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ChartGlucose4Moms: Characterizing by Trimester, Continuous Glucose Monitoring Measurements for determining effects on Maternal & Offspring Metabolic Sequelae

Award Number: U01DK123791
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Protocol Summary/Abstract In the setting of increasing prevalence of obesity and pre-diabetes, there is growing interest in identification of hyperglycemia in early pregnancy to facilitate treatment and minimize fetal exposure. Although multiple organizations recommend first trimester diabetes screening among individuals with risk factors, the benefits and drawbacks of detecting glucose abnormalities short of frank diabetes and optimal screening method in early gestation remain unclear. The overarching goal of the NIDDK-supported ChartGlucose4Moms: Characterizing, by Trimester, Continuous Glucose Monitoring Measurements for determining effects on Maternal & Offspring Metabolic Sequelae study (aka, Glycemic Observation and Metabolic Outcomes in Mothers and offspring (GO MOMs) study) is to evaluate how early pregnancy glycemia, measured using continuous glucose monitoring (CGM) and oral glucose tolerance testing (OGTT), relates to gestational diabetes (GDM) diagnosis at 24-28 weeks' gestation (maternal primary outcome) and large-for-gestational-age (newborn primary outcome). A secondary objective is to perform comprehensive, longitudinal assessment of changes in glucose over the course of pregnancy. Enrollment began in April 2021 and will continue for 3.5 years with a target sample size of 2150 participants (200 of which are being recruited at KPNW). GO MOMs will yield data that are vital to improving our understanding of hyperglycemia in pregnancy, facilitate improved approaches for GDM screening in early pregnancy, and inform future clinical trials of early GDM treatment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $525,614 )
2024	2024	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	8/28/2024	NON-COMPETING CONTINUATION	$477,014
2024	2024	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	5	8/29/2024	SUPPLEMENT FOR EXPANSION	$48,600
2024	2023	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	3/29/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $525,614

Issue Date FY: 2023 ( Subtotal = $538,992 )
2023	2023	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	4	9/4/2023	NON-COMPETING CONTINUATION	$538,992
2023	2022	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	4/26/2023	NON-COMPETING CONTINUATION	$0
2023	2022	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	7/27/2023	NON-COMPETING CONTINUATION	$0
2023	2019	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	1	8/9/2023	NEW	$0
														Subtotal = $538,992

Issue Date FY: 2022 ( Subtotal = $673,230 )
2022	2022	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	3	9/6/2022	NON-COMPETING CONTINUATION	$673,230
2022	2020	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	5/10/2022	NON-COMPETING CONTINUATION	$0
2022	2020	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	1/13/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $673,230

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	11/26/2020	NON-COMPETING CONTINUATION	$0
2021	2020	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	2	6/23/2021	NON-COMPETING CONTINUATION	$0
2021	2020	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	2/19/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $662,614 )
2020	2020	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	9/1/2020	NON-COMPETING CONTINUATION	$662,614
														Subtotal = $662,614

Issue Date FY: 2019 ( Subtotal = $800,511 )
2019	2019	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/20/2019	NEW	$800,511
														Subtotal = $800,511

Grand Total All Awards = $3,200,961

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ChartGlucose4Moms: Characterizing by Trimester, Continuous Glucose Monitoring Measurements for determining effects on Maternal & Offspring Metabolic Sequelae

Award Number: U01DK123791

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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