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Building a multi-scale vascular atlas of the mouse lower urinary tract

Award Number: U01DK131384
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Building a multi-scale vascular atlas of the mouse lower urinary tract - ABSTRACT This GUDMAP Atlas project is focused on the lower urinary tract (LUT; bladder and urethra) of male and female mice. The Specific Aims are to build 3D multiscale anatomical atlases of (1) the mouse LUT vasculature and (2) the autonomic and sensory innervation of this vasculature. Times of the life cycle from embryo to adult have been selected to reveal the impact of major changes in organ structure and function on vascular patterning. The outcomes of Aim 1 will fill a major gap in GUDMAP and the broader literature, where LUT vascular structures have been under-explored in comparison with LUT muscle wall and epithelium. The outcomes of Aim 2 will provide a second important dimension to GUDMAP and the literature, by superimposing on the vascular atlases the closely associated axonal plexuses (sensory and autonomic) that regulate LUT vascular function. Most of these axon classes do not originate from pelvic ganglia, so provide to the GUDMAP database new resources that are quite distinct from the existing knowledge base. In addition to developing new knowledge on the vascular system, the outcomes of the project will support generation of new hypotheses on LUT function in health and disease. .


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $297,867 )
2024	2024	UNIVERSITY OF MELBOURNE	RAYMOND PRIESTLEY BLDG UNIV OF MELB	MELBOURNE	VICTORIA			AUS	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	7/16/2024	NON-COMPETING CONTINUATION	$297,867
2024	2023	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	3/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $297,867

Issue Date FY: 2023 ( Subtotal = $321,387 )
2023	2023	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	8/3/2023	NON-COMPETING CONTINUATION	$321,387
														Subtotal = $321,387

Issue Date FY: 2022 ( Subtotal = $321,387 )
2022	2022	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	7/28/2022	NON-COMPETING CONTINUATION	$321,387
2022	2021	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	1/24/2022	NEW	$0
														Subtotal = $321,387

Issue Date FY: 2021 ( Subtotal = $319,767 )
2021	2021	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/20/2021	NEW	$319,767
														Subtotal = $319,767

Grand Total All Awards = $1,260,408

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Building a multi-scale vascular atlas of the mouse lower urinary tract

Award Number: U01DK131384

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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