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IRIS: Incorporating Research Into Sight

Award Number: U01HG006389
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2011
PERIOD OF PERFORMANCE END DATE: 07/31/2016

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IRIS: Incorporating Research Into Sight - DESCRIPTION (provided by applicant): The primary goals of this project are first to develop and validate electronic algorithms, to accurately identify cases and controls for each ophthalmic phenotype, and to conduct genome wide association studies that advance our understanding of these disease states and their treatment. The next goal will be to translate clinically meaningful results into clinical practice. The Marshfield Clinic is an ideal setting for translational research, in part because an internally-developed electronic health record facilitates timely incorporation of research results with necessary decision support tools for health care providers. Specific aims include: 1. Develop and validate electronic algorithms for ophthalmic conditions and efficacy of medical therapy for ophthalmic conditions and implement other phenotype algorithms developed across the eMERGE network. Aim 1 a. Develop and validate electronic algorithms for ocular hypertension/glaucoma, intraocular pressure (lOP) response to lOP lowering medications, AMD, response to AMD treatment, tear film insufficiency, response to artificial tears used to treat tear film insufficiency Aim lb. Implement electronic algorithms for phenotypes developed at the other eMERGE sites and share data with the other sites. 2. Leverage GWAS data available for nearly 5000 research subjects aged 50 years and older in Marshfield and an additional 20-25,000 subjects throughout the eMERGE network to undertake genetic discoveries for ophthalmic conditions and ophthalmic pharmacogenetics. Statistical analyses will include traditional GWAS using the SNP data, analysis of copy number variant (CNV) data, and gene/environment analyses. 3. Undertake consultation activities with the general community and clinicians related to the incorporation of GWAS results into electronic health records to inform health care decisions. Aim 3a. Conduct focus group discussion with ophthalmologists related to genetic-based prescribing Aim 3b. Meet with the PMRP Community Advisory Group to discuss potential reconsent of study subjects to allow the sharing of genetic data Aim 3c. Communicate with the entire PMRP cohort about return of results and study progress Aim 3d. Contact all subjects with GWAS data to obtain consent to share their GWAS data with themselves and/or their health care providers, based on the results of the consultation efforts Aim 3e. Incorporate clinically relevant GWAS data in the EMRs for ophthalmologists and optometrists RELEVANCE: With the ageing of the population, vision disorders are becoming more common, impacting quality of life and health care costs. The proposed project will identify gene/environment predictors of glaucoma/ocular hypertension (the second leading cause of blindness), age-related macular degeneration (the leading cause of blindness in the elderly) and dry eye, as well as genetic predictors of response to medical therapy for these conditions. Use of clinically meaningful GWAS data could save sight and health care costs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$101,688 )
2017	2014	ESSENTIA INSTITUTE OF RURAL HEALTH	502 E 2ND ST	DULUTH	MN	55805	SAINT LOUIS	USA	Human Genome Research	000	4	12/6/2016	NON-COMPETING CONTINUATION	-$101,688
														Subtotal = -$101,688

Issue Date FY: 2014 ( Subtotal = $965,749 )
2014	2014	ESSENTIA INSTITUTE OF RURAL HEALTH	502 EAST SECOND STREET	DULUTH	MN	55805	SAINT LOUIS	USA	Human Genome Research	000	4	8/27/2014	NON-COMPETING CONTINUATION	$965,749
														Subtotal = $965,749

Issue Date FY: 2013 ( Subtotal = $1,081,019 )
2013	2013	ESSENTIA INSTITUTE OF RURAL HEALTH	502 EAST SECOND STREET	DULUTH	MN	55805	SAINT LOUIS	USA	Trans-NIH Research Support	001	3	9/13/2013	SUPPLEMENT FOR EXPANSION	$199,894
2013	2013	ESSENTIA INSTITUTE OF RURAL HEALTH	502 EAST SECOND STREET	DULUTH	MN	55805	SAINT LOUIS	USA	Human Genome Research	000	3	9/6/2013	NON-COMPETING CONTINUATION	$881,125
														Subtotal = $1,081,019

Issue Date FY: 2012 ( Subtotal = $1,145,982 )
2012	2012	ESSENTIA INSTITUTE OF RURAL HEALTH	502 EAST SECOND STREET	DULUTH	MN	55805	SAINT LOUIS	USA	Human Genome Research	001	2	9/24/2012	SUPPLEMENT FOR EXPANSION	$408,935
2012	2012	ESSENTIA INSTITUTE OF RURAL HEALTH	502 EAST SECOND STREET	DULUTH	MN	55805	SAINT LOUIS	USA	Human Genome Research	000	2	9/21/2012	NON-COMPETING CONTINUATION	$737,047
														Subtotal = $1,145,982

Issue Date FY: 2011 ( Subtotal = $924,654 )
2011	2011	ESSENTIA INSTITUTE OF RURAL HEALTH	502 EAST SECOND STREET	DULUTH	MN	55805	SAINT LOUIS	USA	Human Genome Research	000	1	8/12/2011	NEW	$773,155
2011	2011	ESSENTIA INSTITUTE OF RURAL HEALTH	502 EAST SECOND STREET	DULUTH	MN	55805	SAINT LOUIS	USA	Human Genome Research	001	1	9/21/2011	SUPPLEMENT FOR EXPANSION	$151,499
														Subtotal = $924,654

Grand Total All Awards = $4,015,716

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IRIS: Incorporating Research Into Sight

Award Number: U01HG006389

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2011

PERIOD OF PERFORMANCE END DATE: 07/31/2016

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