Tuesday, July 1, 2025 7/1/2025

Continuation of the NuMoM2b Heart Health Study

Award Number: U01HL145358
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/15/2020
PERIOD OF PERFORMANCE END DATE: 01/31/2027

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Continuation of the NuMoM2b Heart Health Study - PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in U.S. women at all ages, and large knowledge gaps exist in CVD predictive and preventive strategies for women. The nuMoM2b Heart Health Study (nuMoM2b-HHS) has followed a demographically diverse cohort of 4,475 women enrolled and richly phenotyped during their first pregnancy, with data and biospecimens prospectively collected for up to 7 years thereafter. The overarching scientific goal of the nuMoM2b-HHS is to define the relationship between adverse pregnancy outcomes (APOs) and CVD to optimize CVD prediction, prevention, and treatment strategies for women. Continued follow-up of this cohort, building on a foundation of existing high-quality data, biospecimens, and administrative structures with a robust framework for ancillary study development and implementation, provides a unique opportunity to address knowledge gaps regarding the early mechanisms and trajectory of CVD in women. We propose to continue nuMoM2b-HHS follow-up through semiannual contacts and an in-person visit to assess CVD risk factors during grant years 3-5 (Aim 1). Accumulated longitudinal data and biospecimens will serve as a broadly accessible platform for ancillary studies to identify early mechanisms of CVD and to address additional NIH priority domains including early manifestations of cerebrovascular and renal disease in reproductive-age women. Ancillary studies (Aim 2) will expand data collection during the follow-up contacts and in-person visit, and add to the planned contact schedule, to permit the effective targeting of knowledge gaps required to optimize predictive and preventive strategies. The Specific Aims reflect a multifaceted approach to the study of the incidence and mechanisms of CVD development in women of reproductive age, focusing on the incidence of CVD risk factors in women with and without APOs (Aim 3); the associations between atherogenic phenotypes and sleep-disordered breathing during and after pregnancy and estimated CVD risk 6-15 years later (Aims 4 and 5, respectively); and identification of modifiable factors that influence or moderate these associations (Aim 6). This application has several strengths that reflect the potential for long-term success of the cohort: (1) The nuMoM2b-HHS will be led by three deeply experienced PIs with complementary domains of expertise in cardiology, maternal-fetal medicine, and biostatistics. (2) The network has robust infrastructure in place to maintain long-term participant engagement and support rigorous data collection. (3) The cohort's high-quality data and biospecimens have been collected under regulatory frameworks that support resource sharing and use in future research. (4) The network has established processes for successfully proposing, reviewing, and implementing ancillary studies. This foundation of strong leadership, robust administrative and operational infrastructure, and actualized long-term vision will provide an ideal environment for the nuMoM2b-HHS to continue to address critical knowledge gaps concerning CVD development in women of reproductive age.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,480,433 )
2025	2025	RESEARCH TRIANGLE INSTITUTE	3040 CORNWALLIS RD	DURHAM	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	000	6	12/11/2024	NON-COMPETING CONTINUATION	$2,480,433
2025	2024	RESEARCH TRIANGLE INSTITUTE	3040 CORNWALLIS RD	DURHAM	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	002	5	2/28/2025	NON-COMPETING CONTINUATION	$0
2025	2023	RESEARCH TRIANGLE INSTITUTE	3040 CORNWALLIS RD	DURHAM	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	001	4	2/26/2025	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,480,433

Issue Date FY: 2024 ( Subtotal = $2,809,155 )
2024	2024	RESEARCH TRIANGLE INSTITUTE	3040 CORNWALLIS RD	DURHAM	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	002	5	6/12/2024	NON-COMPETING CONTINUATION	$229,319
2024	2024	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	000	5	12/26/2023	NON-COMPETING CONTINUATION	$2,579,836
2024	2023	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	001	4	2/2/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,809,155

Issue Date FY: 2023 ( Subtotal = $4,971,541 )
2023	2023	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	003	4	8/21/2023	SUPPLEMENT FOR EXPANSION	$2,129,960
2023	2023	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	001	4	12/25/2022	NON-COMPETING CONTINUATION	$2,841,581
2023	2022	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	002	3	8/10/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2022	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	000	3	12/16/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,971,541

Issue Date FY: 2022 ( Subtotal = $3,197,941 )
2022	2022	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	006	3	9/9/2022	SUPPLEMENT FOR EXPANSION	$99,999
2022	2022	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	005	3	8/17/2022	SUPPLEMENT FOR EXPANSION	$15,811
2022	2022	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	002	3	2/2/2022	NON-COMPETING CONTINUATION	$0
2022	2022	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	004	3	8/2/2022	SUPPLEMENT FOR EXPANSION	$281,696
2022	2022	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	003	3	6/8/2022	NON-COMPETING CONTINUATION	$280,048
2022	2022	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	000	3	1/26/2022	NON-COMPETING CONTINUATION	$2,520,387
2022	2021	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	001	2	2/1/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,197,941

Issue Date FY: 2021 ( Subtotal = $3,167,867 )
2021	2021	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	003	2	6/27/2021	SUPPLEMENT FOR EXPANSION	$219,657
2021	2021	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	002	2	5/25/2021	NON-COMPETING CONTINUATION	$255,077
2021	2021	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	001	2	4/9/2021	SUPPLEMENT FOR EXPANSION	$397,456
2021	2021	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	000	2	2/2/2021	NON-COMPETING CONTINUATION	$2,295,677
														Subtotal = $3,167,867

Issue Date FY: 2020 ( Subtotal = $4,884,312 )
2020	2020	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	002	1	8/18/2020	SUPPLEMENT FOR EXPANSION	$99,962
2020	2020	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	004	1	8/21/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	003	1	8/19/2020	SUPPLEMENT FOR EXPANSION	$2,389,614
2020	2020	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	000	1	2/12/2020	NEW	$2,394,736
2020	2020	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	001	1	6/6/2020	NEW	$0
2020	2020	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cardiovascular Diseases Research	005	1	8/21/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $4,884,312

Grand Total All Awards = $21,511,249

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Continuation of the NuMoM2b Heart Health Study

Award Number: U01HL145358

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/15/2020

PERIOD OF PERFORMANCE END DATE: 01/31/2027

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