Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

IRON AND MALARIA: THE CENTRAL ROLE OF HEPCIDEN AND MACAROPHAGE FUNCTION

Award Number: U01HD061246
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2009
PERIOD OF PERFORMANCE END DATE: 08/31/2012

Group Awards By:

View Award Description

IRON AND MALARIA: THE CENTRAL ROLE OF HEPCIDEN AND MACAROPHAGE FUNCTION - DESCRIPTION (provided by applicant): The past decade has seen remarkable advances in our understanding of iron homeostasis, e.g. the discovery of hepcidin and other iron regulatory proteins, which may help to unravel the underlying mechanisms of the complex interaction between malaria, iron homeostasis and immune function. Based on these new insights and on recent findings of hepcidin expression in acute malaria and ex vivo human monocytes, the central hypothesis of this application is that malaria induces changes in iron regulatory proteins, including hepcidin, which subsequently affect monocyte/macrophage iron handling and innate immune responses. The goal of our application is to study how malaria influences iron regulatory proteins. This will provide leads for the development of new biomarkers for effective and safe iron supplementation and will increase our understanding of the development of some of the complications of iron supplementation. The specific aims of the current application are: 1. To obtain data from field studies whereby the influence of asymptomatic parasitemia or febrile P. vivax malaria on host iron homeostasis is explored. Both conditions follow a protracted course and hepcidin expression may influence the risk of anemia, the efficacy of iron supplementation and the incidence of infections with intracellular bacteria in malaria-endemic regions. Field studies will be carried out on the Indonesian Island Sumba, where P. falciparum and P. vivax are endemic. 2. To study the in vitro effects of P. falciparum on monocyte/macrophage iron regulatory proteins under different iron conditions and its interaction with innate immunity. Human monocytes will be incubated with cultured P. falciparum and its products and a variety of Toll like receptor agonists and blockers (to study pathways involved) with read outs on iron regulatory proteins on the mRNA level, protein level and functional level (intracellular iron contents, Salmonella killing and production of oxygen-derived radical species). PUBLIC HEALTH RELEVANCE: Anemia is an important public health problem and malaria and iron deficiency are common causes. Here we propose studies to elucidate the interaction between iron homeostasis and malaria to further optimize prevention, diagnostic and therapeutic strategies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $0 )
2013	2010	RADBOUD UNIVERSITY MEDICAL CENTER	GEERT GROOTEPLEIN 8	NIJMEGEN				NLD	Child Health and Human Development Extramural Research	000	2	7/23/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $0 )
2011	2010	RADBOUD UNIVERSITY MEDICAL CENTER	GEERT GROOTEPLEIN 8	NIJMEGEN				NLD	Child Health and Human Development Extramural Research	001	2	9/28/2011	NON-COMPETING CONTINUATION	$0
2011	2010	RADBOUD UNIVERSITY MEDICAL CENTER	GEERT GROOTEPLEIN 8	NIJMEGEN				NLD	Child Health and Human Development Extramural Research	000	2	7/7/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2010 ( Subtotal = $126,665 )
2010	2010	RADBOUD UNIVERSITY MEDICAL CENTER	tgnih06.10	NIJMEGEN				NLD	Child Health and Human Development Extramural Research	000	2	9/14/2010	NON-COMPETING CONTINUATION	$126,665
														Subtotal = $126,665

Issue Date FY: 2009 ( Subtotal = $219,988 )
2009	2009	RADBOUD UNIVERSITY MEDICAL CENTER	tgnih06.10	NIJMEGEN				NLD	Child Health and Human Development Extramural Research	000	1	9/7/2009	NEW	$219,988
														Subtotal = $219,988

Grand Total All Awards = $346,653

Top

All Categories

About

Search

Reports

Data Submission

Award Information

IRON AND MALARIA: THE CENTRAL ROLE OF HEPCIDEN AND MACAROPHAGE FUNCTION

Award Number: U01HD061246

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2009

PERIOD OF PERFORMANCE END DATE: 08/31/2012

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer