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MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS)

Award Number: U01HL146202
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2019
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS) - PROJECT SUMMARY This project will establish and implement the Brooklyn Clinical Research Site (Bklyn CRS) of the MACS/WIHS Combined Cohort Study (MACS/WIHS CCS) and support its mission to advance the clinical, behavioral, and epidemiological science of newly diagnosed and chronic HIV infection and associated comorbidities. The Bklyn CRS evolves from and builds upon a 25-year history of scientific innovation accompanied by community engagement that facilitated rigorous implementation of the Brooklyn Women's Interagency HIV Study (WIHS). The Bklyn CRS will rapidly develop a diverse cohort of men and women reflecting the unique characteristics of HIV in our geographic area. We will include continued follow-up of WIHS participants, who contribute a rich longitudinal history of clinical, biologic, genetic, psychosocial and behavioral data derived from midlife and younger ages, informing questions of HIV and aging in an older population. The Bklyn CRS investigators will develop and implement protocols of the MACS/WIHS CCS Unified Science Agenda, contribute to the overall functioning of the administrative infrastructure, and engage a strong and multidisciplinary team of researchers in addressing innovative science. Our specific aims are to: 1) recruit and retain a prospective cohort of 500 men and women living with HIV and matched seronegative controls and implement MACS/WIHS CCS study protocols; 2) engage a multidisciplinary and experienced team of scientists to develop and implement innovative research that aligns with and advances the CCS Unified Science Agenda; and 3) provide training and career development opportunities to support advancement of the next generation of HIV researchers. The Bklyn CRS provides scientific, administrative and collaborative leadership in cardiovascular disease and associated lung and sleep outcomes; aging via physical, functional and molecular assessments; psychological and social environmental aspects of self-management of HIV and associated co-morbidities; and neurocognition and brain aging. As such, the Bklyn CRS will greatly enhance the MACS/WIHS CCS, ensuring the rigor and relevance of study questions and methods to address those questions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,882,001 )
2025	2025	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	001	7	4/11/2025	NON-COMPETING CONTINUATION	$2,593,802
2025	2025	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	002	7	7/8/2025	NON-COMPETING CONTINUATION	$288,199
2025	2024	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	000	6	1/17/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,882,001

Issue Date FY: 2024 ( Subtotal = $2,817,027 )
2024	2024	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	001	6	5/20/2024	NON-COMPETING CONTINUATION	$2,817,027
2024	2023	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	000	5	1/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,817,027

Issue Date FY: 2023 ( Subtotal = $2,813,254 )
2023	2023	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	000	5	4/24/2023	NON-COMPETING CONTINUATION	$2,813,254
														Subtotal = $2,813,254

Issue Date FY: 2022 ( Subtotal = $2,786,708 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	000	4	4/22/2022	NON-COMPETING CONTINUATION	$2,786,708
														Subtotal = $2,786,708

Issue Date FY: 2021 ( Subtotal = $2,818,534 )
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	001	3	3/11/2021	NON-COMPETING CONTINUATION	$2,779,134
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	002	3	8/22/2021	SUPPLEMENT FOR EXPANSION	$39,400
2021	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	000	2	11/24/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,818,534

Issue Date FY: 2020 ( Subtotal = $3,463,351 )
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	006	2	8/15/2020	SUPPLEMENT FOR EXPANSION	$38,636
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	005	2	7/10/2020	SUPPLEMENT FOR EXPANSION	$401,024
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	001	2	3/30/2020	NON-COMPETING CONTINUATION	$2,880,797
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	003	2	5/29/2020	NON-COMPETING CONTINUATION	$0
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	002	2	4/14/2020	NON-COMPETING CONTINUATION	$0
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	007	2	9/10/2020	SUPPLEMENT FOR EXPANSION	$119,066
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	004	2	6/17/2020	SUPPLEMENT FOR EXPANSION	$23,828
2020	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	000	1	3/19/2020	NEW	$0
														Subtotal = $3,463,351

Issue Date FY: 2019 ( Subtotal = $2,778,778 )
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	001	1	4/19/2019	NEW	$0
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	000	1	3/29/2019	NEW	$2,339,271
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	002	1	6/7/2019	NEW	$5,729
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	004	1	9/16/2019	SUPPLEMENT FOR EXPANSION	$25,136
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	450 CLARKSON AVE	BROOKLYN	NY	11203	KINGS	USA	Cardiovascular Diseases Research	003	1	9/12/2019	SUPPLEMENT FOR EXPANSION	$408,642
														Subtotal = $2,778,778

Grand Total All Awards = $20,359,653

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MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS)

Award Number: U01HL146202

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2019

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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