Tuesday, February 18, 2025 2/18/2025

The Neuroscience of Everyday World- A novel wearable system for continuous measurement of brain function

Award Number: U01EB029856
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Innovations in human neuroimaging tools have driven profound advances in our understanding of brain function under well-controlled and constrained conditions. While we are gaining greater understanding of how the brain functions in single-snapshot experiments under restricted lab settings, we do not know how it works in dynamic, complex and multisensory real-world environments. The goal of this project is to build a portable, miniaturized, lightweight, high-density wearable combined – functional Near Infrared-Spectroscopy (fNIRS) – Electro-Encepholography (EEG) - Eye-tracking system for enabling “Neuroscience of the Everyday World (NEW)” by permitting long duration continuous monitoring of normal / altered brain activity during movement, perception, and social interaction in real time and in the real world. In Aim 1, We will (A) develop a wearable and fully hybrid high-density EEG-fNIRS system that supports autonomous long-term recordings (>6 hours), (B) develop combined and miniaturized active EEG-Electrodes / fNIRS-Optodes; and (C) integrate the wearable system with Tobii Pro 2 eye-tracking/scene-camera glasses and state- of-the-art computer vision for adaptive acquisition and automated data annotation. In Aim 2, we will measure brain activity during walking, perceiving, and interacting, with experiments gradually increasing in complexity through three phases from lab to real world settings in young healthy adults and conduct a proof of principle in two sample clinical populations. In Aim 3, we will create an analysis workflow for data collected in Aim 2 that will accomplish the following: (1) removing nuisance signals from fNIRS/EEG signals, (2) analysis of multimodal fNIRS/EEG and behavioral data, (3) automatic annotation of and adaptation for real world measurements. This project brings together engineers, scientists and clinicians with the goal of building the next generation of imaging tools to capture brain function in real time. With our technological sophistication, interdisciplinary focus, and ready access to well-characterized clinical populations, we are uniquely positioned to successfully develop, apply, and disseminate our NEW technology, and lay down a foundation upon which groundbreaking advances in our understanding of the links between brain activity and behavior will build.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	12/30/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $980,087 )
2024	2024	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	6/6/2024	NON-COMPETING CONTINUATION	$980,087
														Subtotal = $980,087

Issue Date FY: 2023 ( Subtotal = $1,597,493 )
2023	2023	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	9/8/2023	SUPPLEMENT FOR EXPANSION	$409,770
2023	2023	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	4	9/11/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2023	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	7/31/2023	NON-COMPETING CONTINUATION	$1,187,723
														Subtotal = $1,597,493

Issue Date FY: 2022 ( Subtotal = $1,358,265 )
2022	2022	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	5/31/2022	NON-COMPETING CONTINUATION	$1,358,265
2022	2021	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	12/1/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,358,265

Issue Date FY: 2021 ( Subtotal = $1,373,229 )
2021	2021	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	9/10/2021	SUPPLEMENT FOR EXPANSION	$164,734
2021	2021	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	7/6/2021	NON-COMPETING CONTINUATION	$1,208,495
														Subtotal = $1,373,229

Issue Date FY: 2020 ( Subtotal = $1,238,194 )
2020	2020	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/15/2020	NEW	$1,238,194
														Subtotal = $1,238,194

Grand Total All Awards = $6,547,268

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The Neuroscience of Everyday World- A novel wearable system for continuous measurement of brain function

Award Number: U01EB029856

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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