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PREcision Medicine through IntErrogation of Rna in the kidnEy (PREMIERE)

Award Number: U01DK114907
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2017
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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PREcision Medicine through IntErrogation of Rna in the kidnEy (PREMIERE) - ABSTRACT The kidney has developed a complex, three-dimensional architecture to serve its key functions, including excretion of waste substances, maintenance of the internal balance for fluid and salt, blood pressure control, and hormonal function. Understanding the roles of the individual renal cell types and cell states in these processes in health and disease is critical to develop novel targeted therapies. Extensive studies lead by this investigative group and others have started to identify molecular disease mechanism in renal biopsy tissues and helped to develop novel disease markers and therapies. The PREcision Medicine through IntErrogation of Rna in the kidnEy (PREMIERE) Network has brought investigators from three leading biomedical research institutions with diverse, complementary expertise together. Our team has an established track record in working jointly to develop state of the art approaches in molecular analysis of renal disease. We will continue to perform high-quality, high-throughput single cell RNA sequencing on research biopsies from the Kidney Precision Medicine Project and advance the technology for deeper sequence coverage, reduce cost, use smaller biopsy portions without data loss so that additional technologies can be employed across KPMP, in a robust and reproducible manner. These single cell profiles will be linked to the disease states of the patients. Key signatures associated with specific cells and diseases will be extracted and localized in the spatial context of the kidney using specific, highly multiplexed RNA staining techniques. Additionally, we will employ cutting edge spatial transcriptomic technology to map cell clusters to their local environment for an added dimension of disease understanding. To this end the PREMIERE investigators will work closely with the tissue procurement sites and the Central Hub of the KPMP, using their 20 years of experience in team science, so that at the end of the KPMP funding cycle, novel cell type specific treatment targets are identified fueling the therapeutic pipelines of the future.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2027 ( Subtotal = $0 )
2027	2026	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	10/20/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2026 ( Subtotal = $627,449 )
2026	2026	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	7/29/2026	NON-COMPETING CONTINUATION	$627,449
														Subtotal = $627,449

Issue Date FY: 2025 ( Subtotal = $627,448 )
2025	2025	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	7/18/2025	NON-COMPETING CONTINUATION	$627,448
														Subtotal = $627,448

Issue Date FY: 2024 ( Subtotal = $627,448 )
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	8/20/2024	NON-COMPETING CONTINUATION	$627,448
														Subtotal = $627,448

Issue Date FY: 2023 ( Subtotal = $679,655 )
2023	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	7	7/20/2023	NON-COMPETING CONTINUATION	$627,448
2023	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	12/13/2022	COMPETING CONTINUATION	$0
2023	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	6	11/22/2022	COMPETING CONTINUATION	$52,207
														Subtotal = $679,655

Issue Date FY: 2022 ( Subtotal = $655,448 )
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	6	9/12/2022	COMPETING CONTINUATION	$655,448
														Subtotal = $655,448

Grand Total All Awards = $3,217,448

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PREcision Medicine through IntErrogation of Rna in the kidnEy (PREMIERE)

Award Number: U01DK114907

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2017

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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