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The Intermountain West-Atlantic Center (InterACT) for the APS Phenotyping Consortium

Award Number: U01HL168416
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2023
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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The Intermountain West-Atlantic Center (InterACT) for the APS Phenotyping Consortium - Project Summary This proposal presents the Intermountain West-Atlantic Center (InterACT), which brings together four robust investigative sites to participate in the APS Phenotypes Consortium. InterACT proposes to use robust statistical and machine learning methods to phenotype patients with Acute Respiratory Distress Syndrome (ARDS), pneumonia, and sepsis in two broad proposals. In the first proposal for the entire Consortium, we will use multiplex cytokine arrays and clinical variables in the setting of normalized treatment trajectories to improve the accuracy of phenotyping by accounting for the role treatment plays. This method creates phenotypes that will be confirmed, with an eye toward therapeutic implications, in emulated clinical trials. In the second proposal for the Center specifically, we will focus our statistical methodology on new work investigating the pattern of tissue injury and repair, with a focus on hyaluronan and soluble Receptor for Advanced Glycation Endproducts (sRAGE) as tissue injury biomarkers and predictors of dysregulated inflammation. This work will culminate in emulated trials of novel agents that modulate the pathologic consequences of tissue injury. Together these highly innovative proposals promise actionable, treatment-responsive patient phenotypes for future clinical trials.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $605,111 )
2025	2025	IHC HEALTH SERVICES INC	36 S STATE ST	SALT LAKE CITY	UT	84111	SALT LAKE	USA	Lung Diseases Research	000	3	4/29/2025	NON-COMPETING CONTINUATION	$544,601
2025	2025	IHC HEALTH SERVICES INC	36 S STATE ST	SALT LAKE CITY	UT	84111	SALT LAKE	USA	Lung Diseases Research	001	3	5/30/2025	NON-COMPETING CONTINUATION	$60,510
														Subtotal = $605,111

Issue Date FY: 2024 ( Subtotal = $335,106 )
2024	2024	INTERMOUNTAIN HEALTH CARE, INC.	36 S STATE ST STE 2200	SALT LAKE CITY	UT	84111	SALT LAKE	USA	Lung Diseases Research	000	2	5/9/2024	NON-COMPETING CONTINUATION	$335,106
2024	2024	INTERMOUNTAIN HEALTH CARE, INC.	36 S STATE ST STE 2200	SALT LAKE CITY	UT	84111	SALT LAKE	USA	Lung Diseases Research	001	2	8/22/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $335,106

Issue Date FY: 2023 ( Subtotal = $193,126 )
2023	2023	INTERMOUNTAIN HEALTH CARE, INC.	36 S STATE ST STE 1600	SALT LAKE CITY	UT	84111	SALT LAKE	USA	Lung Diseases Research	000	1	4/25/2023	NEW	$193,126
														Subtotal = $193,126

Grand Total All Awards = $1,133,343

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The Intermountain West-Atlantic Center (InterACT) for the APS Phenotyping Consortium

Award Number: U01HL168416

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2023

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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