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Environmental factors in placental pathology: a new diagnostic method based on umbilical vessel wave mechanics

Award Number: U01HD087177
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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¿ DESCRIPTION (provided by applicant): The placenta grows and adapts during pregnancy to meet the demands of the developing fetus and to respond to changing conditions of the maternal environment. One of the most common causes of pregnancy complications is for the blood vessels within the placenta to develop in an abnormal arrangement, reducing the oxygen and nutrients transferred from the mother to the fetus. Diagnostic ultrasound is the current gold standard for detecting placental problems during pregnancy. Abnormally pulsatile flow in the umbilical cord arteries is an indicator that the downstream vessels are improperly formed. Unfortunately, this approach for detecting placental abnormalities is not always accurate, particularly when abnormalities arise late in gestation. We propose to develop a new method for obtaining more accurate diagnostic information from ultrasound data based on the timing of pressure and blood flow changes within the umbilical cord blood vessels. We will validate this technology using experimental mice that mimic common and severe pregnancy complications. We will also translate the non-invasive method to evaluate human pregnancies. For this, we will conduct a study of pregnant women who are referred for ultrasound either as part of routine screening or because they have been identified as at risk of pregnancy complications. With these data, we will develop criteria for detecting abnormal placental blood flow and compare these with established ultrasound criteria as well as with pathology assessment at birth. The widespread use and availability of ultrasound provides a clear path for clinical translation of the developed technology. Thus, the proposed studies could significantly enhance women's and fetal health through better management of healthy and at-risk pregnancies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2015	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON			CAN	Child Health and Human Development Extramural Research	000	1	11/1/2020	NEW	$0


Issue Date FY: 2019 ( Subtotal = $0 )
2019	2015	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON	M5G 1X8		CAN	Child Health and Human Development Extramural Research	000	1	8/16/2019	NEW	$0


Issue Date FY: 2015 ( Subtotal = $2,507,213 )
2015	2015	HOSPITAL FOR SICK CHILDREN, TORONTO	555 UNIVERSITY AVENUE	TORONTO, ONTARIO				CAN	Child Health and Human Development Extramural Research	000	1	9/17/2015	NEW	$2,507,213


Grand Total All Awards = $2,507,213

Sum of Action Amount is $2,507,213;

Grand Total = $2,507,213

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Environmental factors in placental pathology: a new diagnostic method based on umbilical vessel wave mechanics

Award Number: U01HD087177

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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