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Collaborative Study on the Genetics of Alcoholism (COGA).

Award Number: U10AA008401
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/29/1989
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Collaborative Study on the Genetics of Alcoholism (COGA). - The Collaborative Study on the Genetics of Alcoholism (COGA) is a tightly integrated and interdisciplinary project, whose overarching goals are to understand the contributions and interactions of genetic, neurobiological, and social-environmental influences on the course of AUD, remission, and recurrence over the lifespan. COGA is a study of large, diverse families, many densely affected by AUD; family members have been characterized in clinical, behavioral, neurophysiological, neuropsychological, and social-environmental domains, yielding a rich phenotypic dataset paired with a large repository of biospecimens and genomewide data in 12,145 family members, as well as molecular and cellular genomic data that provide functional insights. With recent reports of increased heavy alcohol use and AUD in those ages 40 and older, it is critical that we gain a deeper understanding of the risk and resilience factors throughout the course of AUD during this period of the lifespan, and alcohol-related consequences (e.g., mental and physical health problems, cognitive decline, early mortality). COGA builds on the key strengths of our research achievements over the past 35 years and will now focus on adding new multi-domain data collection in those aged 40 and older to expand the longitudinal data available in our sample as they enter later life. The breadth and depth of longitudinal assessments in COGA families allow a fully panoramic view of the course of AUD, remission and recurrence and its consequences, enabling genomic analyses to be conducted within lifetime accumulation of risk and protective influences. In response to RFA-AA-24-003, we propose three inter-related and inter-dependent projects (Lifespan, Brain Function, Genomics) supported by three essential cores (NIAAA-COGA Sharing Repository (NCSR), Data Management and Coordination (DMC), and Administrative). Consistent with the RFA and in keeping with COGA’s research agenda, the overarching specific aims for the next five years are: Aim 1: Advance our understanding of the longitudinal course of alcohol use and AUD, and its adverse outcomes by studying genetic and social-environmental factors across the lifespan. Aim 2: Examine how the course of AUD and remission shapes brain functioning across the lifespan, and its consequences in later life, and the role of genetic and social-environmental factors in AUD-related brain function. Aim 3: Integrate genetic, genomic and functional studies to characterize AUD trajectories and related mental, behavioral and brain health outcomes across the lifespan. COGA’s multi-pronged approach, long history of productive collaboration among investigators, and commitment to data sharing, will allow us to propel the alcohol research field towards actionable findings that can be positioned to translate science to population health and clinical care. This advancement of science is only possible within a U10 mechanism that supports effective collaboration, integration and synergy among research modalities (lifespan, brain function, genomics) to address the serious public health challenge of AUD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	000	36	11/26/2024	COMPETING CONTINUATION	$0
2025	2024	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	003	36	5/7/2025	COMPETING CONTINUATION	$221,927
2025	2024	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	001	36	4/17/2025	COMPETING CONTINUATION	$0
2025	2023	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	002	35	5/7/2025	NON-COMPETING CONTINUATION	-$221,927
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $5,905,584 )
2024	2024	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	001	36	9/20/2024	COMPETING CONTINUATION	$5,905,584
2024	2023	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	000	35	9/19/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $5,905,584

Issue Date FY: 2023 ( Subtotal = $7,500,000 )
2023	2023	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	000	35	8/29/2023	NON-COMPETING CONTINUATION	$7,500,000
														Subtotal = $7,500,000

Issue Date FY: 2022 ( Subtotal = $7,499,733 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	001	34	8/25/2022	NON-COMPETING CONTINUATION	$7,500,000
2022	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	000	30	6/29/2022	NON-COMPETING CONTINUATION	-$267
														Subtotal = $7,499,733

Issue Date FY: 2021 ( Subtotal = $7,648,112 )
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	002	33	8/24/2021	NON-COMPETING CONTINUATION	$7,500,000
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	003	33	8/28/2021	SUPPLEMENT FOR EXPANSION	$148,112
2021	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	001	31	2/9/2021	COMPETING CONTINUATION	$34,306
2021	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	000	30	2/9/2021	NON-COMPETING CONTINUATION	-$34,306
														Subtotal = $7,648,112

Issue Date FY: 2020 ( Subtotal = $7,233,358 )
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	006	32	8/19/2020	NON-COMPETING CONTINUATION	$176,343
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	005	32	8/14/2020	NON-COMPETING CONTINUATION	$7,057,015
2020	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	004	31	3/28/2020	COMPETING CONTINUATION	$3,587
2020	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	002	31	1/21/2020	COMPETING CONTINUATION	$443,468
2020	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	000	30	1/21/2020	NON-COMPETING CONTINUATION	-$49,735
2020	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	003	30	3/28/2020	NON-COMPETING CONTINUATION	-$3,587
2020	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	001	30	1/21/2020	SUPPLEMENT FOR EXPANSION	-$393,733
														Subtotal = $7,233,358

