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Atlanta MACS/WIHS Combined Cohort Study Clinical Research Site

Award Number: U01HL146241
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2019
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Atlanta MACS/WIHS Combined Cohort Study Clinical Research Site - Abstract The overarching goal of the Atlanta Clinical Research Site (CRS) is to advance the unified scientific agenda of the MACS/WIHS CCS by: a) providing leadership in the development of the unified science protocols; b) serving as a local reading center and support laboratory for studies; and c) leveraging our research infrastructure to implement the CCS protocols by retaining current participants, recruiting new participants from under-represented minority groups, and engaging Emory scientists and the local community in CCS science and activities. The Atlanta CRS is well poised to accomplish these goals because of our unique location at the epicenter of the U.S. epidemic, the robustness of our HIV research program, and our track record of successful and collaborative contribution to the unified science of the WIHS over the past 5 years. Georgia now has the third highest rate of new HIV diagnoses among the Southern states1 and the 5th largest HIV epidemic among the U.S. states2. While HIV rates are high in both rural and urban Georgia, Atlanta is home to most (62%) of the state’s affected patients, and the majority reside within 10 miles of the Atlanta CRS. Importantly, nearly two-thirds of people living with HIV in Atlanta and ~20% in Georgia receive care in Emory associated HIV clinics (n=10,354). HIV+ and negative volunteers that have consented to be contacted for research are available via the CFAR HIV Disease Registry (> 13,000 unique patients), the PRISM Health MSM cohorts led by Emory faculty Dr. Patrick Sullivan, and the Georgia CTSA database (>100,000 individuals), providing us access to a diverse population of HIV+ and at-risk HIV- individuals from across the state. Leveraging these institutional resources, the Atlanta CRS will contribute to the CCS unified science in the following manner: 1) Provide leadership to support the CCS unified specific aims through expert contribution by Emory investigators, including scientific specific leadership roles in the following aims: (a) age related co- morbidities; (b) health disparities; (c) HIV pathogenesis; and (d) career development; 2) Leverage our state-of- the-art research infrastructure to implement all components of the CCS unified science, including adjudication of clinical events, development of data quality control procedures and good laboratory practices, staff training in relevant CCS research activities, and enrollment of new participants; 3) Enhance our vibrant community engagement to support our efforts to enroll new participants, expand our CAB to be representative of the combined cohort of women and men, and introduce use of innovative technology to enhance community outreach and support accrual and engagement of our combined cohort; and 4) Build on our track record of mentorship by expanding HIV research opportunities for early stage investigators in coordination with the CCS Investigator Developmental Award Advisory Committee.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,948,385 )
2025	2025	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	001	7	3/28/2025	NON-COMPETING CONTINUATION	$2,653,547
2025	2025	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	002	7	7/8/2025	NON-COMPETING CONTINUATION	$294,838
2025	2024	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	000	6	12/18/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,948,385

Issue Date FY: 2024 ( Subtotal = $2,995,554 )
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	001	6	5/20/2024	NON-COMPETING CONTINUATION	$2,995,554
2024	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	000	5	3/15/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,995,554

Issue Date FY: 2023 ( Subtotal = $3,034,067 )
2023	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	000	5	4/24/2023	NON-COMPETING CONTINUATION	$3,034,067
														Subtotal = $3,034,067

Issue Date FY: 2022 ( Subtotal = $3,027,878 )
2022	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	001	4	4/22/2022	NON-COMPETING CONTINUATION	$3,027,878
2022	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	000	3	10/21/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $3,027,878

Issue Date FY: 2021 ( Subtotal = $3,075,497 )
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	001	3	3/12/2021	NON-COMPETING CONTINUATION	$3,041,145
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	002	3	8/22/2021	SUPPLEMENT FOR EXPANSION	$34,352
2021	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	000	2	11/24/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,075,497

Issue Date FY: 2020 ( Subtotal = $3,595,174 )
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	008	2	9/10/2020	SUPPLEMENT FOR EXPANSION	$601,354
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	005	2	6/16/2020	SUPPLEMENT FOR EXPANSION	$20,152
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	004	2	5/29/2020	NON-COMPETING CONTINUATION	$0
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	003	2	4/14/2020	NON-COMPETING CONTINUATION	$0
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	007	2	8/25/2020	SUPPLEMENT FOR EXPANSION	$4,325
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	006	2	8/15/2020	SUPPLEMENT FOR EXPANSION	$28,408
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	002	2	3/30/2020	NON-COMPETING CONTINUATION	$2,940,935
2020	2019	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	000	1	11/23/2019	NEW	$0
2020	2019	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	001	1	3/16/2020	NEW	$0
														Subtotal = $3,595,174

Issue Date FY: 2019 ( Subtotal = $2,892,686 )
2019	2019	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	001	1	4/17/2019	NEW	$0
2019	2019	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	000	1	3/29/2019	NEW	$2,435,000
2019	2019	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	003	1	9/16/2019	SUPPLEMENT FOR EXPANSION	$33,799
2019	2019	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Cardiovascular Diseases Research	002	1	9/13/2019	SUPPLEMENT FOR EXPANSION	$423,887
														Subtotal = $2,892,686

Grand Total All Awards = $21,569,241

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Atlanta MACS/WIHS Combined Cohort Study Clinical Research Site

Award Number: U01HL146241

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2019

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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