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Type 1 Diabetes TrialNet Clinical Network Hub

Award Number: U01DK103282
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/09/2014
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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Type 1 Diabetes TrialNet Clinical Network Hub - Type 1 Diabetes (T1D) affects 2.5 million children and adults in the US requiring life-long insulin therapy for survival, and carries enormous clinical, financial, and psychological burdens as well as a more than 10-year reduction in life expectancy. Thus, there is a significant unmet need for new therapies that focus on underlying immune mediated beta cell destruction rather than the current symptom focused treatment. TrialNet’s mission is to address this unmet need by conducting clinical trials aimed at “altering the T1D disease course by preserving beta cell function before or after diagnosis”. As the world’s leading clinical trial group in prediction and prevention of T1D, TrialNet has made significant contributions to the field in describing the natural history of disease before and after diagnosis, testing multiple therapies to alter the disease process, and increasing understanding of disease mechanisms and response to therapy. For the past decade, the TrialNet HUB has been integral to all aspects of TrialNet activities, thus having a major impact on these accomplishments. The following specific aims address the HUB’s mission to “increase the efficiency of critical network activities through collaborative and innovative approaches for screening, recruitment, retention, trial implementation, and dissemination of results”. In Specific Aim 1, the HUB will develop and disseminate content to describe, educate, and promote TrialNet’s mission of screening individuals at risk and enrolling in clinical trials. In addition, the HUB will develop new branding and messaging to address the recent shift to screening and treatment in the context of clinical care, and also expand opportunities for all to join in TrialNet research studies. In Specific Aim 2, the HUB will support TrialNet’s clinical trial and ancillary study operations by developing participant-facing recruitment and retention materials, developing and disseminating study-specific content for clinical teams and the public, managing participant communication and developing media strategies for reporting results. The HUB will also manage participant communication and media strategies. In addition, the HUB will integrate a new comparative effectiveness study with ongoing protocols, develop and implement a mobile app for participants, increase options for home study visits, and expand opportunities to incorporate direct data entry. In Specific Aim 3, the HUB in partnership with the TrialNet Coordinating Center will coordinate network activities including developing an Ambassador program, supporting the Emerging Leaders program, working with the Community Advisory Board, establishing an External Advisory Board to address changes in the landscape, networking with leaders of general population screening programs, and expanding education about T1D prediction and therapy to those providing clinical care.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,000,000 )
2025	2025	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	9/8/2025	COMPETING CONTINUATION	$1,000,000
														Subtotal = $1,000,000

Issue Date FY: 2024 ( Subtotal = $959,999 )
2024	2024	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	10	7/18/2024	NON-COMPETING CONTINUATION	$959,999
2024	2023	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	9	7/17/2024	NON-COMPETING CONTINUATION	-$164,729
2024	2023	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	6/14/2024	NON-COMPETING CONTINUATION	$164,729
														Subtotal = $959,999

Issue Date FY: 2023 ( Subtotal = $1,000,000 )
2023	2023	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	9	6/30/2023	NON-COMPETING CONTINUATION	$1,000,000
2023	2022	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	6/21/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,000,000

Issue Date FY: 2022 ( Subtotal = $1,000,000 )
2022	2022	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	9/7/2022	NON-COMPETING CONTINUATION	$1,000,000
														Subtotal = $1,000,000

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	7	7/23/2021	NON-COMPETING CONTINUATION	$0
2021	2020	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	005	7	8/30/2021	NON-COMPETING CONTINUATION	$0
2021	2019	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	6	6/8/2021	COMPETING CONTINUATION	$1,234,858
2021	2019	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	6/3/2021	COMPETING CONTINUATION	-$1,165,674
2021	2018	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	6/3/2021	NON-COMPETING CONTINUATION	$1,165,674
2021	2018	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	5	6/8/2021	NON-COMPETING CONTINUATION	-$1,234,858
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $1,000,000 )
2020	2020	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	7	7/1/2020	NON-COMPETING CONTINUATION	$1,000,000
2020	2019	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	2/24/2020	COMPETING CONTINUATION	$1,165,674
2020	2018	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	2/24/2020	NON-COMPETING CONTINUATION	-$1,165,674
														Subtotal = $1,000,000

Issue Date FY: 2019 ( Subtotal = $1,000,000 )
2019	2019	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	9/16/2019	COMPETING CONTINUATION	$1,000,000
2019	2018	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	5	9/19/2019	NON-COMPETING CONTINUATION	$0
2019	2018	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	9/11/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,000,000

Issue Date FY: 2018 ( Subtotal = $1,699,459 )
2018	2018	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	5/18/2018	NON-COMPETING CONTINUATION	$1,699,459
														Subtotal = $1,699,459

Issue Date FY: 2017 ( Subtotal = $1,249,031 )
2017	2017	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	5/4/2017	NON-COMPETING CONTINUATION	$1,124,611
2017	2017	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 9TH AVE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	6/21/2017	NON-COMPETING CONTINUATION	$124,420
														Subtotal = $1,249,031

Issue Date FY: 2016 ( Subtotal = $1,394,997 )
2016	2016	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 NINTH AVENUE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	5/5/2016	NON-COMPETING CONTINUATION	$1,247,569
2016	2016	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 NINTH AVENUE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	7/6/2016	NON-COMPETING CONTINUATION	$147,428
														Subtotal = $1,394,997

Issue Date FY: 2015 ( Subtotal = $1,425,305 )
2015	2015	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 NINTH AVENUE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	5/15/2015	NON-COMPETING CONTINUATION	$1,425,305
														Subtotal = $1,425,305

Issue Date FY: 2014 ( Subtotal = $1,425,304 )
2014	2014	BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON	1201 NINTH AVENUE	SEATTLE	WA	98101	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	7/31/2014	NEW	$1,425,304
														Subtotal = $1,425,304

Grand Total All Awards = $13,154,095

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Type 1 Diabetes TrialNet Clinical Network Hub

Award Number: U01DK103282

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/09/2014

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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