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Implementation/Evaluation of TB, HIV, and Syphilis Screening in Ethiopian Prisons

Award Number: U01GH000763
ORGANIZATION: COORDINATING OFFICE OF GLOBAL HEALTH
OPDIV: CDC
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2013
PERIOD OF PERFORMANCE END DATE: 05/31/2017

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Implementation/Evaluation of TB, HIV, and Syphilis Screening in Ethiopian Prisons - Abstract A consortium of Ethiopian and American physicians and public health experts propose implementing and studying a program of active screening for pulmonary tuberculosis (PTB), HIV, and syphilis in an Ethiopian Prison. In a pilot study at Kaliti Prison, we compared prevalence rates between entrants being admitted and long-term residents of the prison. The higher rates in residents compared to entrants for PTB symptoms (1.4 vs. 22.3%) and HIV (3.6 vs. 15.2%) suggest that transmission of both diseases is occurring in this prison. Because early detection and treatment could reduce transmission of both of these infections, we propose to screen entrants continuously and the resident population twice 12 months apart over a period of 18 months. PTB screening will consist of questions about symptoms with further evaluation to include sputum microscopy, culture and chest x-rays. HIV and syphilis serological screening will be performed in the prison by HIV rapid tests and RPR. Prisoners will be isolated during evaluation and initial treatment to reduce risk of transmission, treated according to Ethiopian national guidelines and tracked for responses to their therapy. For our operational research objectives, we will assess the program for its logistics, effectiveness and costs and for the barriers to its implementation and to participation by prisoners. We will also compare the contributions of various diagnostic modalities for PTB (symptoms, microscopy, cultures with drug susceptibility testing, and chest x-rays). For our epidemiological objectives, we will measure the baseline prevalence rates of PTB (including drug-resistant TB), HIV and syphilis in the prison population and compare rates in entrants versus long-term resident inmates. We hypothesize that these 3 diseases are transmitted within the prison and will seek further evidence for this by searching for spatial clustering of TB cases between and within prison zones. Finally as a clinical objective, we will compare the clinical presentations and treatment outcomes of prisoners diagnosed by active screening to those detected by the currently-practiced, passive (self- referral) methods for detecting TB.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2015	ETHIOPIAN PUBLIC HEALTH ASSOC IATION	MESKEL FLOWER	ADDIS ABABA	province	postal_code		ETH	Global AIDS	07	2	8/23/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2014	ETHIOPIAN PUBLIC HEALTH ASSOC IATION	MESKEL FLOWER	ADDIS ABABA	province	postal_code		ETH	Global AIDS	07	2	8/23/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2013	ETHIOPIAN PUBLIC HEALTH ASSOC IATION	MESKEL FLOWER	ADDIS ABABA	province	postal_code		ETH	Global AIDS	07	2	8/23/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	ETHIOPIAN PUBLIC HEALTH ASSOC IATION	MESKEL FLOWER	ADDIS ABABA		7117		ETH	Global AIDS	000	2	1/23/2017	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2015	ETHIOPIAN PUBLIC HEALTH ASSOCIATION	PO BOX 7117	ETHIOPIA					Global AIDS	000	2	8/23/2016	SUPPLEMENT FOR EXPANSION	$0
2016	2014	ETHIOPIAN PUBLIC HEALTH ASSOCIATION	PO BOX 7117	ETHIOPIA					Global AIDS	001	2	8/23/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $744,999 )
2015	2015	ETHIOPIAN PUBLIC HEALTH ASSOCIATION	PO BOX 7117	ETHIOPIA				ETH	Global AIDS	002	2	6/29/2015	SUPPLEMENT FOR EXPANSION	$249,999
2015	2015	ETHIOPIAN PUBLIC HEALTH ASSOCIATION	PO BOX 7117	ETHIOPIA				ETH	Global AIDS	000	2	3/24/2015	SUPPLEMENT FOR EXPANSION	$495,000
2015	2014	ETHIOPIAN PUBLIC HEALTH ASSOCIATION	PO BOX 7117	ETHIOPIA					Global AIDS	001	2	6/24/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $744,999

Issue Date FY: 2014 ( Subtotal = $5,000 )
2014	2014	ETHIOPIAN PUBLIC HEALTH ASSOCIATION	PO BOX 7117	ETHIOPIA				ETH	Global AIDS	002	2	8/29/2014	NON-COMPETING CONTINUATION	$5,000
2014	2013	ETHIOPIAN PUBLIC HEALTH ASSOCIATION	PO BOX 7117	ETHIOPIA					Global AIDS	000	1	12/16/2013	NEW	$0
2014	2013	ETHIOPIAN PUBLIC HEALTH ASSOCIATION	PO BOX 7117	ETHIOPIA					Global AIDS	001	1	7/31/2014	NEW	$0
														Subtotal = $5,000

Issue Date FY: 2013 ( Subtotal = $499,881 )
2013	2013	ETHIOPIAN PUBLIC HEALTH ASSOCIATION	PO BOX 7117	ETHIOPIA				ETH	Global AIDS	001	1	9/19/2013	NEW	-$499,881
2013	2013	ETHIOPIAN PUBLIC HEALTH ASSOCIATION	PO BOX 7117	ETHIOPIA				ETH	Global AIDS	002	1	9/20/2013	NEW	$499,881
2013	2013	ETHIOPIAN PUBLIC HEALTH ASSOCIATION	PO BOX 7117	ETHIOPIA				ETH	Global AIDS	000	1	7/26/2013	NEW	$499,881
														Subtotal = $499,881

Grand Total All Awards = $1,249,880

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Implementation/Evaluation of TB, HIV, and Syphilis Screening in Ethiopian Prisons

Award Number: U01GH000763

ORGANIZATION: COORDINATING OFFICE OF GLOBAL HEALTH

OPDIV: CDC

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2013

PERIOD OF PERFORMANCE END DATE: 05/31/2017

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