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MIRDCalc – A Community Tool for Deriving and Reporting Patient Organ Doses in Nuclear Medicine, Computed Tomography, and Hybrid Imaging

Award Number: U01EB028234
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/13/2019
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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MIRDCalc – A Community Tool for Deriving and Reporting Patient Organ Doses in Nuclear Medicine, Computed Tomography, and Hybrid Imaging - Project Summary The assessment of radiation organ absorbed dose to patients plays a critical role in both the development and clinical use of radiopharmaceuticals for both diagnostic imaging (cancer/disease detection) and radiation therapy (cancer treatment). Dosimetry also provides the basis of imaging/treatment optimization, and its accessibility and maturation will help define personalized medicine as applied to medical imaging and nuclear therapies in the coming decades. A variety of software codes exist for patient dosimetry in nuclear medicine, but they tend to reside within two extremes of functionality. At one end are more simplistic NM dosimetry tools that merge animal- derived or personalized biodistribution data with standard (population-averaged) models, a technique that has proved valuable historically but has seen minimal technological advancement. At the other end are complex NM dosimetry codes that import patient-specific CT/PET/SPECT images and allow for accurate, but computationally intensive, Monte Carlo simulation-based dosimetry. The issue with these higher-end codes is that they are much more nuanced, resource intensive, and tend to only reside within research-based medical institutions with expert support staff. In this Biomedical Research Partnership between MSK and UF, a new generation of nuclear medicine patient dosimetry code will be developed and released at no cost to the imaging and clinical community. The code – MIRDcalc – is built upon the universally available Microsoft Excel platform and can be used with an easy interactive interface or automated DOS command line. The database powering MIRDcalc stores all necessary information for implementing biodistribution-to-dosimetry calculations using the MIRD schema. The current generation of MIRDcalc thus will not include acquisition and derivation of the input time-activity data, which is beyond the scope of the current application, but will be incorporated into future versions of this code. It includes radionuclide S values for 333 radioisotopes, associated with 12 modern ICRP reference phantoms each with 58 source organs and 44 target organs and is readily expandable to accommodate additional isotopes and phantoms. The MIRDcalc software will be a free tool providing dosimetry that meets current standards, and a platform for further innovations as well as a central framework for supporting a dosimetry user community. Our planned innovations address issues of personalization, uncertainty calculation, documentation, and other key considerations. Of note, and a key feature of this partnership, is the addition of CT organ dosimetry to MIRDcalc, which presently does not exist in any current nuclear medicine software code despite the universal adoption of combination PET-CT and the ever-increasing penetration of SPECT-CT scanners in diagnostic radiology and nuclear medicine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$100,263 )
2026	2023	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	11/20/2025	NON-COMPETING CONTINUATION	-$100,263
														Subtotal = -$100,263

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	8/16/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $607,829 )
2023	2023	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	6/15/2023	NON-COMPETING CONTINUATION	$607,829
														Subtotal = $607,829

Issue Date FY: 2022 ( Subtotal = $622,201 )
2022	2022	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	9/2/2022	NON-COMPETING CONTINUATION	$622,201
														Subtotal = $622,201

Issue Date FY: 2021 ( Subtotal = $624,385 )
2021	2021	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	7/23/2021	NON-COMPETING CONTINUATION	$624,385
2021	2020	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	3/12/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $624,385

Issue Date FY: 2020 ( Subtotal = $652,054 )
2020	2020	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	6/23/2020	NON-COMPETING CONTINUATION	$652,054
														Subtotal = $652,054

Issue Date FY: 2019 ( Subtotal = $664,325 )
2019	2019	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/13/2019	NEW	$664,325
														Subtotal = $664,325

Grand Total All Awards = $3,070,531

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MIRDCalc – A Community Tool for Deriving and Reporting Patient Organ Doses in Nuclear Medicine, Computed Tomography, and Hybrid Imaging

Award Number: U01EB028234

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/13/2019

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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