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A Pragmatic Trial of An Adaptive eHealth HIV Prevention Program for Diverse Adolescent MSM

Award Number: U01MD011281
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/28/2016
PERIOD OF PERFORMANCE END DATE: 02/28/2023

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A Pragmatic Trial of An Adaptive eHealth HIV Prevention Program for Diverse Adolescent MSM - Project Summary Adolescent (ages 13-18) men who have sex with men (AMSM) experience a dramatic health disparity as they represent 2% of young people but account for almost 80% of HIV diagnoses. Despite this disproportionate burden, there is a conspicuous lack of evidence-based HIV prevention programs. Implementation issues are critical as traditional HIV prevention delivery channels (community organizations, schools, parents), have significant limitations when it comes to AMSM. eHealth interventions represent an excellent modality for delivering AMSM-specific intervention material where youth “are.” We should not continue to deliver the same intervention when a participant is not responding. Rather, stepped-care strategies increase in intensity to meet the needs of those who do not respond to a less intense intervention. Using a Sequential Multiple Assignment Randomized Trial (SMART) design, we will evaluate the impact of a package of increasingly intensive interventions that have already shown evidence of efficacy with diverse adolescent and young adult MSM. The SMART design is an ideal approach to achieve the goals of this RFA because SMART designs mimic treatment decisions as they are made in real-world clinical settings. Collectively we brand our package of eHealth interventions as the SMART Program (Sexual Minority Adolescent Risk Taking). The Program package includes: (1) a universally-delivered, brief, online sexual health education program designed for sexual and gender minority youth regardless of whether they are sexually active (Queer Sex Ed); (2) a more intensive online intervention designed for diverse AMSM engaging in HIV transmission risk behaviors (Keep It Up!), and (3) the most intensive is a motivational interviewing (MI) intervention that will be delivered by MI therapists via online videochat (Young Men's Health Project). We will evaluate SMART Program impact and inform future implementation with three specific aims. Aim 1 is to test impact of the SMART Program and its constituent components on reducing HIV risk and increasing testing among. We will developmentally adapt existing content for AMSM using the ADAPT-ITT framework and linguistically adapt the SMART Program to Spanish speaking Latino AMSM. We will enroll a national sample of 1,878 diverse AMSM and test the efficacy of the Program using a SMART design. Aim 2 is to test if the SMART Program has differential efficacy across important sub-groups of AMSM based on race/ethnicity, urban/rural, age, socioeconomic status, and language. Aim 3 is to evaluate the delivery of the SMART Program nationally to inform its implementation and cost-effectiveness. To minimize the science-practice gap, we will utilize mixed methods to identify facilitators and barriers to the implementation of the SMART Program and its core components by collecting measures from the RE-AIM framework and performing cost analysis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$43,113 )
2023	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	000	5	9/11/2023	NON-COMPETING CONTINUATION	-$43,113
														Subtotal = -$43,113

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	000	5	1/25/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $1,639,110 )
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	001	5	3/6/2020	NON-COMPETING CONTINUATION	$1,639,110
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	002	5	4/27/2020	NON-COMPETING CONTINUATION	$0
2020	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	003	4	5/11/2020	NON-COMPETING CONTINUATION	$0
2020	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	000	4	1/16/2020	NON-COMPETING CONTINUATION	$0
2020	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	004	4	6/24/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,639,110

Issue Date FY: 2019 ( Subtotal = $2,019,462 )
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	003	4	9/25/2019	SUPPLEMENT FOR EXPANSION	$125,000
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	002	4	9/11/2019	NON-COMPETING CONTINUATION	$0
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	001	4	2/11/2019	NON-COMPETING CONTINUATION	$1,894,462
2019	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	000	3	10/30/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,019,462

Issue Date FY: 2018 ( Subtotal = $2,005,882 )
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	003	3	6/21/2018	SUPPLEMENT FOR EXPANSION	$10,736
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	000	3	2/21/2018	NON-COMPETING CONTINUATION	$1,708,671
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	001	3	2/22/2018	SUPPLEMENT FOR EXPANSION	$96,625
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	004	3	8/1/2018	NON-COMPETING CONTINUATION	$0
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	002	3	6/21/2018	NON-COMPETING CONTINUATION	$189,850
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	005	3	9/6/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,005,882

Issue Date FY: 2017 ( Subtotal = $2,005,661 )
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	001	2	6/29/2017	NON-COMPETING CONTINUATION	$193,300
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	000	2	2/10/2017	NON-COMPETING CONTINUATION	$1,739,680
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	002	2	9/22/2017	SUPPLEMENT FOR EXPANSION	$72,681
														Subtotal = $2,005,661

Issue Date FY: 2016 ( Subtotal = $1,987,674 )
2016	2016	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	001	1	7/29/2016	NEW	$19,726
2016	2016	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	000	1	7/28/2016	NEW	$1,967,948
														Subtotal = $1,987,674

Grand Total All Awards = $9,614,676

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A Pragmatic Trial of An Adaptive eHealth HIV Prevention Program for Diverse Adolescent MSM

Award Number: U01MD011281

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/28/2016

PERIOD OF PERFORMANCE END DATE: 02/28/2023

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