Thursday, January 22, 2026 1/22/2026

Clinical, Radiologic and Biochemical Factors Related to Diabetes Development after Acute Pancreatitis

Award Number: U01DK127400
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2020
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Clinical, Radiologic and Biochemical Factors Related to Diabetes Development after Acute Pancreatitis - Abstract Nearly 40% of patients develop diabetes after an initial episode of acute pancreatitis (AP). Various studies have evaluated risk factors for the development of diabetes but they have shown inconsistent findings, suggesting methodologic shortcomings. The present proposal consists of three specific aims where we will attempt to determine the biochemical, radiologic and clinical factors related to the development of diabetes after AP. Aim 1: To identify autoantibodies associated with the progression of type 1 diabetes in patients after AP using a large human proteome array. Aim 2: To study the role of imaging, more specifically quantitative textural analysis to predict the development of type 1 diabetes after AP. Aim 3 is to build a machine learning model to predict type 1 diabetes after AP using patient-related risk factors, textural analysis on imaging and autoantibodies involved in disease progression. Our proposal will help us better understand diabetes after AP. Successful completion of this study has the potential to improve management for AP.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	11/24/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $443,000 )
2025	2025	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	9/10/2025	COMPETING CONTINUATION	$443,000
2025	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	5/1/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $443,000

Issue Date FY: 2024 ( Subtotal = $286,563 )
2024	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	8/1/2024	NON-COMPETING CONTINUATION	$286,563
2024	2023	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	5/8/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $286,563

Issue Date FY: 2023 ( Subtotal = $286,563 )
2023	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	7/31/2023	NON-COMPETING CONTINUATION	$286,563
2023	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	5/11/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $286,563

Issue Date FY: 2022 ( Subtotal = $286,563 )
2022	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	7/22/2022	NON-COMPETING CONTINUATION	$286,563
2022	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	10/15/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $286,563

Issue Date FY: 2021 ( Subtotal = $286,563 )
2021	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/28/2021	NON-COMPETING CONTINUATION	$286,563
														Subtotal = $286,563

Issue Date FY: 2020 ( Subtotal = $286,563 )
2020	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/16/2020	NEW	$286,563
														Subtotal = $286,563

Grand Total All Awards = $1,875,815

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Clinical, Radiologic and Biochemical Factors Related to Diabetes Development after Acute Pancreatitis

Award Number: U01DK127400

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2020

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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