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GH13-003: Hospital - Based Surveillance of Acute Febrile Illness in Western Ghat Region of

Award Number: U01GH001051
ORGANIZATION: COORDINATING OFFICE OF GLOBAL HEALTH
OPDIV: CDC
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2013
PERIOD OF PERFORMANCE END DATE: 09/29/2018

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GH13-003: Hospital - Based Surveillance of Acute Febrile Illness in Western Ghat Region of - DESCRIPTION (provided by the applicant): Advances in laboratory diagnostics have greatly enhanced understanding of the infectious etiologies of Acute Febrile Illness (AFI) such as fever of more than a week's duration, including that of Kyasanur Forest Disease (KFD), Leptospirosis, Rickettsial disease such as Scrub Typhus, Dengue and Lyme disease in the Western Ghat region of India. This study aims to characterize the infectious causes of Acute Febrile Illness (AFI) among patients in India, in Sub-District Hospitals in Western Ghat region of India covering Karnataka, Kerala and Tamil Nadu. The study will focus on bacterial, rickettsial and viral causes of AFI. Based on historical patient volumes, it is estimated that approximately 400 patients will be enrolled (i.e., fit the study case definition) over the course of one year between the study sites in the first phase or first year of study. This study plans to roll out in the core area of Shimoga District of Karnataka in the first year to optimize on resources and roll it out to Kerala in secon y ear and Tamil Nadu in the third year. The additions from Kerala and Tamil Nadu would be 200 each. So at the end of 3rd year the intake in the study shall be 800. Patients and/or parents/guardians will be asked to participate at the time of initial presen tation, after determination by the treating clinician that a Blood profile including Complete Blood Count and Blood Culture as well as for those with neurological syndrome lumbar puncture is clinically indicated for patient management. Hospital laboratories routinely perform Gram stain, glucose/protein levels, cell count, and bacterial culture (where media/reagents are available) on cerebrospinal fluid (CSF) obtained via lumbar puncture from patients with AFI. This study would look for pathogens by using ELISA based serological tests and subject the specimen to a battery of other tests to lead to pathogen detection. In our study, clinical samples will be tested for a variety of etiologies associated with AFI such as, Bacterial pathogens (Leptospira, Salmonella, Brucella, Lyme borrelia, S. pneumoniae, H.influenzae, N. meningitidis, Shigella, Campylobacter etc. ), Rickettsial group of organisms (Scrub typhus, Spotted fever group, Ehrlichia, Anaplasma etc.) and Viruses ( KFD, Dengue, Japanese Encephalitis, West Nile Virus, Chikungunya virus, Tick borne Encephalitis virus, Crimean Congo Hemorrhagic Fever virus, Influenza viruses, Respiratory Syncytial Virus, Adenovirus, Coronaviruses, Enteroviruses, Diarrhoeagenic viruses etc.) Polymerase chain reaction (PCR) and serologic analyses of patient blood, CSF, Throat swab and Stool samples will be used to identify additional pathogens known to cause Acute febrile illness. Clinical samples also will be tested for unknown pathogens using PCR- sequence based pathogen discovery techniques.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	MANIPAL ACADEMY OF HIGHER EDUCATION	Madhav Nagar	Manipal	province	postal_code		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	05	5	5/1/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2017	MANIPAL ACADEMY OF HIGHER EDUCATION	Madhav Nagar	Manipal	KARNATAKA	576104		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	04	5	2/14/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2016	MANIPAL ACADEMY OF HIGHER EDUCATION	Madhav Nagar	Manipal	province	postal_code		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	05	5	5/1/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2015	MANIPAL ACADEMY OF HIGHER EDUCATION	Madhav Nagar	Manipal	province	postal_code		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	05	5	5/1/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2014	MANIPAL ACADEMY OF HIGHER EDUCATION	Madhav Nagar	Manipal	province	postal_code		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	05	5	5/1/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2013	MANIPAL ACADEMY OF HIGHER EDUCATION	Madhav Nagar	Manipal	province	postal_code		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	05	5	5/1/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = -$3 )
2018	2017	MANIPAL ACADEMY OF HIGHER EDUCATION	MADHAV NAGAR	MANIPAL	KARNATAKA	576104		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	000	5	10/26/2017	NON-COMPETING CONTINUATION	$0
2018	2017	MANIPAL ACADEMY OF HIGHER EDUCATION	MADHAV NAGAR	MANIPAL	KARNATAKA	576104		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	001	5	12/8/2017	NON-COMPETING CONTINUATION	$0
2018	2017	Manipal Academy Of Higher Education	Madhav Nagar	Manipal	KARNATAKA	576104		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	03	5	6/29/2018	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2018	2013	MANIPAL ACADEMY OF HIGHER EDUCATION	Madhav Nagar	Manipal	KARNATAKA	576104		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	04	1	9/7/2018	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	-$3
														Subtotal = -$3

