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Modulation and functional characterization of protein condensation in chromatin organization

Award Number: U01DK127421
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Modulation and functional characterization of protein condensation in chromatin organization - Project Summary Recent discoveries of the phase-separation abilities of several chromatin regulators have led to novel models for chromatin organization. Directly testing the causal effects of phase-separation mechanisms requires an ability to quantitatively tune the phase-separation ability of an endogenous chromatin regulator and simultaneously test for gene expression and cell fate changes. For this goal, we will develop two tool kits: (1) a phase-dial to enhance or suppress the phase-separation potential of endogenous proteins in a quantitative and controlled manner, and (2) a robust and transferrable technological platform to correlate live imaging of phase condensates with the profiling of gene expression at the single cell level. Utilizing these tools, we will study the regulation and impact of heterochromatin formation and transcription activation during stem cell differentiation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$2 )
2026	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Trans-NIH Research Support	000	5	11/25/2025	NON-COMPETING CONTINUATION	-$2
														Subtotal = -$2

Issue Date FY: 2024 ( Subtotal = $1,086,587 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Trans-NIH Research Support	000	5	7/10/2024	NON-COMPETING CONTINUATION	$1,086,587
														Subtotal = $1,086,587

Issue Date FY: 2023 ( Subtotal = $1,086,587 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Trans-NIH Research Support	001	4	8/8/2023	NON-COMPETING CONTINUATION	$1,086,587
2023	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Trans-NIH Research Support	000	3	6/19/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,086,587

Issue Date FY: 2022 ( Subtotal = $1,086,587 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Trans-NIH Research Support	001	3	6/30/2022	NON-COMPETING CONTINUATION	$1,086,587
2022	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Trans-NIH Research Support	000	2	1/31/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,086,587

Issue Date FY: 2021 ( Subtotal = $1,086,587 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Trans-NIH Research Support	000	2	7/23/2021	NON-COMPETING CONTINUATION	$1,086,587
														Subtotal = $1,086,587

Issue Date FY: 2020 ( Subtotal = $1,086,587 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Trans-NIH Research Support	000	1	9/15/2020	NEW	$1,086,587
														Subtotal = $1,086,587

Grand Total All Awards = $5,432,933

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Modulation and functional characterization of protein condensation in chromatin organization

Award Number: U01DK127421

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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