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Clinical glaucoma management enabled by visible-light OCT

Award Number: U01EY033001
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2021
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Clinical glaucoma management enabled by visible-light OCT - Project Summary This collaborative technology focused project seeks to develop, characterize, and validate visible-light optical coherence tomography (vis-OCT) as a functional tool to transform the clinical management of glaucoma. We will address two unmet needs in clinical glaucoma diagnosis and detection of progression: (1) the ability to measure retinal sublayer structure and (2) to accurately assess local retinal hemoglobin oxygen saturation (sO2). The earliest structural changes in glaucoma are thought to be a retraction of retinal ganglion cell (RGC) dendrites in the inner plexiform layer (IPL). Specifically, this would occur in the outer IPL, where RGC “off” cells synapse. Identification of loss of synapses, either by decreased scattering or by the change in IPL sublayers’ thicknesses, could serve as an earlier and more sensitive biomarker for glaucoma than any other. Measuring retinal sO2 and specific arteriole-venule couplets can determine the oxygen extraction in the regions served by those vessels. Our preliminary data indicate that regions showing damage in glaucomatous eyes have lower oxygen extraction than similar areas in healthy eyes. Our observation suggests that such oxygen extraction abnormalities can be measured well beyond the “floor effect” threshold noted with conventional OCT, allowing assessment of disease beyond the time point that conventional structural OCT becomes insensitive. To achieve our long-term goal, we will focus on new vis-OCT optical system design, imaging protocols, and data processing methodologies to identify both metabolic and ultra-fine anatomical alternations in early glaucoma, both of which are beyond the capabilities of existing imaging technologies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Vision Research	000	4	10/10/2024	NON-COMPETING CONTINUATION	$0
2025	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Vision Research	001	4	2/14/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $619,124 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Vision Research	000	4	8/28/2024	NON-COMPETING CONTINUATION	$619,124
														Subtotal = $619,124

Issue Date FY: 2023 ( Subtotal = $631,924 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Vision Research	001	3	7/12/2023	NON-COMPETING CONTINUATION	$631,924
2023	2022	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Vision Research	000	2	5/4/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $631,924

Issue Date FY: 2022 ( Subtotal = $631,924 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Vision Research	000	2	9/2/2022	NON-COMPETING CONTINUATION	$631,924
														Subtotal = $631,924

Issue Date FY: 2021 ( Subtotal = $698,124 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Vision Research	000	1	9/10/2021	NEW	$698,124
														Subtotal = $698,124

Grand Total All Awards = $2,581,096

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Clinical glaucoma management enabled by visible-light OCT

Award Number: U01EY033001

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2021

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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