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Development of Perovskite CsPbBr3 Sensors for SPECT Imaging of Higher-Energy Gamma Ray Emitters

Award Number: U01EB038438
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/09/2026
PERIOD OF PERFORMANCE END DATE: 06/30/2031

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Development of Perovskite CsPbBr3 Sensors for SPECT Imaging of Higher-Energy Gamma Ray Emitters - Project Summary/Abstract This proposed research aims to develop and evaluate CsPbBr3 (CLB) perovskite gamma-ray imaging sensors for future clinical single photon emission computer tomography (SPECT) imaging applications. CLB is an emerging perovskite semiconductor material that possesses several unique properties that make it an excellent candidate for X-ray and gamma-ray imaging applications. First, CLB has a very high effective-Z of 65.9 (compared to 50.2 for CZT) and a high density of 4.85 g/cm3, which ensures excellent stopping power and a much larger photoelectric fraction, especially at higher energies (PE ~ Z3/E3). The latter is important for SPECT to achieve an optimum energy response. These features make CLB particularly interesting for imaging alpha- emitters (e.g., Ac-225 and Ra-223) used in alpha-labeled radiopharmaceutical therapy (α-RPT), where the daughters could emit gamma-rays of 440 keV (from Bi-213) or higher energies. Second, CLB has excellent mobility-lifetime (µ-τ) products of 1.34 × 10−3 for holes and 8.77 × 10−4 cm2 V−1 for electrons, which leads to balanced charge transport and high charge collection efficiency (CCE) even in relatively thick material (>10 mm). This ensures an excellent energy resolution. Third, CLB detectors can be operated over a wide temperature range of -60°C to 70°C and exhibit excellent long-term stability (e.g., measured over the course of 18 months). Finally, CLB can be produced with easily scalable crystal growth processes and exhibits a much higher tolerance to impurities during crystal growth, leading to a significantly reduced production cost compared to CZT. In this project, we will build on the recent advances in CLB detector material growth and fabrication techniques and readout electronics to develop a modular CLB sensor platform that can be scaled up into a large-area detection system for future SPECT instruments.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $874,500 )
2026	2026	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/7/2026	NEW	$874,500
														Subtotal = $874,500

Grand Total All Awards = $874,500

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Development of Perovskite CsPbBr3 Sensors for SPECT Imaging of Higher-Energy Gamma Ray Emitters

Award Number: U01EB038438

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/09/2026

PERIOD OF PERFORMANCE END DATE: 06/30/2031

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