Issue Date FY: 2019 ( Subtotal = $7,500,000 )
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	001	31	9/3/2019	COMPETING CONTINUATION	$7,500,000
2019	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	000	30	3/13/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $7,500,000

Issue Date FY: 2018 ( Subtotal = $7,737,301 )
2018	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	001	30	9/17/2018	SUPPLEMENT FOR EXPANSION	$393,733
2018	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	000	30	8/6/2018	NON-COMPETING CONTINUATION	$7,343,568
														Subtotal = $7,737,301

Issue Date FY: 2017 ( Subtotal = $7,391,119 )
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Alcohol Research Programs	000	29	8/15/2017	NON-COMPETING CONTINUATION	$7,391,119
														Subtotal = $7,391,119

Issue Date FY: 2016 ( Subtotal = $7,478,259 )
2016	2016	UNIVERSITY HOSPITAL OF DOWNSTATE MEDICAL CENTER	450 CLARKSON AVENUE	NEW YORK-KINGS	NY	11203		USA	Alcohol Research Programs	002	28	8/26/2016	SUPPLEMENT FOR EXPANSION	$52,083
2016	2016	UNIVERSITY HOSPITAL OF DOWNSTATE MEDICAL CENTER	450 CLARKSON AVENUE	NEW YORK-KINGS	NY	11203		USA	Alcohol Research Programs	001	28	8/12/2016	NON-COMPETING CONTINUATION	$7,428,803
2016	2015	UNIVERSITY HOSPITAL OF DOWNSTATE MEDICAL CENTER	450 CLARKSON AVENUE	NEW YORK-KINGS	NY	11203		USA	Alcohol Research Programs	000	27	10/27/2015	SUPPLEMENT FOR EXPANSION	-$2,627
														Subtotal = $7,478,259

Issue Date FY: 2015 ( Subtotal = $7,250,489 )
2015	2015	UNIVERSITY HOSPITAL OF DOWNSTATE MEDICAL CENTER	450 CLARKSON AVENUE	NEW YORK-KINGS	NY	11203		USA	Alcohol Research Programs	001	27	8/20/2015	SUPPLEMENT FOR EXPANSION	$70,791
2015	2015	UNIVERSITY HOSPITAL OF DOWNSTATE MEDICAL CENTER	450 CLARKSON AVENUE	NEW YORK-KINGS	NY	11203		USA	Alcohol Research Programs	000	27	8/10/2015	NON-COMPETING CONTINUATION	$7,179,698
														Subtotal = $7,250,489

Issue Date FY: 2014 ( Subtotal = $6,750,000 )
2014	2014	UNIVERSITY HOSPITAL OF DOWNSTATE MEDICAL CENTER	450 CLARKSON AVENUE	NEW YORK-KINGS	NY	11203		USA	Alcohol Research Programs	000	26	8/29/2014	COMPETING CONTINUATION	$6,750,000
														Subtotal = $6,750,000

Issue Date FY: 2013 ( Subtotal = $6,297,596 )
2013	2013	UNIVERSITY HOSPITAL OF DOWNSTATE MEDICAL CENTER	450 CLARKSON AVENUE	NEW YORK-KINGS	NY	11203		USA	Alcohol Research Programs	000	25	8/12/2013	NON-COMPETING CONTINUATION	$6,297,596
														Subtotal = $6,297,596

Issue Date FY: 2012 ( Subtotal = $6,789,384 )
2012	2012	UNIVERSITY HOSPITAL OF DOWNSTATE MEDICAL CENTER	450 CLARKSON AVENUE	NEW YORK-KINGS	NY	11203		USA	Alcohol Research Programs	000	24	8/27/2012	NON-COMPETING CONTINUATION	$6,789,384
														Subtotal = $6,789,384

Issue Date FY: 2011 ( Subtotal = $6,806,304 )
2011	2011	UNIVERSITY HOSPITAL OF DOWNSTATE MEDICAL CENTER	450 CLARKSON AVENUE	NEW YORK-KINGS	NY	11203		USA	Alcohol Research Programs	000	23	8/15/2011	NON-COMPETING CONTINUATION	$6,806,304
														Subtotal = $6,806,304

Issue Date FY: 2010 ( Subtotal = $6,890,683 ) (Continued on the next page)
Grand Total All Awards = $140,504,038

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Collaborative Study on the Genetics of Alcoholism (COGA).

Award Number: U10AA008401

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/29/1989

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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