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Improving disease subtyping and physiological characterization of adult-onset diabetes in electronic health records

Award Number: U01DK140952
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Improving disease subtyping and physiological characterization of adult-onset diabetes in electronic health records - ABSTRACT Diabetes is broadly classified as type 1 diabetes (T1D), with primary defect in insulin production due to autoimmune destruction of beta cells, and type 2 diabetes (T2D), with primary defect in insulin sensitivity in organs that regulate energy metabolism. There is an emerging conceptual change that diabetes is not composed of discrete sets of syndromes but a spectrum of heterogenous phenotypes with complex pathophysiology across different ethnic and racial populations. More than 90% of adult patients with diabetes are classified as T2D with variable clinical risk factors, prognosis, and treatment response. There is an unmet need to assess individual risk for developing diabetes, its complications, and drug response based on underlying pathophysiology, which change over time. This proposal will embark on studies of large-scale electronic health records (EHRs) with comprehensive phenome assessed during the course of diabetes, and multi-omics integration, to address the following Specific Aims. AIM 1: Classification of diabetes subtypes using clinical features in EHRs of diverse ancestries. AIM 2: Classification of diabetes subtypes in response to treatments for diabetes and cardiometabolic diseases in EHRs of diverse ancestries. AIM 3: Multi-omics characterization of diabetes subtypes in African Americans. Successful implementation of the proposal will build a framework to identify subtypes of diabetes and their underlying physiological drivers to impact clinical practice towards more precise diagnosis, prognosis, and effective intervention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $867,269 )
2026	2026	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	8/20/2026	NON-COMPETING CONTINUATION	$867,269
2026	2025	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	4/3/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $867,269

Issue Date FY: 2025 ( Subtotal = $862,769 )
2025	2025	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	8/12/2025	NON-COMPETING CONTINUATION	$862,769
														Subtotal = $862,769

Issue Date FY: 2024 ( Subtotal = $596,339 )
2024	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	8/19/2024	NEW	$596,339
														Subtotal = $596,339

Grand Total All Awards = $2,326,377

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Improving disease subtyping and physiological characterization of adult-onset diabetes in electronic health records

Award Number: U01DK140952

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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