Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Monitoring of disease-induced skin VOC patterns from handheld and wearable chemical sensors

Award Number: U01TR004083
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/22/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2027

Group Awards By:

View Award Description

Monitoring of disease-induced skin VOC patterns from handheld and wearable chemical sensors - Project Summary/Abstract: This project will bring two skin VOC sensors (hand-held, wearable) into clinical use to improve rapid diagnostics for a range of health conditions. Skin VOC monitoring is a new concept with potential to transform healthcare. Our hypothesis is that miniature skin VOC analysis devices can be coupled with vital sign sensors to measure disease signatures in real-time faster than a traditional differential diagnosis. The proposal has four goals: (1) adapt our current volatile organic compound (VOC) detector into a hand-held format for gas phase skin-emitted metabolites, coupled to non-invasive vital sign sensors and artificial intelligence machine learning (AI/ML) algorithms; (2) deploy our hand-held skin VOC system on 20 diseases over 5 years; (3) adapt our current wearable vital monitoring system to include our skin VOC detector, and use this to monitor persistent asthma patients for disease flares; (4) prepare for our project and devices to move through commercial manufacturing, standardization and FDA regulatory approval. To meet these goals, we plan the following: in Aim #1, we adapt our miniature VOC detection device for skin measurements, and couple it with 7 commercial-off-the-shelf vital sign sensors (skin temperature, pulse rate, respiration rate, heart rate, oxygen saturation, galvanic skin response, skin humidity). Our miniature differential mobility spectrometry detector is coupled with a chip-based preconcentrator and miniature gas chromatograph column for chemical separation and detection. Individual components have already been developed. Under direction of MPI Prof. Davis, UC Davis Chair of Mechanical and Aerospace Engineering, a team of engineers will adapt these pieces together into a hand-held unit for skin VOC sampling/analysis. Co-I Prof. Chuah will guide development of AI/ML capability for automated data processing and interpretation from the integrated VOC and vital sign data streams. In Aim #2, we will use this hand-held system at two different clinical sites to develop AI/ML signatures for 20 different diseases compared to appropriately selected controls. The UC Davis site led by MPI Nicholas Kenyon will focus on: 2 skin diseases (eczema, psoriasis), 7 lung diseases (asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, pulmonary hypertension, pulmonary embolism, sarcoidosis, sickle cell disease with respiratory symptoms), 3 joint and connective tissue diseases (rheumatoid arthritis, psoriatic arthritis, osteoarthritis), 4 mental health diseases (attention deficit hyperactivity disorder, autism, schizophrenia, Fragile X premutation with mental health symptoms). The Children’s Hospital of Philadelphia site lead by Co-I Audrey John will focus on: 4 pediatric fevers (urinary tract infection, enterovirus infection, respiratory syncytial virus infection, influenza infection). In Aim #3, our team will combine our current wearable vital sign sensors with our miniature VOC sensor, and identifying a novel profile for persistent asthma disease flares from both data streams. Aim #4 will develop a manufacturing, commercialization, standardization and FDA regulatory pathway for our devices/tests. These efforts are in conjunction UC Davis start-up company SensIT Ventures.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,299,417 )
2026	2026	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	National Center for Advancing Translational Sciences	001	5	9/2/2026	NON-COMPETING CONTINUATION	$0
2026	2026	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	National Center for Advancing Translational Sciences	000	5	6/12/2026	NON-COMPETING CONTINUATION	$1,299,417
														Subtotal = $1,299,417

Issue Date FY: 2025 ( Subtotal = $1,298,160 )
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	National Center for Advancing Translational Sciences	000	4	7/4/2025	NON-COMPETING CONTINUATION	$1,298,160
														Subtotal = $1,298,160

Issue Date FY: 2024 ( Subtotal = $1,320,252 )
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	National Center for Advancing Translational Sciences	002	3	5/30/2024	NON-COMPETING CONTINUATION	$1,320,252
2024	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	National Center for Advancing Translational Sciences	000	2	2/26/2024	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	National Center for Advancing Translational Sciences	001	2	5/3/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,320,252

Issue Date FY: 2023 ( Subtotal = $1,002,189 )
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	National Center for Advancing Translational Sciences	000	2	6/2/2023	NON-COMPETING CONTINUATION	$1,002,189
														Subtotal = $1,002,189

Issue Date FY: 2022 ( Subtotal = $988,302 )
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	National Center for Advancing Translational Sciences	001	1	9/24/2022	NEW	$0
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	National Center for Advancing Translational Sciences	000	1	6/22/2022	NEW	$988,302
														Subtotal = $988,302

Grand Total All Awards = $5,908,320

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Monitoring of disease-induced skin VOC patterns from handheld and wearable chemical sensors

Award Number: U01TR004083

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/22/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer