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Wills Eye Community Intervention to Improve Glaucoma Detection and Follow-up Care

Award Number: U01DP005127
ORGANIZATION: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION & HEALTH PROMOTION
OPDIV: CDC
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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DESCRIPTION (provided by applicant): Glaucoma is a chronic optic neuropathy resulting in visual field defects and progressive, irreversible vision loss. Glaucoma is the second leading cause of blindness in the United States. Primary open-angle glaucoma is the most common form. Rates of glaucoma are projected to increase by 50% to 3.36 million people by 2020, causing a significant economic and quality of life burden. Risk factors for glaucoma include advanced age (65+ years), family history of glaucoma, race (African American, Asian), and ethnicity (Hispanic/Latino). Diabetes is also an independent risk factor for glaucoma. African Americans develop glaucoma at a younger age, progress more rapidly, and are almost 7 times more likely to go blind than non-Hispanic Caucasians. Despite the advanced technology and available diagnostic testing, 50% of people with glaucoma remain undiagnosed. When glaucoma is diagnosed in its early stages, appropriate treatment and management can almost always prevent blindness. Under the leadership of L. Jay Katz, MD; Julia A. Haller, MD; and Lisa Hark, PhD, RD, the Wills Eye Glaucoma Research Center will conduct a 5-year prospective, randomized controlled trial to test an innovative community intervention using fundus photography of the optic nerve and macula (telemedicine) to detect, treat, and manage high-risk patients with previously undiagnosed glaucoma and other eye diseases. Our diverse, targeted at-risk population includes African Americans, Hispanics and Asian over age 40; older adults (aged 65+); and those over age 40 with a family history of glaucoma and/or diabetes. Phase 1 will consist of recruiting approximately 2,000 patients from 14 primary care offices and 10 federally qualified health centers across Philadelphia and Chester counties with our community partners. Using telemedicine, we will detect eye disease using telemedicine (Visit 1) followed by a comprehensive eye exam by a glaucoma specialist to confirm the diagnosis (Visit 2). Based on preliminary data, 30% of patients (approximately 600) will have abnormal optic nerve and/or macula images. The predictive accuracy of the optic nerve images to detect glaucoma and glaucoma suspect as confirmed by the comprehensive eye exam will be evaluated. Phase 2 will involve consenting, enrolling, and randomizing 300 patients to either the usual care group (n=150) or the enhanced intervention group (n=150) and scheduling follow-up eye exams with local, general ophthalmologists (Visit 3). The enhanced intervention will consist of using patient navigators and a social worker to reduce barriers to follow-up eye care. Phase 3 will consist of following patients proximally (6 months) and distally (3 years) while they attend ophthalmology appointments (Visits 4-8). Adherence to follow-up recommendations for eye care will be the primary outcome measure. A comprehensive cost study to estimate the intervention costs and cost-effectiveness of detecting eye diseases and vision impairment in a high-risk population will also be conducted. Protocols, materials, and results will be disseminated to other communities in order to expand detection of glaucoma, other eye diseases, and visual impairment, and to further refine these approaches.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2018	CITY OF PHILADELPHIA, TRUSTEE, UNDER THE WILL OF JAMES WILLS	840 WALNUT ST STE 1530	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	06	5	9/10/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2021	2017	CITY OF PHILADELPHIA, TRUSTEE, UNDER THE WILL OF JAMES WILLS	840 WALNUT ST STE 1530	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	06	5	9/10/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2021	2016	CITY OF PHILADELPHIA, TRUSTEE, UNDER THE WILL OF JAMES WILLS	840 WALNUT ST STE 1530	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	06	5	9/10/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2021	2015	CITY OF PHILADELPHIA, TRUSTEE, UNDER THE WILL OF JAMES WILLS	840 WALNUT ST STE 1530	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	06	5	9/10/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2021	2014	CITY OF PHILADELPHIA, TRUSTEE, UNDER THE WILL OF JAMES WILLS	840 WALNUT ST STE 1530	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	06	5	9/10/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	CITY OF PHILADELPHIA, TRUSTEE, UNDER THE WILL OF JAMES WILLS	840 WALNUT ST STE 1530	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	05	5	5/14/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2020	2017	CITY OF PHILADELPHIA, TRUSTEE, UNDER THE WILL OF JAMES WILLS	840 WALNUT ST STE 1530	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	05	5	5/14/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2018	CITY OF PHILADELPHIA, TRUSTEE, UNDER THE WILL OF JAMES WILLS	840 WALNUT ST STE 1530	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	03	5	4/1/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2018	CITY OF PHILADELPHIA, TRUSTEE, UNDER THE WILL OF JAMES WILLS	840 WALNUT ST STE 1530	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	01	5	12/10/2018	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2018	CITY OF PHILADELPHIA, TRUSTEE, UNDER THE WILL OF JAMES WILLS	840 WALNUT ST STE 1530	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	04	5	7/29/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2018	CITY OF PHILADELPHIA, TRUSTEE, UNDER THE WILL OF JAMES WILLS	840 WALNUT ST STE 1530	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	02	5	3/21/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2017	CITY OF PHILADELPHIA, TRUSTEE, UNDER THE WILL OF JAMES WILLS	840 WALNUT ST STE 1530	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	02	5	3/21/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2017	CITY OF PHILADELPHIA, TRUSTEE, UNDER THE WILL OF JAMES WILLS	840 WALNUT ST STE 1530	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	04	5	7/29/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2017	CITY OF PHILADELPHIA, TRUSTEE, UNDER THE WILL OF JAMES WILLS	840 WALNUT ST STE 1530	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	03	5	4/1/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $600,000 )
2018	2018	CITY OF PHILADELPHIA, TRUSTEE, UNDER THE WILL OF JAMES WILLS	840 WALNUT ST STE 1530	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	00	5	7/1/2018	NON-COMPETING CONTINUATION	$600,000
2018	2017	CITY OF PHILADELPHIA, TRUSTEE, UNDER THE WILL OF JAMES WILLS	840 WALNUT ST STE 1530	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	000	4	12/8/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $600,000

Issue Date FY: 2017 ( Subtotal = $600,000 )
2017	2017	CITY OF PHILADELPHIA, TRUSTEE, UNDER THE WILL OF JAMES WILLS	840 WALNUT ST STE 1530	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	000	4	7/24/2017	NON-COMPETING CONTINUATION	$600,000
														Subtotal = $600,000

Issue Date FY: 2016 ( Subtotal = $600,000 )
2016	2016	Willis Eye Health System	840 Walnut Street	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	000	3	7/14/2016	NON-COMPETING CONTINUATION	$600,000
														Subtotal = $600,000

Issue Date FY: 2015 ( Subtotal = $600,000 )
2015	2015	Willis Eye Health System	840 Walnut Street	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	002	2	6/25/2015	NON-COMPETING CONTINUATION	$600,000
2015	2014	Willis Eye Health System	840 Walnut Street	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	001	1	2/4/2015	NEW	$0
2015	2014	Willis Eye Health System	840 Walnut Street	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	000	1	1/23/2015	NEW	$0
														Subtotal = $600,000

Issue Date FY: 2014 ( Subtotal = $600,000 )
2014	2014	Willis Eye Health System	840 Walnut Street	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	000	1	8/26/2014	NEW	$600,000
														Subtotal = $600,000

Grand Total All Awards = $3,000,000

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Wills Eye Community Intervention to Improve Glaucoma Detection and Follow-up Care

Award Number: U01DP005127

ORGANIZATION: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION & HEALTH PROMOTION

OPDIV: CDC

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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