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Core_Apt Measure of PCR-based Influenza Vaccine Effectiveness in Inpatient Adults

Award Number: U01IP000972
ORGANIZATION: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES(NCIRD)
OPDIV: CDC
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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¿ DESCRIPTION (provided by applicant): Influenza viruses are constantly changing, requiring the reformulation of vaccines every year. Accurately estimating influenza vaccine effectiveness in preventing influenza infection is critical in order to evaluate the protection provided by annua, nationwide vaccination programs. Our long-term goal is to discover more advanced strategies to measure vaccine effectiveness, to potentially reduce the overall burden of influenza infection. The effectiveness of influenza vaccines with the ACIP recommended universal immunization strategy in the Scott and White Memorial Hospital -Temple Population Research Area (SWH-TPRA) adult source population will be systematically investigated. The objective of the proposed work is to explore strategies for measuring vaccine effectiveness against lab-confirmed influenza (VE-LCI) in adult inpatients, including the elderly, who have the highest hospitalization rates. This includes the identification, implementation and evaluation of innovative, feasible, and sustainable strategies for measuring VE-LCI in persons aged 18 years or older in acute inpatient care settings. The central hypothesis is that timely and efficient measurement of VE- LCI in adult inpatients is feasible and sustainable in the U.S. This hypothesis will be tested by pursuing three specific aims: 1) Identify innovative, feasible, and sustainable strategies to measure VE-LCI in a timely and efficient manner for persons = 18 years admitted with an acute respiratory illness (ARI) in acute inpatient care settings, 2) Implement the above strategies to measure VE-LCI for adult inpatients with ARI, and 3) Evaluate the above strategies to measure VE-LCI for adult inpatients with ARI. To achieve these goals, VE-LCI will be determined in adults admitted to SWMH with ARI who test positive for influenza A and/or B by the real-time polymerase chain reaction (RT-PCR) assay. The odds of being vaccinated against influenza for PCR-confirmed cases will be compared to age-matched PCR-negative controls, after adjusting for confounders. During 2015- 2016 through 2019-2020, 300 patients and 800 adults admitted to SWMH with an ARI will be eligible to participate in the BSWH CDC VE-LCI adult inpatient study, respectively. Using a test-negative study design, VE-LCI for adult inpatients with ARI will be measured. Influenza immunization rates will be calculated for the RT-PCR confirmed cases and test negative controls, adjusting VE-LCI for confounders. The approach is innovative because effective measures of the public health impact of increasing influenza immunization on burden of illness will be defined. The proposed research is significant, because it will support improved understanding of timely and efficient measures of VE-LCI, which in turn will support the goal of reducing influenza-associated health burdens.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$524,943 )
2022	2020	Scott & White Memorial Hospital	2401 31ST	TEMPLE	TX	76504	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	04	5	11/13/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	-$524,943
2022	2019	Scott & White Memorial Hospital	2401 31ST	TEMPLE	TX	76504	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	04	5	11/13/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2018	Scott & White Memorial Hospital	2401 31ST	TEMPLE	TX	76504	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	04	5	11/13/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2017	Scott & White Memorial Hospital	2401 31ST	TEMPLE	TX	76504	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	04	5	11/13/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2016	Scott & White Memorial Hospital	2401 31ST	TEMPLE	TX	76504	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	04	5	11/13/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2015	Scott & White Memorial Hospital	2401 31ST	TEMPLE	TX	76504	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	04	5	11/13/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = -$524,943

Issue Date FY: 2021 ( Subtotal = -$33,264 )
2021	2016	Scott & White Memorial Hospital	2401 31ST	TEMPLE	TX	76504	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	04	5	6/16/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	-$33,264
														Subtotal = -$33,264

Issue Date FY: 2020 ( Subtotal = $938,970 )
2020	2020	Scott & White Memorial Hospital	2401 31ST	TEMPLE	TX	76504	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	02	5	5/28/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$500,000
2020	2020	Scott & White Memorial Hospital	2401 31ST	TEMPLE	TX	76504	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	03	5	7/15/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$438,970
2020	2019	Scott & White Memorial Hospital	2401 31ST	TEMPLE	TX	76504	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	01	5	5/14/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2020	2019	Scott & White Memorial Hospital	2401 31ST	TEMPLE	TX	76504	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	02	5	5/28/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $938,970

Issue Date FY: 2019 ( Subtotal = $700,000 )
2019	2019	Scott & White Memorial Hospital	2401 S 31st St	Temple	TX	76508	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	00	5	5/31/2019	NON-COMPETING CONTINUATION	$700,000
2019	2018	Scott & White Memorial Hospital	2401 S 31st St	Temple	TX	76508	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	01	4	2/4/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2016	Scott & White Memorial Hospital	2401 S 31st St	Temple	TX	76508	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	01	4	2/4/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $700,000

Issue Date FY: 2018 ( Subtotal = $700,000 )
2018	2018	Scott & White Memorial Hospital	2401 S 31st St	Temple	TX	76508	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	00	4	7/9/2018	NON-COMPETING CONTINUATION	$700,000
2018	2017	Scott & White Memorial Hospital	2401 S 31st St	Temple	TX	76508	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	01	3	1/30/2018	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2018	2016	Scott & White Memorial Hospital	2401 S 31st St	Temple	TX	76508	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	04	2	3/26/2018	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $700,000

Issue Date FY: 2017 ( Subtotal = $450,000 )
2017	2017	SCOTT & WHITE MEMORIAL HOSPITAL	2401 S 31ST ST	TEMPLE	TX	76508	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	002	3	7/31/2017	NON-COMPETING CONTINUATION	$450,000
2017	2016	SCOTT & WHITE MEMORIAL HOSPITL	2401 S 31ST ST	TEMPLE	TX	76504	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	000	2	1/10/2017	SUPPLEMENT FOR EXPANSION	-$419,098
2017	2016	SCOTT & WHITE MEMORIAL HOSPITL	2401 S 31ST ST	TEMPLE	TX	76504	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	001	2	3/1/2017	SUPPLEMENT FOR EXPANSION	$419,098
														Subtotal = $450,000

Issue Date FY: 2016 ( Subtotal = $450,000 )
2016	2016	SCOTT & WHITE MEMORIAL HOSPITAL	2401 SOUTH 31ST STREET	TEMPLE	TX	76508	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	002	2	8/2/2016	SUPPLEMENT FOR EXPANSION	$419,098
2016	2016	SCOTT & WHITE MEMORIAL HOSPITAL	2401 SOUTH 31ST STREET	TEMPLE	TX	76508	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	001	2	8/1/2016	NON-COMPETING CONTINUATION	$30,902
2016	2015	SCOTT & WHITE MEMORIAL HOSPITAL	2401 SOUTH 31ST STREET	TEMPLE	TX	76508	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	000	1	10/29/2015	NEW	$0
														Subtotal = $450,000

Issue Date FY: 2015 ( Subtotal = $300,000 )
2015	2015	SCOTT & WHITE MEMORIAL HOSPITAL	2401 SOUTH 31ST STREET	TEMPLE	TX	76508	BELL	USA	Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases	000	1	7/28/2015	NEW	$300,000
														Subtotal = $300,000

Grand Total All Awards = $2,980,764

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Core_Apt Measure of PCR-based Influenza Vaccine Effectiveness in Inpatient Adults

Award Number: U01IP000972

ORGANIZATION: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES(NCIRD)

OPDIV: CDC

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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