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Structure and function of the placenta from implantation to delivery: a next generation MRI approach

Award Number: U01HD087202
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/17/2015
PERIOD OF PERFORMANCE END DATE: 08/31/2021

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Structure and function of the placenta from implantation to delivery: a next generation MRI approach - ¿ DESCRIPTION (provided by applicant):The long term objective of this project is to develop four MR methodologies to assess placental structure, microstructure and function across gestation, to integrate these into one comprehensive MR examination that is acceptable to pregnant women and to combine this with continuous fetal ECG recordings to provide a step change in antenatal assessment of the normal and abnormally developing placenta when compared to current methods such as those based on ultrasound, velocimetry and serum markers. Specific aims are: To implement and optimize the following techniques: discriminant microstructure assessment based on diffusion imaging, MR elastography and MR susceptibility and hyperoxia for placental imaging so that each is capable of providing sensitive and reliable information. To accelerate these individual methods within a motion correction framework to produce a single robust integrated MR examination that takes no longer than 60 minutes' scanning time. To use this approach to identify differences in placental structure and function across gestation; between normal pregnancies and those at high risk of obstetric syndromes, considered to be secondary to inadequate placental implantation, fetal growth restriction and preeclampsia; and in women with a high BMI >30kg/mm2. To combine highly detailed MRI examination of the placenta with an indirect measure of placental function provided by assessment of fetal heart rate variability. The latter can be determined using overnight continuous fetal ECG, which can be obtained more frequently during progression of an at-risk pregnancy and so provide a comprehensive assessment capability. To validate our approach against placental histology and pregnancy outcomes. The project will deliver a new capability to assess and monitor the placenta in at-risk pregnancies. As obesity rates continue to rise, there will be an increasing burden of such pregnancies and an increasing benefit to society from managing these pregnancies more effectively based on more robust, detailed and comprehensive information.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$182,900 )
2022	2015	KING'S COLLEGE LONDON	THE STRAND	LONDON				GBR	Child Health and Human Development Extramural Research	001	1	10/1/2021	NEW	-$180,325
2022	2015	KING'S COLLEGE LONDON	THE STRAND	LONDON				GBR	Child Health and Human Development Extramural Research	000	1	10/1/2021	NEW	-$2,574
														Subtotal = -$182,900

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2015	KING'S COLLEGE LONDON	THE STRAND	LONDON				GBR	Child Health and Human Development Extramural Research	000	1	11/3/2020	NEW	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2015	KING'S COLLEGE LONDON	THE STRAND	LONDON		WC2R 2LS		GBR	Child Health and Human Development Extramural Research	000	1	8/9/2019	NEW	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	KING'S COLLEGE LONDON	THE STRAND	LONDON		WC2R 2LS		GBR	Child Health and Human Development Extramural Research	001	1	4/13/2017	NEW	$3,229,581
2017	2015	KING'S COLLEGE LONDON	THE STRAND	LONDON		WC2R 2LS		GBR	Child Health and Human Development Extramural Research	000	1	4/12/2017	NEW	-$3,229,581
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $3,229,581 )
2015	2015	QUEEN MARY UNIVERSITY OF LONDON	MILE END ROAD	LONDON				GBR	Child Health and Human Development Extramural Research	000	1	9/17/2015	NEW	$3,229,581
														Subtotal = $3,229,581

Grand Total All Awards = $3,046,681

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Structure and function of the placenta from implantation to delivery: a next generation MRI approach

Award Number: U01HD087202

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/17/2015

PERIOD OF PERFORMANCE END DATE: 08/31/2021

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