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CRITICAL: Collaborative Resource for Intensive care Translational science, Informatics, Comprehensive Analytics, and Learning

Award Number: U01TR003528
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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CRITICAL: Collaborative Resource for Intensive care Translational science, Informatics, Comprehensive Analytics, and Learning - Translational research in Artificial Intelligence (AI) has been hindered by the lack of shared data resources with sufficient depth, breadth and representative of the greater population of the nation. There are very limited EHR datasets freely available to the general research community especially the AI research community through credential-based access. MIMIC dataset is from a single institution that is not representative of the greater population of the nation. The eICU dataset is limited in data comprehensiveness (e.g., number of kinds of lab tests ~1/5 of MIMIC), data span (1 year, 2014-2015), and data variety (e.g., no free text clinical notes) etc. Thus MIMIC and eICU respectively have advantages and disadvantages of data depth and data breadth. The vision of this proposal is to leverage multiple CTSAs with patients representative of the greater population of the nation to develop and evaluate a multi-site de-identified ICU dataset, to facilitate accelerate translational research in AI and deep learning approaches to understand, track, and predict the pathophysiological state of patients. In this project, a group of nationwide CTSA sites will work together to build a new, larger, multi-site dataset that is downloadable by researchers with credential-based access. This project will combine the respective advantages of MIMIC (data depth) and eICU (data breadth). The created dataset will include more geographic regions, larger quantities of time-series data, including pre-, during- and post- ICU patient information. This will incorporate not only more patients, but also capture regional population differences and practice variations that could have clinical impact. Aim 1 will develop and provide credentialed access to a multi-site dataset consisting of de-identified discrete outpatient, inpatient, and ICU data for critically ill at respective CTSAs. Aim 2 will create federated access dataset from and develop novel federated learning methods on the part of the multi-site ICU data consisting of unstructured clinical notes or structured data for select group of patients at higher risks of re-identification (e.g., rare disease patients). Aim 3 will develop novel memory-network based meta-learning AI algorithms and use the multi-site dataset to answer concrete and long-standing clinical problems in critical care. Aim 4 will innovatively leverage the library network to develop and disseminate open resources for the research community and develop best practice guidelines for other CTSAs to join the effort. In particular, we aim to support and cultivate the growth of next generation medical AI workforce for research and practice. We aim to establish a large cross-CTSA collaborative data sharing for critical care by leveraging the existing CTSA collaborative networks. With the patients from the above CTSAs representative of the greater population of the nation, we will be able to support fair and generalizable algorithms for advanced patient monitoring and decision support. The proposed project will provide best practice guidance to and set up exemplary examples for nationwide CTSAs. It will also support the cultivation of next generation medical AI researchers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	National Center for Advancing Translational Sciences	000	4	7/3/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	National Center for Advancing Translational Sciences	000	4	9/5/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,202,911 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	National Center for Advancing Translational Sciences	001	4	9/11/2024	NON-COMPETING CONTINUATION	$1,202,911
2024	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	National Center for Advancing Translational Sciences	000	3	1/16/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,202,911

Issue Date FY: 2023 ( Subtotal = $1,203,166 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	National Center for Advancing Translational Sciences	000	3	8/10/2023	NON-COMPETING CONTINUATION	$1,203,166
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	National Center for Advancing Translational Sciences	001	3	8/24/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,203,166

Issue Date FY: 2022 ( Subtotal = $1,202,957 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	National Center for Advancing Translational Sciences	000	2	7/28/2022	NON-COMPETING CONTINUATION	$1,202,957
														Subtotal = $1,202,957

Issue Date FY: 2021 ( Subtotal = $1,255,336 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	National Center for Advancing Translational Sciences	000	1	8/3/2021	NEW	$1,255,336
														Subtotal = $1,255,336

Grand Total All Awards = $4,864,370

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CRITICAL: Collaborative Resource for Intensive care Translational science, Informatics, Comprehensive Analytics, and Learning

Award Number: U01TR003528

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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