Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

3/3 - Whole Genome Sequencing for Schizophrenia and Bipolar Disorder in the GPC

Award Number: U01MH105573
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/19/2014
PERIOD OF PERFORMANCE END DATE: 05/31/2019

Group Awards By:

View Award Description

3/3 - Whole Genome Sequencing for Schizophrenia and Bipolar Disorder in the GPC - Project Summary The goal of this collaborative project among investigators led by Drs. Michael Boehnke at the University of Michigan, Steven McCarroll of Harvard University and the Broad Institute, and Carlos Pato at the University of Southern California, is to use high-throughput DNA sequencing to identify genes and pathways that contribute to the risk for schizophrenia and bipolar disorder, and to construct a data resource for future genetic studies of these and other psychiatric disorders. This proposal builds on active collaborations among our groups on these important disorders and more generally on our experience in building genome variation resources, such as the 1000 Genomes Project, that are used throughout human genetics. Our research team combines strengths in high-throughput genetics and genomics, development and application of innovative computational and statistical analyses that maximize the benefits of new technologies, and leadership of large scientific consortia. In four Specific Aims, we propose whole genome sequencing (at ~30x coverage) and statistical analysis of 10,000 well-phenotyped and re-contactable individuals from the Genomic Psychiatry Cohort (GPC), equally divided among schizophrenia cases, bipolar cases, and psychiatrically normal controls, and comprised of equal numbers of European-Ancestry (EA), African-Ancestry (AA), and Latino individuals. We will carry out association analysis comparing schizophrenia cases to controls, bipolar cases to controls, and the combined cases to controls in the resulting sequence data, and by collaboration and meta-analysis with other investigators with relevant sequence data that become available. We will also use these sequence data as part of a reference panel to impute into tens of thousands of other genomes in the broader Psychiatric GWAS Consortium (PGC) data to allow association analysis based on substantially larger numbers of individuals. Finally, we will share data and methods to support similar studies of other psychiatric phenotypes and more broadly across the scientific community. The successful completion of these aims will provide new insights into molecular etiology that could catalyze breakthroughs in the prevention, treatment, and diagnosis of schizophrenia and bipolar disorder.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = -$131,000 )
2020	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Mental Health Research Grants	001	5	12/5/2019	SUPPLEMENT FOR EXPANSION	-$58,100
2020	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Mental Health Research Grants	000	5	12/5/2019	NON-COMPETING CONTINUATION	-$72,900
														Subtotal = -$131,000

Issue Date FY: 2018 ( Subtotal = $58,100 )
2018	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Mental Health Research Grants	000	5	6/11/2018	SUPPLEMENT FOR EXPANSION	$58,100
														Subtotal = $58,100

Issue Date FY: 2017 ( Subtotal = $232,552 )
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Mental Health Research Grants	000	5	6/16/2017	NON-COMPETING CONTINUATION	$232,552
														Subtotal = $232,552

Issue Date FY: 2016 ( Subtotal = $232,552 )
2016	2016	UNIVERSITY HOSPITAL OF DOWNSTATE MEDICAL CENTER	450 CLARKSON AVENUE	NEW YORK-KINGS	NY	11203		USA	Mental Health Research Grants	000	4	6/4/2016	NON-COMPETING CONTINUATION	$161,944
2016	2016	UNIVERSITY HOSPITAL OF DOWNSTATE MEDICAL CENTER	450 CLARKSON AVENUE	NEW YORK-KINGS	NY	11203		USA	Mental Health Research Grants	001	4	7/6/2016	SUPPLEMENT FOR EXPANSION	$70,608
														Subtotal = $232,552

Issue Date FY: 2015 ( Subtotal = $161,944 )
2015	2015	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Mental Health Research Grants	002	2	8/25/2015	NON-COMPETING CONTINUATION	-$165,454
2015	2015	UNIVERSITY HOSPITAL OF DOWNSTATE MEDICAL CENTER	450 CLARKSON AVENUE	NEW YORK-KINGS	NY	11203		USA	Mental Health Research Grants	001	3	8/25/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$161,944
2015	2015	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Mental Health Research Grants	000	2	6/11/2015	NON-COMPETING CONTINUATION	$165,454
														Subtotal = $161,944

Issue Date FY: 2014 ( Subtotal = $165,454 )
2014	2014	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Mental Health Research Grants	000	1	9/19/2014	NEW	$165,454
														Subtotal = $165,454

Grand Total All Awards = $719,602

Top

All Categories

About

Search

Reports

Data Submission

Award Information

3/3 - Whole Genome Sequencing for Schizophrenia and Bipolar Disorder in the GPC

Award Number: U01MH105573

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/19/2014

PERIOD OF PERFORMANCE END DATE: 05/31/2019

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer