Defining targeted durations of use for tylosin phosphate to prevent liver abscess formation in feedlot cattle - Project Summary/Abstract
Antimicrobial resistance is a significant public health concern, and persistent use of
antimicrobial drugs in food animal production systems has been implicated as an important
factor contributing to its development. The expanding threat of antimicrobial resistance, which
has been recognized both domestically (CDC, 2013) and internationally (WHO, 2015), has
prompted regulatory actions aimed at preserving efficacy of antimicrobial drugs. In January of
2017, the U.S. Food and Drug Administration completed its implementation of Guidance for
Industry# 213, fully enacting policy that disallows use of medically-important antimicrobials as
growth promotants. This policy restricts use of certain medically important antibiotics to
therapeutic applications under the supervision of a licensed veterinarian. Tylosin phosphate is
among the medically important classes of compounds affected by this policy. Tylosin has been
used extensively by the beef feedlot industry for decades to reduce incidence of liver
abscesses, and generally is regarded as the most efficacious method for controlling liver
abscesses in cattle. Presence of abscesses at harvest is a primary cause for liver
condemnation, and thus has significant economic ramifications. Severe abscesses can impact
liver function, thereby decreasing animal performance and jeopardizing animal well-being.
Additionally, abscesses can expand to affect adjacent tissues, requiring affected areas to be
excised from the carcass at a significant economic loss, and also decreasing processing speed
at a cost to abattoirs. Oversight of tylosin usage in feedlots has shifted to veterinarians in
response to changes in regulatory policy, but actual usage patterns in commercial feedlots have
remained relatively unchanged. In the absence of alternative measures for control of liver
abscesses, drastic changes in usage patterns seem unlikely to occur. Tylosin currently is
approved for continuous feeding only, though there are indications that more targeted durations
of use may have efficacy equal to that of continuous feeding. Whereas replacement may not be
a viable option at present, reduction of use through strategic application presents itself as a
meaningful alternative. Commercial implementation of alternative feeding strategies for tylosin
will require labeling changes that provide for greater flexibility in its application. With this in
mind, our proposed project has several aims, the first of which is to provide additional insight
relative to the timing of liver abscess formation in feedlot cattle through non-invasive, ultrasound
imaging. Secondly, we will evaluate two different feeding strategies aimed at decreasing tylosin
use, while maintaining health outcomes similar to those achieved with continuous exposure.
