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Evaluation of TransLife Center: A Locally-Developed Combination Prevention Intervention for Transgender Women at High Risk of HIV Infection

Award Number: U01PS005140
ORGANIZATION: NATIONAL CENTER FOR PREVENTION SERVICES
OPDIV: CDC
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Combination interventions to reduce disparities in HIV infection for transgender women (TW) who have sex with men are sorely needed, as this population is one of the highest risk and most underserved groups in the United States. The goal of this proposed research project is to evaluate a locally developed and potentially effective intervention, the TransLife Center (TLC), which provides combination (i.e., biomedical, behavioral, social/structural) HIV prevention services to adult TW at high risk for HIV infection, in a culturally specific and highly accessible affirming environment. The TLC intervention directly addresses the structural barriers to health promotion among TW through a coordinated screening and service model, including direct access to services most needed and requested by TW: employment, housing, legal, and health services, following a social determinants of health conceptual model. To date there are no evidence-based HIV prevention interventions (EBIs) for TW listed in the CDC compendium of EBIs. The proposed study will address this gap through collaboration between Chicago House and Social Service Agency (Chicago House), a long-standing HIV/AIDS service provider and HIV prevention researchers who have been actively engaged in the development of HIV prevention interventions for TW. Our experience suggests that Chicago House's TLC intervention is feasible and acceptable to the target population, with over 200 HIV-uninfected TW participating in services over the past three years and evidence suggesting potential efficacy of the intervention for both sexual risk reduction and health promotion. We propose to test the TLC intervention in a single arm trial among 100 HIV-uninfected and sexually active TW, ages 18 and older, and evaluate intervention effectiveness over a 12-month period with visits at 6-month intervals (baseline, 6-months, 12-months). All participants will receive standard-of-care HIV/STI prevention and testing services, assessment and linkage to pre-exposure prophylaxis (PrEP), as indicated. We will evaluate the TLC intervention via the following aims: AIM 1) To determine the pre-post efficacy of the TLC intervention on the primary outcome: number of condomless anal sex acts without protection by PrEP. 1a) To assess the dose response relationship between intervention exposure as well as exposure to specific components (i.e., employment, housing, legal, and health) on reductions in the primary outcome. 1b) To assess mediation of intervention effects on protective processes (gender affirmation, collective self-esteem, social support) theorized to increase with intervention exposure; AIM 2) To examine intervention implementation experiences through semi-structured interviews with 20 TLC participants and 10 Chicago House staff members. AIM 3) Exploratory Aims: 3a) To describe the trajectory of PrEP indication, uptake, retention and adherence in the community-based sample over a 12-month follow-up period and evaluate the impact of the TLC intervention on the PrEP continuum of care. 3b) To explore whether reductions in HIV risk are associated with epidemiologically-linked moderators including age and race/ethnicity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2019	CHICAGO HOUSE AND SOCIAL SERVICE AGENCY	2229 S Michigan Ave	Chicago	IL	60616	COOK	USA	HIV Demonstration, Research, Public and Professional Education Projects	02	4	11/1/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2023	2018	CHICAGO HOUSE AND SOCIAL SERVICE AGENCY	2229 S Michigan Ave	Chicago	IL	60616	COOK	USA	HIV Demonstration, Research, Public and Professional Education Projects	02	4	11/1/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2023	2017	CHICAGO HOUSE AND SOCIAL SERVICE AGENCY	2229 S Michigan Ave	Chicago	IL	60616	COOK	USA	HIV Demonstration, Research, Public and Professional Education Projects	02	4	11/1/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2023	2016	CHICAGO HOUSE AND SOCIAL SERVICE AGENCY	2229 S Michigan Ave	Chicago	IL	60616	COOK	USA	HIV Demonstration, Research, Public and Professional Education Projects	02	4	11/1/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	CHICAGO HOUSE AND SOCIAL SERVICE AGENCY	1925 N CLYBOURN AVE STE 401	CHICAGO	IL	60614	COOK	USA	HIV Demonstration, Research, Public and Professional Education Projects	01	4	8/3/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $400,000 )
2019	2019	CHICAGO HOUSE AND SOCIAL SERVICE AGENCY	1925 N CLYBOURN AVE STE 401	CHICAGO	IL	60614	COOK	USA	HIV Demonstration, Research, Public and Professional Education Projects	00	4	6/17/2019	NON-COMPETING CONTINUATION	$400,000
														Subtotal = $400,000

Issue Date FY: 2018 ( Subtotal = $600,000 )
2018	2018	CHICAGO HOUSE AND SOCIAL SERVICE AGENCY	1925 N CLYBOURN AVE STE 401	CHICAGO	IL	60614	COOK	USA	HIV Demonstration, Research, Public and Professional Education Projects	00	3	7/27/2018	NON-COMPETING CONTINUATION	$600,000
2018	2017	CHICAGO HOUSE AND SOCIAL SERVICE AGENCY	1925 N CLYBOURN AVE STE 401	CHICAGO	IL	60614	COOK	USA	HIV Demonstration, Research, Public and Professional Education Projects	000	2	10/18/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $600,000

Issue Date FY: 2017 ( Subtotal = $600,000 )
2017	2017	CHICAGO HOUSE AND SOCIAL SERVICE AGENCY	1925 N CLYBOURN AVE STE 401	CHICAGO	IL	60614	COOK	USA	HIV Demonstration, Research, Public and Professional Education Projects	004	2	7/27/2017	NON-COMPETING CONTINUATION	$600,000
2017	2016	CHICAGO HOUSE AND SOCIAL SERVICE AGENCY	1925 N CLYBOURN AVE STE 401	CHICAGO	IL	60614	COOK	USA	HIV Demonstration, Research, Public and Professional Education Projects	003	1	1/31/2017	NEW	$0
2017	2016	CHICAGO HOUSE AND SOCIAL SERVICE AGENCY	1925 N CLYBOURN AVE STE 401	CHICAGO	IL	60614	COOK	USA	HIV Demonstration, Research, Public and Professional Education Projects	002	1	12/2/2016	NEW	$0
2017	2016	CHICAGO HOUSE AND SOCIAL SERVICE AGENCY	1925 N CLYBOURN AVE STE 401	CHICAGO	IL	60614	COOK	USA	HIV Demonstration, Research, Public and Professional Education Projects	001	1	11/18/2016	NEW	$0
2017	2016	CHICAGO HOUSE AND SOCIAL SERVICE AGENCY	1925 N CLYBOURN AVE STE 401	CHICAGO	IL	60614	COOK	USA	HIV Demonstration, Research, Public and Professional Education Projects	000	1	11/4/2016	NEW	$0
														Subtotal = $600,000

Issue Date FY: 2016 ( Subtotal = $200,000 )
2016	2016	CHICAGO HOUSE & SOCIAL SERVICES	1925 N. Clybourn Ave	CHICAGO	IL	60614	COOK	USA	HIV Demonstration, Research, Public and Professional Education Projects	000	1	8/26/2016	NEW	$200,000
														Subtotal = $200,000

Grand Total All Awards = $1,800,000

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Evaluation of TransLife Center: A Locally-Developed Combination Prevention Intervention for Transgender Women at High Risk of HIV Infection

Award Number: U01PS005140

ORGANIZATION: NATIONAL CENTER FOR PREVENTION SERVICES

OPDIV: CDC

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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