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NATURAL HISTORY PREVENTION OF VIRAL HEPATITIS IN ALASKA NATIVE PEOPLE

Award Number: U01PS001097
ORGANIZATION: NATIONAL CENTER FOR PREVENTION SERVICES
OPDIV: CDC
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/30/2008
PERIOD OF PERFORMANCE END DATE: 06/29/2014

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NATURAL HISTORY PREVENTION OF VIRAL HEPATITIS IN ALASKA NATIVE PEOPLE - Infections from hepatitis A virus (HAV) and hepatitis B virus (HBV) are significant problems in Alaska Natives. Hepatitis A and B vaccines have been routine immunizations in Alaska Natives since 1984 and 1994, respectively. Hepatitis A vaccine is administered to all children over 1 year of age in the US and catch-up hepatitis A virus (HAV) vaccine programs are employed in several states for all children. Hepatitis B vaccine has been administered to all neonates and children in the US for the past decade and to high risk individuals. In addition, chronic hepatitis B and C infections are significant causes of morbidity and mortality from hepatocellular carcinoma (HCC) and cirrhosis in high risk populations in the US. Alaska Natives have one of the highest rates of chronic HBV infection of any ethnic group in the US and a high rate of morbidity and mortality from hepatitis C infection. Not all persons with chronic hepatitis B or C will develop cirrhosis or HCC and the risk factors for progression are not completely elucidated. Population studies are needed to study risk factors for progression of chronic HBV and HCV. The Liver Disease and Hepatitis Program (LDHP) of the Alaska Native Tribal Health Consortium (ANTHC) working collaboratively with the Arctic Investigations Program (AIP) of the Centers for Disease Control and Prevention (CDC) has cohorts of persons who received hepatitis A and B vaccine as infants, children and adults available to determine long-term protection. In addition, the LDHP has recruited large cohorts of Alaska Natives with chronic hepatitis B or C infection. Relevance The strategy and cost effectiveness of hepatitis A and B vaccination programs depends on the supposition that these vaccines will provide long-term protection against hepatitis A and B infection. Also of concern is that persons with chronic hepatitis B or C infection are at-risk to cirrhosis and other serious liver disease. Using several Alaska Native cohorts, studies are proposed to (a) determine the duration of protection against hepatitis A and B infection in persons immunized 15-30 years ago and (b) better understand the treatment and natural history of chronic hepatitis B or C infection.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2012	ALASKA NATIVE TRIBAL HEALTH CONSORTIUM INC	4000 AMBASADOR DR	ANCHORAGE	AK	99508	ANCHORAGE	USA	Research, Prevention, and Education Programs on Lyme Disease in the United States	000	5	11/1/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $0 )
2014	2012	ALASKA NATIVE TRIBAL HEALTH CONSORTIUM	4141 DIPLOMACY DRIVE	ANCHORAGE	AK	99508	ANCHORAGE	USA	Research, Prevention, and Education Programs on Lyme Disease in the United States	000	5	11/14/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $0 )
2013	2012	ALASKA NATIVE TRIBAL HEALTH CONSORTIUM	4141 DIPLOMACY DRIVE	ANCHORAGE	AK	99508	ANCHORAGE	USA	Research, Prevention, and Education Programs on Lyme Disease in the United States	000	5	5/23/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2012 ( Subtotal = $369,661 )
2012	2012	ALASKA NATIVE TRIBAL HEALTH CONSORTIUM	4141 DIPLOMACY DRIVE	ANCHORAGE	AK	99508	ANCHORAGE	USA	Research, Prevention, and Education Programs on Lyme Disease in the United States	002	5	6/19/2012	NON-COMPETING CONTINUATION	$0
2012	2012	ALASKA NATIVE TRIBAL HEALTH CONSORTIUM	4141 DIPLOMACY DRIVE	ANCHORAGE	AK	99508	ANCHORAGE	USA	Research, Prevention, and Education Programs on Lyme Disease in the United States	001	5	6/11/2012	NON-COMPETING CONTINUATION	$150,000
2012	2012	ALASKA NATIVE TRIBAL HEALTH CONSORTIUM	4141 DIPLOMACY DRIVE	ANCHORAGE	AK	99508	ANCHORAGE	USA	Research, Prevention, and Education Programs on Lyme Disease in the United States	000	5	5/23/2012	NON-COMPETING CONTINUATION	$219,661
														Subtotal = $369,661

