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Person-centered diagnostics and prediction for child dysregulatory psychopathology using novel phenotypes

Award Number: U01MH135970
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Person-centered diagnostics and prediction for child dysregulatory psychopathology using novel phenotypes - Project Summary This U01 proposal is submitted in response to the NIMH IMPACT RFA (RFA-MH-23-105). It will extend research efforts to both define novel, deployable behavioral phenotypes (highlighting cognitive and emotional transdiagnostic measures) and develop and test diagnostic and prognostic prediction models, using advanced analytics, within the clinic setting. It does so for children aged 7-17, presenting with common forms of psychopathology, characterized by dysregulation of attention, behavior, and/or emotion. Aim 1 uses established longitudinal research cohorts to further refine computational phenotypes for cognition (executive functions, alertness/arousal) and low-cost trait ratings relevant to emotional regulation and valence, and in combination with key environmental variables, tests their cross-sectional and longitudinal predictive utility using machine learning models. Aim 2 uses large electronic medical record (EMR) data to refine sophisticated neural network models to enhance mental health diagnostics and outcome prediction in children. Aims 3 and 4 entail new data collection of several thousand patients in four pediatric and psychiatry clinic sites around the country, and then combines and extends findings from Aims 1 and 2 to test their diagnostic and prognostic effectiveness in these diverse patient populations. The study is significant in its potential to open the way for clinical care to benefit from years of scientific progress in phenotype refinement that are low cost and deployable. It is further significant in its potential to harvest from existing EMR data far more clinically useful prediction algorithms than are currently available. The inclusion of sequential Bayesian logic for aiding clinicians in deciding which cases require additional assessment and which do not will be transformative in opening a path for significant savings in cost and clinician time by improving efficiency of care. The ability to better predict critical outcomes, such as worsening of mental health symptoms, suicidality, or increased resource utilization is urgent and will be addressed in our work. This project is innovative in combining large machine learning models from EMR data with similar models using novel research phenotypes and will be the first prospective test of these models in patients recruited from active clinics in multiple locations to evaluate generalizability. Further significance and innovation are added by careful attention to the role of environmental adversity and extensive plans to minimize or overcome the asynchronous benefit of such efforts to historically under-served and under-represented populations. The project directly, significantly, and with innovation addresses the goals and purpose of the IMPACT RFA by aiming to demonstrate how novel behavioral phenotypes can enhance clinical care even as maximum value is extracted from EMR data already in hand.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,319,688 )
2025	2025	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Mental Health Research Grants	000	2	3/27/2025	NON-COMPETING CONTINUATION	$3,319,688
														Subtotal = $3,319,688

Issue Date FY: 2024 ( Subtotal = $2,625,977 )
2024	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Mental Health Research Grants	001	1	5/16/2024	NEW	$0
2024	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Mental Health Research Grants	000	1	5/13/2024	NEW	$2,625,977
														Subtotal = $2,625,977

Grand Total All Awards = $5,945,665

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Person-centered diagnostics and prediction for child dysregulatory psychopathology using novel phenotypes

Award Number: U01MH135970

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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