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The Bidirectional Gut-Microbiota-Brain Axis in Parkinson’s disease: integrating mechanistic biomarkers of disease severity and progression

Award Number: U01DK140923
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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The Bidirectional Gut-Microbiota-Brain Axis in Parkinson’s disease: integrating mechanistic biomarkers of disease severity and progression - PROJECT SUMMARY/ABSTRACT This Administrative Supplement Request to U01 DK140923 at Rush University Medical Center (RUMC) / Medical University of South Carolina (MUSC) will significantly enhance the Gut Brain Parkinson's Disease Consortium (GBPDC) by integrating additional crucial gastrointestinal and neurological assessments. Specifically, we propose to add a videofluoroscopic swallowing study, anorectal manometry/ balloon expulsion, intestinal transit time, advanced microbiota metabolomics, and skin biopsies outcomes / readouts that are consistent with the Consortium Master Protocol. These added assessments were approved by the U01 Steering Committee, but not included nor budgeted in our original funded grant. Our center was selected by the Steering Committee to take on the added responsibility to analyze samples from an additional 200 subjects from the other participation centers within the GBPDC consortium. These studies focus on the microbiome (including culturomics), intestinal barrier integrity, and we have the expertise to do this work on behalf of the UO1 group. These additional data will significantly amplify the consortium's ability to identify novel gut -based biomarkers, diagnostic tools, and therapeutic targets for Parkinson's Disease, accelerating our understanding of the Gut-Microbiota-Brain Axis's role in Parkinson’s Disease pathogenesis and progression, and fostering inter-project collaboration.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $926,441 )
2025	2025	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/14/2025	NON-COMPETING CONTINUATION	$712,359
2025	2025	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	8/6/2025	SUPPLEMENT FOR EXPANSION	$214,082
														Subtotal = $926,441

Issue Date FY: 2024 ( Subtotal = $514,873 )
2024	2024	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	8/9/2024	NEW	$514,873
														Subtotal = $514,873

Grand Total All Awards = $1,441,314

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The Bidirectional Gut-Microbiota-Brain Axis in Parkinson’s disease: integrating mechanistic biomarkers of disease severity and progression

Award Number: U01DK140923

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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