Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Identify risk factors for type 2 diabetes in adolescents

Award Number: U01DK135015
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/19/2023
PERIOD OF PERFORMANCE END DATE: 01/31/2029

Group Awards By:

View Award Description

Identify risk factors for type 2 diabetes in adolescents - Type 2 diabetes (T2D), a condition marked by substantial physical and psychological morbidity, is increasingly diagnosed in youth but is still infrequent even in high-risk obese adolescents. There are significant racial, ethnic, and socioeconomic effects in youth at risk for the development of T2D, but we do not know how to easily identify which youth will and will not develop T2D, nor do we know specifics about the mechanisms behind the early development of T2D. To address these research gaps amongst others, we propose an appropriately powered prospective cohort study of 3500 youth in response to RFA DK-21-002 Understanding and Targeting the Pathophysiology of Youth-Onset Type 2 Diabetes-Clinical Centers. As the Columbus Clinical Center (CCC), our interdisciplinary team will leverage our large clinical network in urban and rural settings in Ohio AND cumulative experience and expertise caring for youth with obesity and type 2 diabetes, recruiting and retention in prospective clinical/cohort trials and diagnostic testing for diabetes. In addition, we propose mechanistic studies drawing from our prior studies on insulin sensitivity and secretion, β-cell function, innate immune response genes, inflammatory markers, and microbiome. As the CCC, we plan to recruit and retain a cohort of 250 youth aged 9-13 years with obesity (age and sex-specific body mass index (BMI) ≥ 95%tile) with impaired fasting glucose (IFG) (100-125mg/dl) or impaired glucose tolerance (IGT) (140–199mg/dl) in urban and rural Ohio counties over 30 months and propose. Subjects will be followed to determine the pattern and trajectory of anthropometric change (weight, BMI, Tanner stage) as risk factors for T2D, and to investigate a risk phenotype for youth for T2D based on a) social determinants of health, b) lifestyle behaviors and c) psychosocial factors. Oral glucose tolerance tests will be performed every 6 months to diagnosis diabetes and also to assess insulin sensitivity and secretion changes that identify early risk for development of T2D. Continuous glucose monitoring (CGM) and hemoglobin A1c levels will also be assessed throughout the study to identify early markers for development of T2D. Lastly, blood and stool samples will be collected and saved for future assessment of genetic, inflammatory and microbiome factors that play a mechanistic role in the development of T2D. The results of this study will have broad clinical and social impact by identifying youth specifically at risk for T2D and by identifying specific psychosocial risk factors for adolescent T2D. They will have research impact by identifying mechanistic factors for the development of adolescent T2D that may be targeted in future interventional studies to prevent the disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $684,084 )
2025	2025	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	3	2/21/2025	NON-COMPETING CONTINUATION	$0
2025	2025	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	2/17/2025	NON-COMPETING CONTINUATION	$684,083
2025	2024	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	2/14/2025	NON-COMPETING CONTINUATION	$1
														Subtotal = $684,084

Issue Date FY: 2024 ( Subtotal = $776,587 )
2024	2024	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	3/8/2024	NON-COMPETING CONTINUATION	$698,928
2024	2024	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	6/18/2024	NON-COMPETING CONTINUATION	$77,659
														Subtotal = $776,587

Issue Date FY: 2023 ( Subtotal = $57,952 )
2023	2023	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	4/19/2023	NEW	$57,952
														Subtotal = $57,952

Grand Total All Awards = $1,518,623

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Identify risk factors for type 2 diabetes in adolescents

Award Number: U01DK135015

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/19/2023

PERIOD OF PERFORMANCE END DATE: 01/31/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer