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THE FAMILY BLOOD PRESSURE PROGRAM (SAPPHIRE NETWORK)

Award Number: U01HL054498
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/05/1995
PERIOD OF PERFORMANCE END DATE: 08/31/2011

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THE FAMILY BLOOD PRESSURE PROGRAM (SAPPHIRE NETWORK) - DESCRIPTION (provided by applicant): The Family Blood Pressure Program [FBPP] is an unprecedented collaboration to identify genes influencing blood pressure levels, hypertension and its cardiovascular complications (hereafter referred to as "hypertension genes"). To date, the Program has carried out 21,600 physical examinations, assembled a shared database of 294 hypertension-relevant variables, measured quantitative echocardiograms on 7,321 individuals, carried-out genome-wide linkage analyses for hypertension status and 13 related phenotypes, published (or in press) 128 manuscripts and identified 5 hypertension susceptibility genes by following-up 4 linkage peaks. In the proposed next phase of the FBPP, a major emphasis is placed on making the Program a shared resource for hypertension researchers in the United States and throughout the world. In Aim 1, we will build, maintain and update a publicly available knowledge-base to facilitate research by non-FBPP investigators on the genetics of hypertension, its risk factors and its complications. In Aim 2, we will use state-of-the-art genetic linkage analysis methods to identify additional linkage regions using subgroups of pedigrees and physiologically relevant combinations of phenotypes that will aid in localizing hypertension genes. In Aim 3, we will use a combination of bioinformatics, a dense array of SNPs, and state-of-the-art data analysis to follow-up regions of interest and identify the underlying hypertension genes. The regions to be followed-up include those identified during the current phase of the FBPP and Aim 2 of this renewal phase. In Aim 4, we will evaluate the hypertension genes identified in Aim 3 for their association with multiple measures reflecting the cardiovascular and renal complications of hypertension, including left ventricular mass and microalbuminuria. It is the long-term goal of the FBPP to have the hypertension genetics community develop a comprehensive picture of the genetic architecture of human hypertension, including its risk factors, complications, and response to treatment. (End of Abstract)


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2007	KUAKINI MEDICAL CENTER	347 N KUAKINI STREET	HONOLULU	HI	96817	HONOLULU	USA	Cardiovascular Diseases Research	002	14	5/27/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$107,380
2010	2007	PACIFIC HEALTH RESEARCH INSTITUTE	846 SOUTH HOTEL STREET	HONOLULU	HI	96813	HONOLULU	USA	Cardiovascular Diseases Research	000	13	3/31/2010	NON-COMPETING CONTINUATION	$0
2010	2007	PACIFIC HEALTH RESEARCH INSTITUTE	846 SOUTH HOTEL STREET	HONOLULU	HI	96813	HONOLULU	USA	Cardiovascular Diseases Research	001	13	5/24/2010	NON-COMPETING CONTINUATION	-$107,380
														Subtotal = $0

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2007	PACIFIC HEALTH RESEARCH INSTITUTE	846 SOUTH HOTEL STREET	HONOLULU	HI	96813	HONOLULU	USA	Cardiovascular Diseases Research	000	13	8/13/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2007 ( Subtotal = $516,908 )
2007	2007	PACIFIC HEALTH RESEARCH INSTITUTE	846 SOUTH HOTEL STREET	HONOLULU	HI	96813	HONOLULU	USA	Cardiovascular Diseases Research	000	13	8/3/2007	NON-COMPETING CONTINUATION	$516,908
														Subtotal = $516,908

Issue Date FY: 2006 ( Subtotal = $543,062 )
2006	2006	PACIFIC HEALTH RESEARCH INSTITUTE	846 SOUTH HOTEL STREET	HONOLULU	HI	96813	HONOLULU	USA	Cardiovascular Diseases Research	001	11	4/28/2006	SUPPLEMENT FOR EXPANSION	$5,500
2006	2006	PACIFIC HEALTH RESEARCH INSTITUTE	846 SOUTH HOTEL STREET	HONOLULU	HI	96813	HONOLULU	USA	Cardiovascular Diseases Research	000	12	8/31/2006	NON-COMPETING CONTINUATION	$537,562
														Subtotal = $543,062

Issue Date FY: 2004 ( Subtotal = $582,357 )
2004	2004	PACIFIC HEALTH RESEARCH INSTITUTE	846 SOUTH HOTEL STREET	HONOLULU	HI	96813	HONOLULU	USA	Cardiovascular Diseases Research	000	10	7/7/2004	NON-COMPETING CONTINUATION	$582,357
														Subtotal = $582,357

Issue Date FY: 2003 ( Subtotal = $815,954 )
2003	2003	PACIFIC HEALTH RESEARCH INSTITUTE	846 SOUTH HOTEL STREET	HONOLULU	HI	96813	HONOLULU	USA	Cardiovascular Diseases Research	000	9	7/15/2003	NON-COMPETING CONTINUATION	$815,954
														Subtotal = $815,954

Issue Date FY: 2002 ( Subtotal = $903,262 )
2002	2002	PACIFIC HEALTH RESEARCH INSTITUTE	846 SOUTH HOTEL STREET	HONOLULU	HI	96813	HONOLULU	USA	Cardiovascular Diseases Research	000	8	7/15/2002	NON-COMPETING CONTINUATION	$903,262
														Subtotal = $903,262

Issue Date FY: 2001 ( Subtotal = $1,149,542 )
2001	2001	PACIFIC HEALTH RESEARCH INSTITUTE	846 SOUTH HOTEL STREET	HONOLULU	HI	96813	HONOLULU	USA	Cardiovascular Diseases Research	000	7	9/26/2001	NON-COMPETING CONTINUATION	$1,149,542
														Subtotal = $1,149,542

Issue Date FY: 2000 ( Subtotal = $434,331 )
2000	2000	PACIFIC HEALTH RESEARCH INSTITUTE	846 SOUTH HOTEL STREET	HONOLULU	HI	96813	HONOLULU	USA	Cardiovascular Diseases Research	000	6	9/25/2000	COMPETING CONTINUATION	$434,331
														Subtotal = $434,331

Issue Date FY: 1999 ( Subtotal = $142,984 )
1999	1999	UNIVERSITY OF HAWAII	2530 Dole St., Sakamaki D200	HONOLULU	HI	96822	HONOLULU	USA	Cardiovascular Diseases Research	000	5	9/6/1999	NON-COMPETING CONTINUATION	$142,984
														Subtotal = $142,984

Issue Date FY: 1998 ( Subtotal = $266,744 )
1998	1998	UNIVERSITY OF HAWAII	2530 Dole St., Sakamaki D200	HONOLULU	HI	96822	HONOLULU	USA	Cardiovascular Diseases Research	000	4	9/14/1998	NON-COMPETING CONTINUATION	$266,744
														Subtotal = $266,744

Grand Total All Awards = $5,355,144

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THE FAMILY BLOOD PRESSURE PROGRAM (SAPPHIRE NETWORK)

Award Number: U01HL054498

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/05/1995

PERIOD OF PERFORMANCE END DATE: 08/31/2011

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