Issue Date FY: 2011 ( Subtotal = $232,000 )
2011	2011	ALASKA NATIVE TRIBAL HEALTH CONSORTIUM	4141 DIPLOMACY DRIVE	ANCHORAGE	AK	99508	ANCHORAGE	USA	Research, Prevention, and Education Programs on Lyme Disease in the United States	001	4	8/18/2011	NON-COMPETING CONTINUATION	$0
2011	2011	ALASKA NATIVE TRIBAL HEALTH CONSORTIUM	4141 DIPLOMACY DRIVE	ANCHORAGE	AK	99508	ANCHORAGE	USA	Research, Prevention, and Education Programs on Lyme Disease in the United States	000	4	6/28/2011	NON-COMPETING CONTINUATION	$232,000
														Subtotal = $232,000

Issue Date FY: 2010 ( Subtotal = $232,000 )
2010	2010	ALASKA NATIVE TRIBAL HEALTH CONSORTIUM	4141 DIPLOMACY DRIVE	ANCHORAGE	AK	99508	ANCHORAGE	USA	Research, Prevention, and Education Programs on Lyme Disease in the United States	001	3	6/21/2010	NON-COMPETING CONTINUATION	$232,000
2010	2009	ALASKA NATIVE TRIBAL HEALTH CONSORTIUM	4141 DIPLOMACY DRIVE	ANCHORAGE	AK	99508	ANCHORAGE	USA	Research, Prevention, and Education Programs on Lyme Disease in the United States	000	2	10/19/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $232,000

Issue Date FY: 2009 ( Subtotal = $232,000 )
2009	2009	ALASKA NATIVE TRIBAL HEALTH CONSORTIUM	4141 DIPLOMACY DRIVE	ANCHORAGE	AK	99508	ANCHORAGE	USA	Research, Prevention, and Education Programs on Lyme Disease in the United States	004	2	10/20/2009	NON-COMPETING CONTINUATION	$0
2009	2009	ALASKA NATIVE TRIBAL HEALTH CONSORTIUM	4141 DIPLOMACY DRIVE	ANCHORAGE	AK	99508	ANCHORAGE	USA	Research, Prevention, and Education Programs on Lyme Disease in the United States	000	2	5/11/2009	NON-COMPETING CONTINUATION	$232,000
2009	2009	ALASKA NATIVE TRIBAL HEALTH CONSORTIUM	4141 DIPLOMACY DRIVE	ANCHORAGE	AK	99508	ANCHORAGE	USA	Research, Prevention, and Education Programs on Lyme Disease in the United States	001	2	5/15/2009	NON-COMPETING CONTINUATION	$0
2009	2009	ALASKA NATIVE TRIBAL HEALTH CONSORTIUM	4141 DIPLOMACY DRIVE	ANCHORAGE	AK	99508	ANCHORAGE	USA	Research, Prevention, and Education Programs on Lyme Disease in the United States	003	2	9/11/2009	NON-COMPETING CONTINUATION	$0
2009	2009	ALASKA NATIVE TRIBAL HEALTH CONSORTIUM	4141 DIPLOMACY DRIVE	ANCHORAGE	AK	99508	ANCHORAGE	USA	Research, Prevention, and Education Programs on Lyme Disease in the United States	002	2	7/21/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $232,000

Issue Date FY: 2008 ( Subtotal = $217,000 )
2008	2008	ALASKA NATIVE TRIBAL HEALTH CONSORTIUM	4141 DIPLOMACY DRIVE	ANCHORAGE	AK	99508	ANCHORAGE	USA	Research, Prevention, and Education Programs on Lyme Disease in the United States	000	1	6/24/2008	NEW	$217,000
														Subtotal = $217,000

Grand Total All Awards = $1,282,661

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NATURAL HISTORY PREVENTION OF VIRAL HEPATITIS IN ALASKA NATIVE PEOPLE

Award Number: U01PS001097

ORGANIZATION: NATIONAL CENTER FOR PREVENTION SERVICES

OPDIV: CDC

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/30/2008

PERIOD OF PERFORMANCE END DATE: 06/29/2014

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