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Enhanced Surveillance for New Vaccine Preventable Diseases

Award Number: U01IP000460
ORGANIZATION: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES(NCIRD)
OPDIV: CDC
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Enhanced Surveillance for New Vaccine Preventable Diseases Project Summary Children's Mercy Hospitals and Clinics (CMH), located in Kansas City, MO. is a large, comprehensive pediatric medical center and the only free standing children's hospital between St. Louis and Denver. CMH provides state-of-the-art care for children from 18 primary counties in Missouri, Kansas and adjoining areas with a total population approaching 2.5 million. In 2009 CMH established an active population-based surveillance system through Centers for Disease Control and Prevention (CDC) funding mechanism from American Recovery and Reinvestment Act. The CMH active surveillance system can be effectively utilized to study the impact of new or upcoming vaccines and policies relating to vaccination. Our active surveillance system will monitor community rates of acute gastroenteritis (AGE) and acute respiratory illness (ARI) by prospectively enrolling children year-round in both our outpatient and inpatient locations. Our two model projects are described below: First model project: Our first model project will examine rotavirus vaccination effectiveness through population-based, laboratory confirmed, active surveillance. Specifically, we will prospectively monitor rotavirus disease burden and characterize rotavirus genotypes. Parents of the AGE children and control subjects will be consented to participate in the study; a stool specimen (only for AGE children) and permission to access vaccination record will be requested. Stool specimen is tested in CMH laboratory for rotavirus antigen and positive specimens will be shipped to CDC for genotyping. Rotavirus vaccination record will be accessed through Kansas and Missouri vaccination registries, CMH electronic medical records or by contacting primary care provider. Rotavirus vaccine effectiveness will be calculated by comparing rotavirus positive to rotavirus negative or control children. Second model project: The goal of our second model project is to understand the epidemiology of human parechovirus (HPeV) associated AGE. HPeV is a newly described virus closely related to enterovirus (EV). The majority of the newly described HPeV types (17 types) have been isolated from diarrheal stool specimens obtained from children around the world. HPeV is also associated with respiratory illness and central nervous system infection in infants. The evaluation of the burden of HPeV associated infections in the US currently is limited to a passive surveillance system and a few ad hoc studies in academic centers. We have recently demonstrated a high burden of HPeV3-CNS infections (18%) in US children during 2007 and 2009 (Selvarangan et al 2010; appendix 3). The proposed NVSN network can be effectively utilized to understand the epidemiology of this newly recognized viral pathogen. The specific questions we can address include: ¿ Incidence of HPeV in diarrheal and respiratory stool specimens in children ¿ Clinical presentation associated with HPeV infections ¿ Discovery of new HPeV types in collaboration with CDC, Picornavirus laboratory ¿ Association of currently circulating HPeV types with specific illnesses CMH's previous success enrolling subjects in NVSN demonstrates our capabilities. Notably, CMH has the flexibility and capability of extending surveillance to other vaccine preventable diseases, demonstrated ability to collect stool specimens and rotavirus vaccination data on subjects enrolled in the study, ability to access hospital admission data, and two years of rotavirus surveillance data from our participation in NVSN.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = -$75,727 )
2020	2015	Children's Mercy Hospital, The	2401 Gillham Rd	Kansas City	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	18	5	10/25/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	-$75,727
2020	2014	Children's Mercy Hospital, The	2401 Gillham Rd	Kansas City	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	18	5	10/25/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2020	2013	Children's Mercy Hospital, The	2401 Gillham Rd	Kansas City	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	18	5	10/25/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2020	2012	Children's Mercy Hospital, The	2401 Gillham Rd	Kansas City	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	18	5	10/25/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2020	2011	Children's Mercy Hospital, The	2401 Gillham Rd	Kansas City	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	18	5	10/25/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = -$75,727

