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Trajectories and Predictors in the Clinical High Risk for Psychosis Population: Prediction Scientific Global Consortium (PRESCIENT)

Award Number: U01MH124631
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/08/2020
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Trajectories and Predictors in the Clinical High Risk for Psychosis Population: Prediction Scientific Global Consortium (PRESCIENT) - PROJECT SUMMARY/ABSTRACT Psychotic illnesses usually first emerge in young people and result in widespread suffering, protracted disability, premature death, and a huge economic burden. Early intervention represents a vital strategy to reduce this burden. Psychotic disorders are preceded by a prodromal period of distress, impaired functioning and subthreshold symptomatology. Our original research operationally defined the Clinical High Risk (CHR) state, which predicts a substantially increased risk of incipient psychosis. There is substantial heterogeneity in clinical trajectories in the CHR population. The field is currently unable to reliably identify these trajectories early on, particularly on an individual patient level. The models to date (using clinical, neurocognitive, neuroimaging, neurobiological and genetic data) have yielded only modest predictive value for conversion to psychotic disorder and other outcomes. This presents a challenge for targeted intervention development and developing robust aetiological models. The current project seeks to develop more robust prediction models for a range of outcomes in the CHR population (conversion to psychotic disorder, persistent and incident non-psychotic disorder, non-remission of CHR status, persistent negative symptoms, full recovery, functional outcome) and introduce validated tools for use in clinical practice. These prediction models and associated clinical tools will be developed using multimodal data consisting of biomarkers (neuroimaging, neurocognition, neurophysiology, biospecimens), clinical data, and digital momentary assessments. The prediction models will facilitate selection of CHR patients for enrolment in clinical trials, serve as measures of early treatment effects, and monitor disease progression and clinical and functional outcomes. The project is based on four pillars: 1. An existing nationwide clinical infrastructure (network) to support recruitment and follow up of a large cohort of CHR young people (n=1000) over a short timeframe (2 year recruitment period, 2 year follow up), as well as a clinical comparison group (n=300). 2. Use of this dataset to: validate existing and forthcoming prediction models and develop new, more refined prediction models using recent methodological advances and exploratory biomarkers. 3. Recruitment of an independent CHR sample across international centres for external validation of models generated in the Australian network to ensure generalizability of findings. Alternatively, these sites could be used as additional spokes in the network, with alternative data sets used for external validation purposes (see 2.5.4). This network of sites and research specialization will provide the clinical research infrastructure for future treatment trials in this clinical population informed by findings of the current program of work. 4. Unique track record as pioneers of the CHR field and expertise in state-of-the-art predictive modelling, including pioneering new approaches to prediction (dynamic prediction, multimodal probabilistic prediction, network theory), and use of digital technologies to support collection of requisite data. We also have unrivalled track record in management of multisite research networks in this clinical population and rapid recruitment locally, nationally, and internationally.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,357,615 )
2025	2025	UNIVERSITY OF MELBOURNE	RAYMOND PRIESTLEY BLDG UNIV OF MELB	MELBOURNE	VICTORIA			AUS	Mental Health Research Grants	006	5	8/12/2025	SUPPLEMENT FOR EXPANSION	$328,218
2025	2025	UNIVERSITY OF MELBOURNE	RAYMOND PRIESTLEY BLDG UNIV OF MELB	MELBOURNE	VICTORIA			AUS	Mental Health Research Grants	003	5	8/12/2025	SUPPLEMENT FOR EXPANSION	$31,999
2025	2025	UNIVERSITY OF MELBOURNE	RAYMOND PRIESTLEY BLDG UNIV OF MELB	MELBOURNE	VICTORIA			AUS	Mental Health Research Grants	007	5	8/12/2025	SUPPLEMENT FOR EXPANSION	$116,345
2025	2025	UNIVERSITY OF MELBOURNE	RAYMOND PRIESTLEY BLDG UNIV OF MELB	MELBOURNE	VICTORIA			AUS	Mental Health Research Grants	001	5	8/12/2025	SUPPLEMENT FOR EXPANSION	$109,715
2025	2025	UNIVERSITY OF MELBOURNE	RAYMOND PRIESTLEY BLDG UNIV OF MELB	MELBOURNE	VICTORIA			AUS	Mental Health Research Grants	000	5	8/8/2025	NON-COMPETING CONTINUATION	$2,494,326
2025	2025	UNIVERSITY OF MELBOURNE	RAYMOND PRIESTLEY BLDG UNIV OF MELB	MELBOURNE	VICTORIA			AUS	Mental Health Research Grants	002	5	8/12/2025	SUPPLEMENT FOR EXPANSION	$147,217
2025	2025	UNIVERSITY OF MELBOURNE	RAYMOND PRIESTLEY BLDG UNIV OF MELB	MELBOURNE	VICTORIA			AUS	Mental Health Research Grants	008	5	8/13/2025	NON-COMPETING CONTINUATION	$0
2025	2025	UNIVERSITY OF MELBOURNE	RAYMOND PRIESTLEY BLDG UNIV OF MELB	MELBOURNE	VICTORIA			AUS	Mental Health Research Grants	005	5	8/12/2025	SUPPLEMENT FOR EXPANSION	$20,763
2025	2025	UNIVERSITY OF MELBOURNE	RAYMOND PRIESTLEY BLDG UNIV OF MELB	MELBOURNE	VICTORIA			AUS	Mental Health Research Grants	004	5	8/12/2025	SUPPLEMENT FOR EXPANSION	$109,032
														Subtotal = $3,357,615

Issue Date FY: 2024 ( Subtotal = $5,775,154 )
2024	2024	UNIVERSITY OF MELBOURNE	RAYMOND PRIESTLEY BLDG UNIV OF MELB	MELBOURNE	VICTORIA			AUS	Mental Health Research Grants	000	4	7/8/2024	NON-COMPETING CONTINUATION	$5,775,154
														Subtotal = $5,775,154

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Mental Health Research Grants	000	3	11/7/2022	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Mental Health Research Grants	002	3	8/11/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Mental Health Research Grants	001	3	11/22/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $7,433,029 )
2022	2022	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Mental Health Research Grants	001	3	8/17/2022	NON-COMPETING CONTINUATION	$7,433,029
2022	2021	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Mental Health Research Grants	000	2	10/27/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $7,433,029

Issue Date FY: 2021 ( Subtotal = $7,430,292 )
2021	2021	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Mental Health Research Grants	002	2	7/8/2021	NON-COMPETING CONTINUATION	$6,024,993
2021	2021	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Mental Health Research Grants	004	2	9/23/2021	SUPPLEMENT FOR EXPANSION	$1,499,864
2021	2021	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Mental Health Research Grants	003	2	7/30/2021	NON-COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Mental Health Research Grants	001	1	2/12/2021	NEW	$0
2021	2020	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Mental Health Research Grants	000	1	12/15/2020	NEW	-$94,565
														Subtotal = $7,430,292

Issue Date FY: 2020 ( Subtotal = $4,821,827 )
2020	2020	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC	3010		AUS	Mental Health Research Grants	000	1	9/8/2020	NEW	$4,821,827
														Subtotal = $4,821,827

Grand Total All Awards = $28,817,917

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Trajectories and Predictors in the Clinical High Risk for Psychosis Population: Prediction Scientific Global Consortium (PRESCIENT)

Award Number: U01MH124631

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/08/2020

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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