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CARDIOVASCULAR DISEASE IN SIOUX INDIANS

Award Number: U01HL041652
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/1988
PERIOD OF PERFORMANCE END DATE: 03/31/2013

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CARDIOVASCULAR DISEASE IN SIOUX INDIANS - DESCRIPTION (provided by applicant): There is an epidemic of cardiovascular disease (CVD) among American Indians. The Strong Heart Study (SHS) has been examining CVD and its risk factors by conducting a longitudinal cohort study and a family genetic study among 13 communities in 3 geographic areas (Arizona, the Dakotas, and Oklahoma). This application proposes to extend the SHS to pursue the following aims: 1) Expand the genetic studies that will emphasize the genome scan approach, but also include investigation of carefully selected candidate genes. The completed genome scan of 3776 members from 94 extended families will be used to identify quantitative trait loci and narrow the regions of interest by fine mapping. We also will examine a selected number of candidate genes that are difficult to exclude on the basis of linkage studies, but are of potential importance to vascular disease. 2) Continue the mortality and morbidity surveillance of the original cohort (approximately2859 male and female survivors, ages 60-89 years) and to initiate annual mortality surveillance and limited morbidity follow-up of the non-cohort family members. 3) Re-examine the family members so that changes in risk factors can be analyzed and genetic effects on changes estimated. Advantages of the SHS include: 1) It provides health data on an underserved ethnic group, 2) It is the largest, longest longitudinal study in the US of CVD and its risk factors in individuals with diabetes, 3) Data from cardiac, carotid, and popliteal ultrasound measures will substantially improve understanding of mechanisms of vascular disease in diabetes and the genetics of CVD, 4) This population includes a group in which the epidemic of obesity and diabetes has impacted people at very young ages, permitting analysis of genetic and environmental effects on these conditions with limited confounding by age effects. SHS will lead to valuable therapeutic and prevention strategies for this and other populations in the US and the world, where the epidemics of obesity, diabetes and CVD are progressing rapidly. The relevance of this research to public health: The SHS studies diseases of the heart and blood vessels in American Indian Communities, in order to try to explain the rapid increases that have been recently observed. The study is attempting to learn about predictors of disease, and to see to what extend it runs in families. SHS is valuable because it provides information on how diabetes leads to diseases of the heart and blood vessels that will be useful in many populations who now have high rates of diabetes. (End of Abstract)


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $19,512 )
2013	2013	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	001	21	2/1/2013	SUPPLEMENT FOR EXPANSION	$19,512
2013	2010	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	000	21	1/31/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $19,512

Issue Date FY: 2012 ( Subtotal = $0 )
2012	2010	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	000	21	1/16/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $300,000 )
2011	2011	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	001	21	4/8/2011	SUPPLEMENT FOR EXPANSION	$300,000
2011	2010	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	000	21	3/28/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $300,000

Issue Date FY: 2010 ( Subtotal = $313,229 )
2010	2010	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	000	21	3/18/2010	NON-COMPETING CONTINUATION	$313,229
														Subtotal = $313,229

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2008	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	000	20	5/29/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2008 ( Subtotal = $935,139 )
2008	2008	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	000	20	7/3/2008	NON-COMPETING CONTINUATION	$935,139
														Subtotal = $935,139

Issue Date FY: 2007 ( Subtotal = $1,074,734 )
2007	2007	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	000	19	3/30/2007	NON-COMPETING CONTINUATION	$1,074,734
														Subtotal = $1,074,734

Issue Date FY: 2006 ( Subtotal = $1,122,325 )
2006	2006	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	000	18	4/25/2006	COMPETING CONTINUATION	$1,122,325
														Subtotal = $1,122,325

Issue Date FY: 2004 ( Subtotal = $254,321 )
2004	2004	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	000	17	7/28/2004	NON-COMPETING CONTINUATION	$254,321
														Subtotal = $254,321

Issue Date FY: 2003 ( Subtotal = $274,256 )
2003	2003	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	000	16	9/12/2003	NON-COMPETING CONTINUATION	$274,256
														Subtotal = $274,256

Issue Date FY: 2002 ( Subtotal = $950,500 )
2002	2002	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	000	15	9/27/2002	NON-COMPETING CONTINUATION	$950,500
														Subtotal = $950,500

Issue Date FY: 2001 ( Subtotal = $1,008,000 )
2001	2001	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	000	14	5/29/2001	NON-COMPETING CONTINUATION	$1,008,000
														Subtotal = $1,008,000

Issue Date FY: 2000 ( Subtotal = $964,014 )
2000	2000	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	000	13	8/10/2000	COMPETING CONTINUATION	$964,014
														Subtotal = $964,014

Issue Date FY: 1999 ( Subtotal = $370,182 )
1999	1999	Great Plains Tribal Chairmen`s Health Board	2611 Elderberry Blvd	RAPID CITY	SD	57703	PENNINGTON	USA	Cardiovascular Diseases Research	000	12	6/30/1999	NON-COMPETING CONTINUATION	$370,182
														Subtotal = $370,182

Issue Date FY: 1998 ( Subtotal = $733,865 )
1998	1998	Great Plains Tribal Chairmen`s Health Board	2611 Elderberry Blvd	RAPID CITY	SD	57703	PENNINGTON	USA	Cardiovascular Diseases Research	000	11	6/17/1998	NON-COMPETING CONTINUATION	$700,265
1998	1998	Great Plains Tribal Chairmen`s Health Board	2611 Elderberry Blvd	RAPID CITY	SD	57703	PENNINGTON	USA	Cardiovascular Diseases Research	001	10	2/27/1998	SUPPLEMENT FOR EXPANSION	$33,600
														Subtotal = $733,865

Grand Total All Awards = $8,320,077

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CARDIOVASCULAR DISEASE IN SIOUX INDIANS

Award Number: U01HL041652

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/1988

PERIOD OF PERFORMANCE END DATE: 03/31/2013

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