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Undiagnosed Diseases Network Metabolomics Core

Award Number: U01TR001395
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2015
PERIOD OF PERFORMANCE END DATE: 04/30/2019

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Undiagnosed Diseases Network Metabolomics Core - DESCRIPTION (provided by applicant): A state of the art metabolomics core will be a vital part of the Undiagnosed Diseases Network (UDN). However, in order for the UDN to realize it's the full potential it is essential that the metabolomics core doesn't simply function as a high tec referral lab. We propose the formation of a partnership that will combine the state of the art analytical capabilities of the Pacific Northwest National Laboratory (PNNL), with clinical, genetic and bioinformatics expertise from Oregon Health & Science University (OHSU), to create a metabolomics core that functions as a fully integrated component of the network. The integration of this combined expertise will facilitate the linkage of novel metabolites or patterns of metabolites identified by the metabolomics core to the underlying metabolic and genetic derangements, as well as clinical signs and symptoms, and to translate this knowledge into specific clues regarding the genetic etiology of the patient's disorder. The major goal of this metabolomics core is to provide metabolomics assays and computational resources that will address the enormous challenges in developing a modern approach to the use of metabolomics in the diagnosis of disease. To achieve these objectives, we will interact with the UDN Centers to provide guidance on all aspects of metabolomics experimental design, sample collection and storage, sample analysis, and data processing and analysis. We will perform comprehensive, quantitative untargeted and targeted measurements to identify changes in molecular profiles that are associated with rare and undiagnosed diseases, while providing structural determination of novel metabolites associated with undiagnosed diseases. Working closely with the UDN Centers, including the treating physicians, we will integrate metabolomics and genomics data with patient clinical phenotypes to both aid diagnosis and provide mechanistic insight for rare and undiagnosed diseases. This work is significant because it applies state-of-the- art and advanced metabolomics, lipidomics, and glycomics measurements in the study of rare and undiagnosed diseases. This work is innovative because it combines the collective expertise in mass spectrometry and omics measurements of the PNNL team with the expertise in inherited metabolic disease and deep semantic phenotyping of the OHSU team and applies it to the challenge of diagnosis of disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2017	BATTELLE MEMORIAL INSTITUTE	902 BATTELLE BLVD	RICHLAND	WA	99354	BENTON	USA	Trans-NIH Research Support	000	3	5/5/2025	NON-COMPETING CONTINUATION	-$1,249
2025	2017	BATTELLE MEMORIAL INSTITUTE	902 BATTELLE BLVD	RICHLAND	WA	99354	BENTON	USA	Trans-NIH Research Support	001	3	5/5/2025	NON-COMPETING CONTINUATION	$1,249
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = -$1,318 )
2022	2018	BATTELLE MEMORIAL INSTITUTE	902 BATTELLE BLVD	RICHLAND	WA	99354	BENTON	USA	Trans-NIH Research Support	001	3	6/29/2022	SUPPLEMENT FOR EXPANSION	-$1,318
2022	2017	BATTELLE MEMORIAL INSTITUTE	902 BATTELLE BLVD	RICHLAND	WA	99354	BENTON	USA	Trans-NIH Research Support	000	3	6/29/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = -$1,318

Issue Date FY: 2021 ( Subtotal = $1,249 )
2021	2018	BATTELLE MEMORIAL INSTITUTE	900 BATTELLE BLVD	RICHLAND	WA	99352	BENTON	USA	Trans-NIH Research Support	000	3	5/17/2021	SUPPLEMENT FOR EXPANSION	$1,249
														Subtotal = $1,249

Issue Date FY: 2019 ( Subtotal = -$1,249 )
2019	2018	BATTELLE MEMORIAL INSTITUTE	900 BATTELLE BLVD	RICHLAND	WA	99352	BENTON	USA	Trans-NIH Research Support	002	3	8/5/2019	SUPPLEMENT FOR EXPANSION	-$1,249
2019	2018	BATTELLE MEMORIAL INSTITUTE	900 BATTELLE BLVD	RICHLAND	WA	99352	BENTON	USA	Trans-NIH Research Support	001	3	10/23/2018	SUPPLEMENT FOR EXPANSION	$0
2019	2017	BATTELLE MEMORIAL INSTITUTE	900 BATTELLE BLVD	RICHLAND	WA	99352	BENTON	USA	Trans-NIH Research Support	000	3	10/23/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = -$1,249

Issue Date FY: 2018 ( Subtotal = $170,181 )
2018	2018	BATTELLE MEMORIAL INSTITUTE	900 BATTELLE BLVD	RICHLAND	WA	99352	BENTON	USA	Trans-NIH Research Support	001	3	7/25/2018	SUPPLEMENT FOR EXPANSION	$170,181
2018	2017	BATTELLE MEMORIAL INSTITUTE	900 BATTELLE BLVD	RICHLAND	WA	99352	BENTON	USA	Trans-NIH Research Support	000	3	7/25/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $170,181

Issue Date FY: 2017 ( Subtotal = $477,354 )
2017	2017	BATTELLE MEMORIAL INSTITUTE	900 BATTELLE BLVD	RICHLAND	WA	99352	BENTON	USA	Trans-NIH Research Support	000	3	8/7/2017	NON-COMPETING CONTINUATION	$477,354
														Subtotal = $477,354

Issue Date FY: 2016 ( Subtotal = $737,370 )
2016	2016	PACIFIC NORTHWEST LAB, DIV OF BATTELLE MEMORIAL INST	POST OFFICE BOX 999	RICHLAND	WA	99352	BENTON	USA	Trans-NIH Research Support	000	2	7/22/2016	NON-COMPETING CONTINUATION	$487,370
2016	2016	PACIFIC NORTHWEST LAB, DIV OF BATTELLE MEMORIAL INST	POST OFFICE BOX 999	RICHLAND	WA	99352	BENTON	USA	Research Infrastructure Programs	001	2	9/22/2016	SUPPLEMENT FOR EXPANSION	$250,000
														Subtotal = $737,370

Issue Date FY: 2015 ( Subtotal = $882,455 )
2015	2015	PACIFIC NORTHWEST LAB, DIV OF BATTELLE MEMORIAL INST	POST OFFICE BOX 999	RICHLAND	WA	99352	BENTON	USA	Trans-NIH Research Support	000	1	9/20/2015	NEW	$882,455
														Subtotal = $882,455

Grand Total All Awards = $2,266,042

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Undiagnosed Diseases Network Metabolomics Core

Award Number: U01TR001395

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2015

PERIOD OF PERFORMANCE END DATE: 04/30/2019

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