date FY: 2024 ( Subtotal = $51,974 )
2024	2024	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Food and Drug Administration Research	000	1	7/31/2024	NEW	$51,974
														Subtotal = $51,974

Grand Total All Awards = $51,974

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Development of analytical methods for detecting microcystins in fish tissue

Award Number: U18FD008339

ORGANIZATION: FOOD AND DRUG ADMINISTRATION

OPDIV: FDA

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: KDA (KNOWLEDGE/DEVELOPMENT/APPLICATION)

PERIOD OF PERFORMANCE START DATE: 09/01/2024

PERIOD OF PERFORMANCE END DATE: 04/30/2025

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