Thursday, October 16, 2025 10/16/2025

Hermanos de Luna y Sol: A community-based HIV prevention intervention

Award Number: U01MH136574
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2023
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Hermanos de Luna y Sol: A community-based HIV prevention intervention - Abstract The overall goal of our research is to reduce HIV-related health inequities among Latinx immigrant populations. We propose to determine the effectiveness of Hermanos de Luna y Sol (HLS), a community-based, group intervention delivered in Spanish, designed to reduce HIV sexual risk among Latinx immigrants who identify as gay/bisexual men or men who have sex with men (GBMSM). The study is designed as a quasi-experimental, community control, with Oakland, CA as the intervention group and Chicago, IL as the control. Assessments will be conducted at -3 and 0 mos., and follow-ups at 3, 6, and 12 mos. Participants (N=360; n=180 per city) will be recruited using Time-location sampling (a venue-based sampling designed to reduce sample bias). HLS, the intervention at the heart of this study, offers several novel features: it focuses on immigrant, Spanish- speaking populations; it addresses racism and homophobia as factors shaping HIV risk; and uses a community-based approach centered on community involvement (e.g., civic participation, volunteering) as a means to foster sexual health and community building. The study will help identify effective interventions to prevent HIV among Latinx immigrant GBMSM, a marginalized population for which HIV preventive interventions are severely lacking. This study capitalizes on an existing intervention designed for Spanish speaking populations; is the first of its kind to rigorously test the intervention’s effectiveness among Latinx immigrant GBMSM using a community control design. The study applies the best possible scientific approach to obtain estimates of intervention effectiveness. If successful, the intervention would be relatively easy to disseminate via community organizations and the Centers for Disease Control and Prevention. Ultimately, the study will help move forward efforts to reduce racial/ethnic health inequities, one of the nation’s major public health priorities. This proposal is directly relevant to the RFA on Transformative Research to Address Health Disparities and Advance Health Equity at Minority serving Institutions. The project is led by SFSU – a Hispanic Serving Institution-- in collaboration with two Latinx community-based organizations: La Familia and Chicago Queer Latinx Collaborative. We are a multidisciplinary research team with the depth and breadth of experience on HIV prevention with Latinx and GBMSM communities to successfully conduct the study. All senior personnel are of Latin American descent, fully bilingual (Spanish and English), and three of them are women. The proposed study is strongly aligned with NIH UNITED Initiative of fostering racial equity and inclusion in biomedical research and is responsive to priority areas of multiple NIH institutes and centers, such NIMHD, NIMH, and the Office of AIDS Research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	SAN FRANCISCO STATE UNIVERSITY	1600 HOLLOWAY AVE	SAN FRANCISCO	CA	94132	SAN FRANCISCO	USA	Mental Health Research Grants	002	2	8/28/2025	NON-COMPETING CONTINUATION	$0
2025	2024	SAN FRANCISCO STATE UNIVERSITY	1600 HOLLOWAY AVE	SAN FRANCISCO	CA	94132	SAN FRANCISCO	USA	Mental Health Research Grants	001	2	7/11/2025	NON-COMPETING CONTINUATION	$0
2025	2024	SAN FRANCISCO STATE UNIVERSITY	1600 HOLLOWAY AVE	SAN FRANCISCO	CA	94132	SAN FRANCISCO	USA	Mental Health Research Grants	000	2	3/24/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $780,747 )
2024	2024	SAN FRANCISCO STATE UNIVERSITY	1600 HOLLOWAY AVE	SAN FRANCISCO	CA	94132	SAN FRANCISCO	USA	Mental Health Research Grants	002	2	9/5/2024	NON-COMPETING CONTINUATION	$780,747
2024	2023	SAN FRANCISCO STATE UNIVERSITY	1600 HOLLOWAY AVE	SAN FRANCISCO	CA	94132	SAN FRANCISCO	USA	Mental Health Research Grants	001	1	8/29/2024	NEW	$0
2024	2023	SAN FRANCISCO STATE UNIVERSITY	1600 HOLLOWAY AVE	SAN FRANCISCO	CA	94132	SAN FRANCISCO	USA	Mental Health Research Grants	000	1	8/16/2024	NEW	$0
														Subtotal = $780,747

Issue Date FY: 2023 ( Subtotal = $718,434 )
2023	2023	SAN FRANCISCO STATE UNIVERSITY	1600 HOLLOWAY AVE BUILDING NAD ROOM 358C	SAN FRANCISCO	CA	94132	SAN FRANCISCO	USA	Mental Health Research Grants	000	1	9/19/2023	NEW	$718,434
														Subtotal = $718,434

Grand Total All Awards = $1,499,181

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Hermanos de Luna y Sol: A community-based HIV prevention intervention

Award Number: U01MH136574

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2023

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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