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eMERGE IV Northwest: A partnership to evaluate the use of genomic information in health care

Award Number: U01HG008657
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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eMERGE IV Northwest: A partnership to evaluate the use of genomic information in health care - Project Abstract This eMERGE IV (E4) supplement proposes extend the outcomes timeline for the prior implementation of 10 “genomic risk assessment” (GIRA) scores in a network-wide set of participants. These GIRAs include polygenic risk score (PRS) information, as well as risk information, such as personal and family health history, environmental and social health determinants, and physical and lab measures. Substantial challenges must be addressed before genomic medicine is a part of standard medical care. The specific aims of our proposal are designed to use an implementation science approach to advance the integration of genomic data into clinical practice, including evaluation of patient perspectives and economic outcomes, and broadening the impact of eMERGE through collaborations. The University of Washington Medicine dedication to preventative health in a learning health system and broad expertise across genomics, statistical, ethical, informatic, implementation, outcomes and economic disciplines will support this multi-site clinical trial. We will continue our leadership in data- cleaning and in the analyses of outcomes data. Specific Aims: Aim 1: Extend capture clinical outcomes for 10 GIRA on existing participants. Aim 2: Evaluate the implementation, effectiveness, and economic utility of GIRA result return to identify opportunities to improve human health for common disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $828,982 )
2026	2026	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	001	10	5/8/2026	SUPPLEMENT FOR EXPANSION	$828,982
2026	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	002	10	5/19/2026	SUPPLEMENT FOR EXPANSION	$0
2026	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	000	10	5/7/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $828,982

Issue Date FY: 2025 ( Subtotal = $802,277 )
2025	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	001	10	7/28/2025	SUPPLEMENT FOR EXPANSION	$802,277
2025	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	000	10	7/28/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $802,277

Issue Date FY: 2024 ( Subtotal = $828,364 )
2024	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	002	10	5/29/2024	NON-COMPETING CONTINUATION	$67,622
2024	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	001	10	5/8/2024	NON-COMPETING CONTINUATION	$760,742
2024	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	000	9	11/17/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $828,364

Issue Date FY: 2023 ( Subtotal = $1,298,336 )
2023	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	000	9	6/1/2023	NON-COMPETING CONTINUATION	$1,298,336
														Subtotal = $1,298,336

Issue Date FY: 2022 ( Subtotal = $1,548,501 )
2022	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	004	8	7/8/2022	NON-COMPETING CONTINUATION	$1,548,501
2022	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	003	7	7/7/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	002	7	11/10/2021	NON-COMPETING CONTINUATION	$0
2022	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	001	6	10/29/2021	COMPETING CONTINUATION	$106,796
2022	2019	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Human Genome Research	000	5	10/29/2021	SUPPLEMENT FOR EXPANSION	-$106,796
														Subtotal = $1,548,501

Issue Date FY: 2021 ( Subtotal = $1,682,350 )
2021	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	007	7	7/8/2021	NON-COMPETING CONTINUATION	$1,682,350
2021	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	003	6	11/12/2020	COMPETING CONTINUATION	$106,295
2021	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	006	6	6/15/2021	COMPETING CONTINUATION	-$106,295
2021	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	004	6	3/26/2021	COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	000	6	10/19/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2019	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Human Genome Research	002	5	11/12/2020	SUPPLEMENT FOR EXPANSION	-$106,295
2021	2019	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Human Genome Research	001	5	10/28/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2019	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Human Genome Research	005	5	6/15/2021	SUPPLEMENT FOR EXPANSION	$106,295
														Subtotal = $1,682,350

Issue Date FY: 2020 ( Subtotal = $1,721,443 )
2020	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	003	6	9/16/2020	SUPPLEMENT FOR EXPANSION	$375,152
2020	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Human Genome Research	002	6	7/1/2020	COMPETING CONTINUATION	$1,346,291
2020	2018	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Human Genome Research	000	5	3/12/2020	NON-COMPETING CONTINUATION	$0
2020	2018	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Human Genome Research	001	5	6/30/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,721,443

Issue Date FY: 2019 ( Subtotal = $707,923 )
2019	2019	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Human Genome Research	002	5	4/25/2019	SUPPLEMENT FOR EXPANSION	$707,923
2019	2018	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Human Genome Research	003	5	5/20/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Human Genome Research	001	5	4/24/2019	NON-COMPETING CONTINUATION	$0
2019	2018	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Human Genome Research	000	5	12/18/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $707,923

Issue Date FY: 2018 ( Subtotal = $1,116,543 )
2018	2018	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Human Genome Research	003	5	6/1/2018	NON-COMPETING CONTINUATION	$840,228
2018	2018	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Human Genome Research	004	5	8/29/2018	SUPPLEMENT FOR EXPANSION	$276,315
2018	2017	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Human Genome Research	002	4	2/9/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$303,639
2018	2016	KAISER FOUNDATION HEALTH PLAN OF WASHINGTON	601 UNION ST STE 3100	SEATTLE	WA	98101	KING	USA	Human Genome Research	001	2	2/9/2018	SUPPLEMENT FOR EXPANSION	-$72,000
2018	2016	KAISER FOUNDATION HEALTH PLAN OF WASHINGTON	601 UNION ST STE 3100	SEATTLE	WA	98101	KING	USA	Human Genome Research	000	2	2/9/2018	NON-COMPETING CONTINUATION	-$231,639
														Subtotal = $1,116,543

Issue Date FY: 2017 ( Subtotal = $896,954 )
2017	2017	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Human Genome Research	002	4	9/13/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$842,722
2017	2017	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Human Genome Research	003	4	9/15/2017	SUPPLEMENT FOR EXPANSION	$54,232
2017	2017	KAISER FOUNDATION HEALTH PLAN OF WASHINGTON	320 WESTLAKE AVE N STE 100	SEATTLE	WA	98109	KING	USA	Human Genome Research	000	3	5/26/2017	NON-COMPETING CONTINUATION	$842,722
2017	2017	KAISER FOUNDATION HEALTH PLAN OF WASHINGTON	600 UNIVERSITY ST STE 3100	SEATTLE	WA	98101	KING	USA	Human Genome Research	001	3	9/12/2017	NON-COMPETING CONTINUATION	-$842,722
														Subtotal = $896,954

Issue Date FY: 2016 ( Subtotal = $1,068,374 ) (Continued on the next page)
Grand Total All Awards = $13,359,846

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eMERGE IV Northwest: A partnership to evaluate the use of genomic information in health care

Award Number: U01HG008657

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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