Issue Date FY: 2017 ( Subtotal = $1,539,000 )
2017	2017	MANIPAL ACADEMY OF HIGHER EDUCATION	MADHAV NAGAR	MANIPAL	KARNATAKA	576104		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	005	5	8/31/2017	NON-COMPETING CONTINUATION	$1,434,000
2017	2017	MANIPAL ACADEMY OF HIGHER EDUCATION	MADHAV NAGAR	MANIPAL	KARNATAKA	576104		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	003	4	4/21/2017	SUPPLEMENT FOR EXPANSION	$105,000
2017	2016	MANIPAL ACADEMY OF HIGHER EDUCATION	MADHAV NAGAR	MANIPAL	KARNATAKA	576104		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	001	4	12/13/2016	NON-COMPETING CONTINUATION	$0
2017	2016	MANIPAL ACADEMY OF HIGHER EDUCATION	MADHAV NAGAR	MANIPAL	KARNATAKA	576104		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	004	4	5/30/2017	NON-COMPETING CONTINUATION	$0
2017	2016	MANIPAL ACADEMY OF HIGHER EDUCATION	MADHAV NAGAR	MANIPAL	KARNATAKA	576104		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	000	4	10/24/2016	NON-COMPETING CONTINUATION	$0
2017	2016	MANIPAL ACADEMY OF HIGHER EDUCATION	MADHAV NAGAR	MANIPAL	KARNATAKA	576104		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	002	4	1/12/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,539,000

Issue Date FY: 2016 ( Subtotal = $1,669,924 )
2016	2016	Manipal Academy of Higher Education	Madhavnagar	Manipal				IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	002	4	8/19/2016	NON-COMPETING CONTINUATION	$1,669,924
2016	2015	Manipal Academy of Higher Education	Madhavnagar	MANIPAL		576104		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	000	3	12/9/2015	NON-COMPETING CONTINUATION	$0
2016	2015	Manipal Academy of Higher Education	Madhavnagar	MANIPAL		576104		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	001	3	12/10/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,669,924

Issue Date FY: 2015 ( Subtotal = $5,906,210 )
2015	2015	Manipal Academy of Higher Education	Madhavnagar	Manipal				IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	004	3	8/22/2015	NON-COMPETING CONTINUATION	$5,836,210
2015	2015	Manipal Academy of Higher Education	Madhavnagar	Manipal				IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	001	2	1/7/2015	SUPPLEMENT FOR EXPANSION	$70,000
2015	2014	Manipal Academy of Higher Education	Madhavnagar	MANIPAL		57610		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	002	2	3/5/2015	NON-COMPETING CONTINUATION	$0
2015	2014	Manipal Academy of Higher Education	Madhavnagar	MANIPAL		57610		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	000	2	10/20/2014	NON-COMPETING CONTINUATION	$0
2015	2014	Manipal Academy of Higher Education	Madhavnagar	MANIPAL		57610		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	003	2	8/14/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $5,906,210

Issue Date FY: 2014 ( Subtotal = $230,000 )
2014	2014	Manipal Academy of Higher Education	Madhavnagar	MANIPAL		57610		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	004	2	10/20/2014	NON-COMPETING CONTINUATION	$0
2014	2014	Manipal Academy of Higher Education	Madhavnagar	Manipal				IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	003	2	7/2/2014	NON-COMPETING CONTINUATION	$230,000
2014	2013	Manipal Academy of Higher Education	Madhavnagar	MANIPAL		57610		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	002	1	7/2/2014	NEW	$0
2014	2013	Manipal Academy of Higher Education	Madhavnagar	MANIPAL		57610		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	001	1	6/10/2014	NEW	$0
2014	2013	Manipal Academy of Higher Education	Madhavnagar	MANIPAL		57610		IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	000	1	10/31/2013	NEW	$0
														Subtotal = $230,000

Issue Date FY: 2013 ( Subtotal = $250,000 )
2013	2013	Manipal University	Madhavnagar	Manipal				IND	Centers for Disease Control and Prevention Investigations and Technical Assistance	000	1	8/15/2013	NEW	$250,000
														Subtotal = $250,000

Grand Total All Awards = $9,595,131

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GH13-003: Hospital - Based Surveillance of Acute Febrile Illness in Western Ghat Region of

Award Number: U01GH001051

ORGANIZATION: COORDINATING OFFICE OF GLOBAL HEALTH

OPDIV: CDC

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2013

PERIOD OF PERFORMANCE END DATE: 09/29/2018

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