Tuesday, December 16, 2025 12/16/2025

Statistical adjustments of sample representation in community-level estimates of COVID-19 transmission and immunity

Award Number: U01MD017867
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2022
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Statistical adjustments of sample representation in community-level estimates of COVID-19 transmission and immunity - Abstract Throughout the COVID-19 pandemic, government policy and healthcare implementation responses have been guided by reported positivity rates and vaccination rates in the community. The selection bias of these test data questions their validity as measures of the actual viral incidence in the community and as predictors of clinical burden. Publicly available vaccination data are frequently cited as a proxy for population immunity, but this metric ignores the effects of naturally-acquired immunity. The health disparities concerning asymptomatic and symptomatic patients are not yet studied. The proposal develops a valid metric to estimate the true viral incidence and naturally/vaccine-acquired immunity prevalence in the community, examine the health disparities and social inequality, and monitor the epidemic over time as an operational surveillance system. The approach collects routine testing data on SARS-CoV-2 exposure and antibody seropositivity among patients in a hospital system and performs statistical adjustments of sample representation using multilevel regression and poststratiﬁcation (MRP), which adjusts for measured differences between the sample and population and also yields stable small area estimates. The data collection and analysis procedure can provide information to entire communities with generalizability and focus on burdens within speciﬁc demographics, with close attention to vulnerable populations on disparities across health outcomes, social determinants, and behaviors. In particular, the research will yield group-speciﬁc estimates of disparities with respect to asymptomatic and symptomatic patients and how these discrepancies may impact the socio-demographically dependent spread of disease and its subsequent treatment. The MRP adjustment will be made publicly accessible via a web interface and promote broad investigations with integrated data sources toward a national study.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Minority Health and Health Disparities Research	000	4	10/8/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $524,486 )
2025	2025	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Minority Health and Health Disparities Research	000	4	1/2/2025	NON-COMPETING CONTINUATION	$524,486
														Subtotal = $524,486

Issue Date FY: 2024 ( Subtotal = $582,763 )
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Minority Health and Health Disparities Research	001	3	5/25/2024	NON-COMPETING CONTINUATION	$58,277
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Minority Health and Health Disparities Research	000	3	12/5/2023	NON-COMPETING CONTINUATION	$524,486
														Subtotal = $582,763

Issue Date FY: 2023 ( Subtotal = $562,066 )
2023	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Minority Health and Health Disparities Research	001	2	1/28/2023	NON-COMPETING CONTINUATION	$562,066
2023	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Minority Health and Health Disparities Research	002	1	1/31/2023	NEW	$0
2023	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Minority Health and Health Disparities Research	000	1	1/19/2023	NEW	$0
														Subtotal = $562,066

Issue Date FY: 2022 ( Subtotal = $578,172 )
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Minority Health and Health Disparities Research	001	1	6/6/2022	NEW	$0
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Minority Health and Health Disparities Research	000	1	4/1/2022	NEW	$578,172
														Subtotal = $578,172

Grand Total All Awards = $2,247,487

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Statistical adjustments of sample representation in community-level estimates of COVID-19 transmission and immunity

Award Number: U01MD017867

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2022

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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