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Computational Tools for Population-Scale Assembly and Genotyping with Pangenomes

Award Number: U01HG014892
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/11/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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Computational Tools for Population-Scale Assembly and Genotyping with Pangenomes - Project Summary Capturing the full allelic diversity in highly variable regions of the human genome requires large- scale sequencing efforts, yet current approaches face signiﬁcant cost and privacy-related chal- lenges. The Human Pangenome Reference Consortium (HPRC) aims to expand its pangenome reference to 350 individuals by 2025, but scaling further remains difﬁcult due to the high cost of long-read sequencing and barriers to data sharing across institutions. To address these challenges, our proposal brings together experts in genome assembly, genotyping, and privacy technologies to develop scalable and privacy-preserving methods for pangenome construction and analysis. Our speciﬁc aims include: developing co-assembly pipelines that leverage shared genetic variation to enable cost-efﬁcient pangenome assembly from low-coverage sequencing data (Aim 1), creating privacy-preserving tools for utilizing pangenomes together with private or controlled-access data (Aim 2), and building production-grade software and resources to facilitate adoption of our tools by the genomics community (Aim 3). By enabling efﬁcient, secure, and scalable pangenome con- struction, our work aims to accelerate population-scale pangenomics research and improve analysis of complex, multiallelic regions of the human genome.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,967,182 )
2026	2026	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Human Genome Research	000	1	5/14/2026	NEW	$1,967,182
														Subtotal = $1,967,182

Grand Total All Awards = $1,967,182

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Computational Tools for Population-Scale Assembly and Genotyping with Pangenomes

Award Number: U01HG014892

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/11/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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