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	000	5	11/15/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	000	5	7/13/2016	SUPPLEMENT FOR EXPANSION	$0
2016	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	001	5	7/19/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $1,099,997 )
2015	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	012	5	9/29/2015	NON-COMPETING CONTINUATION	$214,285
2015	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	005	5	9/18/2015	SUPPLEMENT FOR EXPANSION	$0
2015	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	003	5	8/27/2015	SUPPLEMENT FOR EXPANSION	-$385,714
2015	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	010	5	9/28/2015	SUPPLEMENT FOR EXPANSION	-$385,714
2015	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	011	5	9/29/2015	SUPPLEMENT FOR EXPANSION	$385,714
2015	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	009	5	9/28/2015	NON-COMPETING CONTINUATION	-$214,285
2015	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	004	5	8/28/2015	SUPPLEMENT FOR EXPANSION	$385,714
2015	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	002	5	7/31/2015	SUPPLEMENT FOR EXPANSION	$499,998
2015	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	013	5	9/29/2015	SUPPLEMENT FOR EXPANSION	$499,998
2015	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	014	5	9/30/2015	SUPPLEMENT FOR EXPANSION	$0
2015	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	006	5	9/23/2015	SUPPLEMENT FOR EXPANSION	-$385,714
2015	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	007	5	9/25/2015	SUPPLEMENT FOR EXPANSION	$385,714
2015	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	000	5	7/28/2015	NON-COMPETING CONTINUATION	$214,285
2015	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	001	5	7/29/2015	SUPPLEMENT FOR EXPANSION	$385,714
2015	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	008	5	9/28/2015	SUPPLEMENT FOR EXPANSION	-$499,998
														Subtotal = $1,099,997

Issue Date FY: 2014 ( Subtotal = $582,820 )
2014	2014	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	000	4	7/10/2014	NON-COMPETING CONTINUATION	$191,291
2014	2014	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	002	4	7/15/2014	NON-COMPETING CONTINUATION	-$191,291
2014	2014	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	001	4	7/14/2014	SUPPLEMENT FOR EXPANSION	$391,529
2014	2014	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	004	4	7/22/2014	NON-COMPETING CONTINUATION	$191,291
2014	2012	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	003	2	7/22/2014	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $582,820

Issue Date FY: 2013 ( Subtotal = $550,000 )
2013	2013	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	000	3	7/31/2013	NON-COMPETING CONTINUATION	$158,471
2013	2013	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	001	3	8/5/2013	SUPPLEMENT FOR EXPANSION	$391,529
														Subtotal = $550,000

Issue Date FY: 2012 ( Subtotal = $526,870 )
2012	2012	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	007	2	7/2/2012	NON-COMPETING CONTINUATION	$59,625
2012	2012	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	006	2	6/20/2012	NON-COMPETING CONTINUATION	$196,242
2012	2012	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	009	2	7/27/2012	SUPPLEMENT FOR EXPANSION	$271,003
2012	2012	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	008	2	7/18/2012	NON-COMPETING CONTINUATION	$0
2012	2011	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	003	1	12/15/2011	SUPPLEMENT FOR EXPANSION	$0
2012	2011	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	004	1	1/26/2012	SUPPLEMENT FOR EXPANSION	$0
2012	2011	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	000	1	11/16/2011	NEW	$0
2012	2011	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	005	1	1/26/2012	NEW	$0
2012	2011	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	002	1	11/29/2011	NEW	$0
2012	2011	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	001	1	11/16/2011	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $526,870

Issue Date FY: 2011 ( Subtotal = $507,245 ) (Continued on the next page)
2011	2011	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	003	1	8/26/2011	SUPPLEMENT FOR EXPANSION	$201,220
2011	2011	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	004	1	9/26/2011	NEW	$0
Grand Total All Awards = $3,191,205

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Enhanced Surveillance for New Vaccine Preventable Diseases

Award Number: U01IP000460

ORGANIZATION: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES(NCIRD)

OPDIV: CDC

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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