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Automated Mobile Microscopy for Malaria Diagnosis and surveillance in Uganda

Award Number: U01EB035483
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/18/2023
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Automated Mobile Microscopy for Malaria Diagnosis and surveillance in Uganda - Project Summary Malaria is one of the leading health problems of the developing world. Malaria endemicity has been attributed to poor diagnosis at the lab level. This quite often leads to disease misdiagnosis and drug resistance. Many developing countries are faced with a lack of critical mass of lab technicians to diagnose the disease through a gold standard mechanism of microscopy and this has worsened the already dire situation in some of these Countries. World over the trending technologies are now based on machine learning and deep learning techniques. These can be leveraged with the combination of smartphones to improve disease diagnosis. However, most of the previous work on automation for microscopy diagnosis has been carried out adhocly in the lab environment and no study seems to give a practical field deployable solution. The goal of the proposed research is to develop a rapid, low cost, accurate and simple in-field screening system for microscopy challenges like malaria. Specifically, this study will test and validate developed image analysis models for real time field-based diagnostics and surveillance of malaria. The proposed solution builds from our earlier work on mobile microscopy carried out at Makerere University AI Lab, that has confronted automated microscopy through exploiting recent technological advances in 3D printing to enable development of a low-cost 3D printed adapter. This has enabled attachment of a wide range of Smartphones on a microscope, furthermore, we have implemented deep learning models for pathogen detection to produce effective hardware and software respectively. The software component of our work is to train machine learning methods to recognise different pathogen objects. The diagnosis solutions have however been ad-hoc in its current state where different conditional settings like image scaling, phone resolutions and grid readings were not standardized and therefore poor performance of the model when deployed in field testing. Our Infield automated screening trials will therefore involve achieving robust outcomes, through 1) Development of machine learning approaches for standardised field-based microscopy of malaria diagnosis in Uganda. 2) Building a complementary framework for real time surveillance and improved diagnosis of malaria platform through in-field diagnostic studies. The point-of-care field-based diagnostic system proposed here addresses a major unmet public health malaria screening and surveillance need to reliably inform public health interventions in malaria control and prevention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $240,268 )
2025	2025	MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES	CLINICAL RESEARCH BUILDING NEW MULAGO HILL ROAD	KAMPALA				UGA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	7/29/2025	NON-COMPETING CONTINUATION	$240,268
														Subtotal = $240,268

Issue Date FY: 2024 ( Subtotal = $248,962 )
2024	2024	MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES	CLINICAL RESEARCH BUILDING NEW MULAGO HILL ROAD	KAMPALA				UGA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	8/1/2024	NON-COMPETING CONTINUATION	$248,962
														Subtotal = $248,962

Issue Date FY: 2023 ( Subtotal = $262,191 )
2023	2023	MAKERERE UNIVERSITY COLLEGE O F HEALTH SCIENCES	CLINICAL RESEARCH BUILDING NEW MULAGO HILL ROAD	KAMPALA				UGA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/18/2023	NEW	$262,191
														Subtotal = $262,191

Grand Total All Awards = $751,421

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Automated Mobile Microscopy for Malaria Diagnosis and surveillance in Uganda

Award Number: U01EB035483

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/18/2023

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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